Ask about this productRelated genes to: PPIB antibody
- Gene:
- PPIB NIH gene
- Name:
- peptidylprolyl isomerase B
- Previous symbol:
- -
- Synonyms:
- CYPB, OI9, PPIase, B, CYP-S1, SCYLP
- Chromosome:
- 15q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 1991-11-25
- Date modifiied:
- 2019-04-23
Related products to: PPIB antibody
Related articles to: PPIB antibody
- is the predominant cause of sporotrichosis in China, highlighting the need for effective vaccine strategies. Cyclophilins from pathogenic microorganisms have emerged as potential vaccine antigens. We previously generated a high-yield, high-purity recombinant truncated cyclophilin B protein (trCypB) retaining its functional domain. Here, BALB/c mice were immunized subcutaneously with trCypB alone or formulated with Freund's adjuvant to evaluate immunogenicity. Only the adjuvant-formulated vaccine induced a high antibody titer (1:51,200). Then, the infection-challenge experiments compared the trCypB formulated with Freund's adjuvant and PBS formulated with Freund's adjuvant groups. Following challenge, trCypB plus adjuvant reduced cutaneous lesion size (0.6 vs. 1.0 cm at week 1) without significantly affecting ulcer incidence. In systemic infection, vaccination increased survival to 90% versus 40% in controls and reduced organ fungal burdens. Partial cross-protection was observed against , with 60% versus 20% survival and lower fungal burdens in the kidneys and lungs. Protection against was minimal. These findings identify trCypB as a promising protective antigen against and and support further evaluation with clinically applicable adjuvants. - Source: PubMed
Publication date: 2026/09/21
Hu LingDeng BaichengHong YuyanZhong MeizhenZhi XiaoyuHu XuchuHuang Huaiqiu - While peptidyl-prolyl cis-trans isomerase B (PPIB) has been implicated in tumorigenesis and RNA metabolism, its specific function in prostate cancer is poorly understood. - Source: PubMed
Publication date: 2026/09/08
Ma ShuangyuAiliyaer AikeshanjiangChen HuixiangMao YishenRexaiti MulatiZebibula Abdureheman - - Source: PubMed
Publication date: 2026/09/09
Liu ZhaoboWang LinTang JinRan JingxuanDong LinshengLi Yadong - Gastric cancer remains a major global health burden, and robust biomarkers are needed to improve risk stratification. Although peptidyl-prolyl isomerase B (PPIB) has been suggested as a potential oncogenic factor, its clinical utility in gastric cancer remains unclear. This study aims to evaluate the clinicopathological and prognostic significance of mRNA expression and delineate its functional role in driving tumor progression. mRNA expression was evaluated in a retrospective cohort of 497 gastric cancer patients using RNAscope hybridization and digital image analysis. Functional roles and underlying mechanism were assessed through siRNA-mediated knockdown, plasmid-driven overexpression, and STAT3-targeted rescue experiments . High expression was significantly associated with aggressive clinicopathological features, including larger tumor size, advanced T stage, and lymph node metastasis. Patients with high expression had significantly worse progression-free survival (PFS) and overall survival (OS) compared to those with low expression, particularly in advanced stage. Multivariate analysis identified high expression as an independent predictor of poor PFS and OS. Functionally, silencing suppressed gastric cancer cell proliferation, migration, and invasion, whereas its overexpression enhanced these oncogenic behaviors in both cancerous and non-tumorigenic cells. These aggressive phenotypes were effectively mitigated through STAT3 targeted functional rescue experiments. PPIB is a robust independent prognostic biomarker for gastric cancer, especially in advanced stages. Its role in driving aggressive phenotypes via STAT3 signaling underscore its potential for risk stratification and as a therapeutic target. - Source: PubMed
Publication date: 2026/08/13
Kim KyungeunCho EunhoChung Eun JooSong Kwon-HoKim Tae WooChae Seoung WanChung Joon-Yong - Peptidyl-prolyl isomerase B (PPIB) is involved in the occurrence and development of various malignant tumors, yet its clinical function and molecular mechanism in head and neck squamous cell carcinoma (HNSCC) remain unclear. This study aimed to explore the biological role and underlying molecular mechanism of PPIB in the malignant progression of HNSCC. - Source: PubMed
Publication date: 2026/08/18
Liu ZhaoboWang LinTang JinRan JingxuanDong LinshengLi Yadong