Ask about this productRelated genes to: PPP2R2C antibody
- Gene:
- PPP2R2C NIH gene
- Name:
- protein phosphatase 2 regulatory subunit Bgamma
- Previous symbol:
- -
- Synonyms:
- PR52, IMYPNO, MGC33570, PR55G, B55gamma
- Chromosome:
- 4p16.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-01-25
- Date modifiied:
- 2017-04-05
Related products to: PPP2R2C antibody
Related articles to: PPP2R2C antibody
- Telomeres and pericentromeres are regions of heterochromatin that are difficult to replicate. Telomeric binding factor 2 (TRF2) is a key telomere protective protein that acts against DNA damage at telomeres and allows the progression of replication forks through telomere chromatin, a region with heterochromatin features that is difficult to replicate. TRF2 is also required at pericentromeres for proper replication elongation. Here, we show that TRF2 positively regulates the activity of protein phosphatase 2A (PP2A) by activating the expression of PPP2R2C, a gene encoding an isoform of the regulatory subunit of PP2A with particularly elevated expression in neuronal tissues. Mechanistically, we provide evidence that TRF2 binds to an intronic interstitial telomeric sequence (ITS) of PPP2R2C with transactivation activity. Moreover, PPP2R2C is recruited to telomeres and pericentromeres during S phase and during replicative stress where it attenuates the DNA damage response. Finally, we show that the TRF2-dependent regulation of PPP2R2C expression plays an important role in maintaining neurodevelopment in zebrafish. These results reveal a mechanism required for normal neurodevelopment by which TRF2 attenuates DNA damage by upregulating PPP2R2C, thereby stimulating PP2A activity at two regions difficult to replicate: telomeres and pericentromeres. - Source: PubMed
Publication date: 2026/01/29
Zhai XiuyunWang CuicuiYing YilinLeong WaiianChen LianxiangWei BohuaCheng XiaojiaoHuang ShengChen QiaowenLu YimingGilson EricYe Jing - Protein phosphorylation plays a crucial role in regulating the cytoskeletal and membrane proteins at the axon initial segment (AIS). However, our knowledge of AIS-specific kinases and phosphatases is very limited. Here, we report the identification of a protein phosphatase 2A (PP2A) B55 regulatory subunit enriched at the AIS in mice: Ppp2r2c. Our results demonstrate that PP2A-B55 subunits exhibit substantial heterogeneity in their subcellular localization and function. Notably, the Ppp2r2c subunit is selectively concentrated at the AIS, and this enrichment is driven by its unique structure. Utilizing a microelectrode array system (MEA), we show that Ppp2r2c modulates neuronal activity during in vitro development. With phosphoproteomics, we further reveal that the potassium channel Kv1.2 is one of the downstream targets that link Ppp2r2c activity to neuronal excitability. Together, these data provide a critical entry point for understanding the mechanisms of PP2A-mediated local phospho-regulation at the AIS. - Source: PubMed
Publication date: 2025/12/03
Anderson Andrew PKim SanghyunMelton Allison JDing XiaoyunZhang WeiSaltzman Alexander BMalovannaya AnnaRasband Matthew NGao Yudong - Beef flavor is affected by muscle metabolites and their related regulatory genes, and the molecular regulatory mechanisms vary among different beef breeds. To provide some new ways to improve meat quality and cattle breed improvement, 24-month-old ( = 8) and yellow cattle ( = 8) were selected for comparison in this study. The result revealed that the longissimus dorsi muscle fiber diameter, protein content and a-value of were significantly higher than that of yellow cattle, but the fat content was lower than that of yellow cattle. Furthermore, meat contained notably higher levels of polyunsaturated fatty acids (PUFA) and n-3PUFA than that of yellow cattle, and also had better levels of flavor amino acids (FAAs) and sweet amino acids (SAAs), which contribute to the flavor of beef. Through comprehensive analysis of transcriptomics and metabolomics, we detected a total of 109 markedly different metabolites (DEMs) and 1,677 differentially expressed genes (DEGs) in the pectoral muscles of the two breeds. Further analysis indicated that amino acid and lipid metabolism might be the key factors contributing to the differences in meat quality and flavor between and yellow cattle, involving metabolites such as L-2-aminobutyric acid, L-glutamic acid, L-glutamine, L-serine, betaine, pantothenic acid, and taurine. Through correlation analysis, we identified genes highly associated with flavor amino acids (, ), muscle development (, , ), and lipid metabolism (, , , , , 3, , , ) related essential regulatory genes and constructed a gene-metabolite interaction network for meat quality and flavor formation in . In summary, it was shown that significant differences in muscle metabolites between and yellow cattle, especially in amino acid and lipid metabolism, may be the major reason for the differences in quality and flavor between the two types of beef. This study provides a theoretical basis for further exploring the molecular regulatory mechanisms of the differences in beef quality and flavor between and yellow cattle, and provides a reference for the development and genetic breeding of high-quality cattle breeds. - Source: PubMed
Publication date: 2025/05/14
Han LinFu RunqiFu BinlongLi QianYu YeGao HuanZhang JiaweiQi MinJin ChunjiaMao ShengyongLeng Jing - Acute myeloid leukemia (AML) is a prevalent hematologic malignancy characterized by a steady rise in morbidity and mortality rates over time. The upregulation of methyltransferase-like 14 (METTL14) expression in AML has been identified; however, its specific contributions to AML progression and underlying molecular mechanisms have yet to be elucidated. - Source: PubMed
Publication date: 2024/07/20
Zhang MengmengXie ZhibinTan YuanyuanWu YanpingWang MengZhang PingpingYuan YuanLi Jiajia - Understanding the genetic basis for the molecular classification of sinonasal undifferentiated carcinoma (SNUC) based on SMARCB1 may improve our understating regarding the nature of the disease. The objective of the study was to compare the genetic profile of SMARCB1-retained (SR-SNUC) and SMARCB1-deficient SNUC (SD-SNUC). Formalin-fixed, paraffin-embedded tissue from treatment-naive patients with SNUC were selected. Three cases of SR-SNUC, four cases of SD-SNUC, and four samples of nontumor tissue (control samples) were selected. Ribonucleic acid (RNA) sequencing was performed. SR-SNUC had a higher number of variants (1 variant for every 15,000 bases) compared with SD-SNUC (1 variant every 29,000 bases). The ratio of missense to silent mutation ratio was higher for SR-SNUC (0.8) as compared with SD-SNUC (0.7). Approximately 1,500 genes were differentially expressed between SR-SNUC and SD-SNUC. The genes that had a higher expression in SR-SNUC included TPD52L1, B3GNT3, GFY, TJP3, ELL3, CYP4F3, ALDH3B2, CKMT1B, VIPR1, SLC7A5, PPP2R2C, UPK3B, MUC1, ELF5, STY7, and H2AC14. The gene that had a higher expression in SD-SNUC was ZFHX4. Most of these genes were related to either protein translation or immune regulation. The most common ( = 3, 75%) mechanisms of loss of SMARCB1 gene in SD-SNUC was loss of heterozygosity. RNA sequencing is a viable and informative approach for genomic profiling of archival SNUC samples. Both SR-SNUC and SD-SNUC were noted to have distinct genetic profiles underlying the molecular classification of these diseases. - Source: PubMed
Publication date: 2023/06/12
Chitguppi ChandalaRosen MarcNyquist GurstonToskala ElinaEvans JamesGargano StaceyTuluc MadalinaErtel AdamDsouza GlenAddya SankarJohnson JenniferBar-Ad VoichitaRabinowitz Mindy