Ask about this productRelated genes to: POMP antibody
- Gene:
- NT5C3A NIH gene
- Name:
- 5'-nucleotidase, cytosolic IIIA
- Previous symbol:
- NT5C3
- Synonyms:
- UMPH1, PSN1, PN-I, UMPH, P5'N-1, cN-III, p36, POMP, hUMP1
- Chromosome:
- 7p14.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-04-18
- Date modifiied:
- 2014-11-19
- Gene:
- POMP NIH gene
- Name:
- proteasome maturation protein
- Previous symbol:
- C13orf12
- Synonyms:
- HSPC014, UMP1
- Chromosome:
- 13q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-29
- Date modifiied:
- 2016-10-05
Related products to: POMP antibody
Related articles to: POMP antibody
- The proteasome is the major cellular proteolytic machinery. It is involved in the regulation of various pathways via the selective degradation of either short-lived normal proteins or damaged proteins permitting the cellular detoxification. Proteasome has impaired function during several biological processes, including aging and diseases; however, it can be activated through overexpression of beta(5)- or beta(1)-subunits, resulting to enhanced survival and extended lifespan. In the current study, we have investigated proteasomal up-regulation via overexpression of hUMP1/POMP protein, the known accessory factor for proteasome assembly in humans. hUMP1/POMP overexpressing fibroblasts have increased levels of functional proteasome and enhanced capacity to cope better and faster with various oxidative stressors. These data highlight hUMP1/POMP role in proteasome assembly and further strengthen the prospect of genetic manipulation of the proteasomal system. - Source: PubMed
Publication date: 2007/02/04
Chondrogianni NikiGonos Efstathios S