CD44
- Known as:
- CD44
- Catalog number:
- 11-221-C025
- Product Quantity:
- 0.025 mg
- Category:
- -
- Supplier:
- Exbio
- Gene target:
- CD44
Related genes to: CD44
- Gene:
- CD44 NIH gene
- Name:
- CD44 molecule (Indian blood group)
- Previous symbol:
- MIC4, MDU2, MDU3
- Synonyms:
- IN, MC56, Pgp1, CD44R, HCELL, CSPG8
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
Related products to: CD44
Related articles to: CD44
- Bladder cancer (BC) exhibits high inter- and intra-patient heterogeneity, limiting the efficacy of standard treatments and underscoring the need for personalized therapeutic models. We established patient-derived organoids (PDOs) from 31 clinical BC specimens, achieving an 80.65% success rate. These organoids preserved distinct morphological subtypes: solid, hollow, and mixed and retained stable proliferative capacity. Histological and molecular analyses confirmed that PDOs recapitulated key features of the parental tumors, including a hybrid basal-luminal phenotype with elevated CD44, GATA3, and LGR5 expression, and peripheral localization of CK20 and Uroplakin 3 A (UPK3A), indicating structural polarity and urothelial differentiation. Functional drug screening of early-passage PDOs revealed heterogeneous responses to standard-of-care (SOC) agents, cisplatin and gemcitabine, as well as the EGFR/HER2 inhibitor lapatinib. Notably, lapatinib enhanced chemosensitivity in a dose-dependent manner, even at reduced concentrations of standard agents. The most effective combinatorial regimens significantly impaired organoid viability and architecture, suggesting a synergistic effect. Drug response variability across PDO lines correlated with patient-specific clinical features, including tumor grade and recurrence status. These results demonstrate that BC PDOs faithfully model tumor heterogeneity and offer a robust platform for individualized drug response profiling. Our findings support the utility of PDOs for preclinical drug evaluation and precision oncology, particularly in identifying effective combination therapies such as lapatinib-enhanced chemotherapy. - Source: PubMed
Publication date: 2026/06/27
Hekmatirad ShirinGholizadeh FatemehMontazeri SaeedSharifi LalehNowroozi Mohammad RezaHamidieh Amir AliYazdi Mohammad HoseinMollapour Sisakht Mahsa - Unexplained recurrent spontaneous abortion (URSA) accounts for approximately 50% of all recurrent spontaneous abortion cases, severely endangering the physical and mental health of women of childbearing age. Yang-Xue-An-Tai Decoction (YXAT), a traditional Chinese medicine (TCM) in-hospital preparation, has been clinically effective and safe for URSA treatment for over 30 years, but its underlying mechanism remains unclear. - Source: PubMed
Publication date: 2026/06/27
Li GuanshanHu LinlanTang JiaxinZhao XinXu ShuaiYang BinHe XianXu ZijingWang JiaboLu YawenHe Junqin - Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies worldwide, and immune evasion is a major determinant of tumor progression and therapeutic resistance. The tumor microenvironment (TME) contains multiple dysfunctional and suppressive immune states, among which regulatory T cells (Tregs) and exhausted T-cell populations are particularly important. Despite recent advances in HCC biology, the intercellular signaling programs associated with these immune states remain incompletely characterized at single-cell resolution. Therefore, this study aimed to reanalyze public single-cell RNA sequencing (scRNA-seq) data to identify candidate interaction networks and immunoregulatory signaling axes associated with T-cell dysfunction in HCC. - Source: PubMed
Publication date: 2026/06/27
Liu DingzhiYan LangChen HuiyaYuan Ling - Idiopathic pulmonary fibrosis (IPF) involves aberrant crosstalk between immune cells and mesenchymal compartments. While secreted phosphoproteins are crucial in this process, the upstream kinases regulating their post-translational modifications and biological functions remain poorly understood. Integrating single-cell RNA sequencing and macromolecular interaction analysis, we identified a pro-fibrotic FPR3 macrophage subset. We utilized co-immunoprecipitation and mass spectrometry to map the interaction between the Golgi kinase Fam20C and its substrate Osteopontin (also known as SPP1). To validate the functional requirement of this kinase in vivo, we employed a Fab'-functionalized macromolecular delivery system to specifically silence Fam20C in macrophages. We demonstrate that Fam20C phosphorylates SPP1, a critical modification that facilitates its secretion and subsequent binding to CD44 receptors on lung-resident mesenchymal stem cells (LR-MSCs). This ligand-receptor interaction inhibits the Hippo pathway, driving LR-MSC differentiation into myofibroblasts. Importantly, specific silencing of Fam20C using the targeted siRNA delivery strategy significantly attenuated fibrotic progression and blocked the macrophage-LR-MSC fibrogenic crosstalk in mouse models. This study reveals the Fam20C-SPP1 phosphorylation axis as a critical macromolecular switch in pulmonary fibrosis. Our findings provide mechanistic insights into immune-stromal communication and highlight Fam20C as a viable target for precision intervention. - Source: PubMed
Publication date: 2026/06/26
Hou JiweiChen YongchangChen HanwenFeng ZhijianChen GuanhuaJi Qijian - Sepsis-associated acute kidney injury (S-AKI) is a severe complication of sepsis, characterized by high morbidity and mortality, yet lacks effective treatment options in clinical practice. This study aims to investigate the role of SIRT2 in mediating renal injury and inflammation in S-AKI. - Source: PubMed
Publication date: 2026/06/26
Jiang YaqiongLi DanChen LiZhan ZishunHuang ZhijunYi Bin