Ask about this productRelated genes to: PLK3 antibody
- Gene:
- PLK3 NIH gene
- Name:
- polo like kinase 3
- Previous symbol:
- CNK
- Synonyms:
- FNK, PRK
- Chromosome:
- 1p34.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-06-12
- Date modifiied:
- 2016-01-22
Related products to: PLK3 antibody
Related articles to: PLK3 antibody
- Polo-like kinases (PLKs) are a family of closely related serine/threonine kinases responsible for regulating cell cycle processes and proliferation. While PLK1 inhibitors have led to clinical candidates for oncology, the biological function of other PLKs is relatively unknown, in part, because there is a dearth of selective tool compounds. Herein we report the parallel medicinal chemistry (PMC) and structure-assisted discovery of potent and selective PLK3 inhibitors with favorable drug-like properties. We employed computational tools to reveal subtly different pharmacophore features within homologous binding sites of PLKs. These preferences were then exploited via a PMC approach starting from in-house high-throughput screening hits, resulting in selective chemical probes that help elucidate the complexities of PLK biology. Further, by profiling compounds with a spectrum of PLK selectivities, our work demonstrates the relationship between inhibition of specific PLK isoforms and resulting toxicities. - Source: PubMed
Publication date: 2026/05/13
Yap Jeremy LLovett GabrielleMason Jeremy WTucker JosephBoe DavidChen AndyCoffman Karen JDaSilva JamieDickinson TheresaFrattini VeroniqueGuan YanfeiGuiraldelli Michel FarchiHou Xinjun JJasti JayasankarKenton Nathaniel TMachin-Rivera RogerMarroquin LisaMcClendon Christopher LMcLaughlin MikaylaPecora AmandaRobinson Matthew CStock Ingrid ATria George STuttle JamisonYoung Jennifer AZhang LeiLee Alpha A - Invasive mechanical ventilation (IMV) is a critical intervention for severe respiratory failure and has been widely used in the clinical management of COVID-19 patients. The relationship between such microbiota changes and the host transcriptome in IMV patients remains poorly documented. - Source: PubMed
Publication date: 2026/06/08
Li YuxiaHuang MingzhuMao ZheyingLiu ChangQu WenxinNi JiliXu WangLi AijingBao JiaqiHan DongshengYu FeiShen YifeiWang YuefengChen WeizhenZheng Shufa - Vitamin D is one of the most popular supplements worldwide, yet its appropriate dosage and full impact on health of humans and animals are still debatable. In this study, 30 pigs were divided into three groups, differing in the amount of vitamin D in the diet (Group A - no supplementation, group B-5000 IU/Kg of vitamin D, and group C 10000 IU/Kg). After 3 months of fattening, animals were slaughtered, and samples of jejunum (the longest part of the small intestine in pigs) and colon were collected for transcriptome analysis. Comparison of the transcriptomes between jejunum and colon identified 3872 Differentially Expressed Genes (DEGs). In contrast, transcriptomic changes under the influence of vitamin D were subtle in both parts of the intestine. RNA-seq results showed that vitamin D supplementation with 5000 IU/Kg enhanced the expression of 7 genes in the jejunum and one gene (MEP1B) in the colon (FDR < 0.05, base mean > 10, and log2fold change>0.6), while supplementation with 10,000 IU/Kg increased the expression of one gene (OASL) in the jejunum. No DEGs with FDR < 0.05 were identified after supplementation with 10,000 IU/kg of vitamin D in the colon, however qPCR analysis showed that genes connected to cell cycle control (PLK1, PLK3, KIF4A, KIFC1, AURKB) are upregulated in this group. Gene Set enrichment analysis of the whole RNA-seq dataset revealed that among the most affected by vitamin D processes are that connected to immunity, especially antiviral response in the jejunum, and that connected to cell cycle control in the colon. Despite the use of very high dietary vitamin D doses, no evidence of overt intestinal toxicity was observed at the transcriptomic level. Nevertheless, the activation of molecular pathways involved in calcium handling and cell cycle regulation suggests that prolonged exposure to supraphysiological vitamin D levels may trigger adaptive responses whose long-term consequences remain unknown. - Source: PubMed
Publication date: 2026/04/19
Oczkowicz MariaWierzbicka AlicjaŚwiątkiewicz MałgorzataSzmatoła TomaszSteg AnnaSmołucha Grzegorz - Polo-like Kinase 1 (PLK1) plays essential roles in the S, G2, and M phases of the cell cycle, and its overexpression is frequently observed in multiple cancers, including breast cancer, where it contributes to genomic instability and dysregulated apoptosis. Unlike conventional ATP-competitive inhibitors that target the kinase domain, selective inhibition of PLK1's polo-box domain (PBD) offers a promising strategy to disrupt protein-ligand interactions critical for mitotic progression, thereby triggering apoptosis in cancer cells. However, the high structural similarity between PLK1 and its homologs (PLK2 and PLK3), which are vital for neurological function and the stress response, respectively, necessitates exceptional selectivity to avoid off-target effects. To address this challenge, the protocol entails a bilingual (American Sign Language and English) computational workflow that integrates virtual screening, structural clustering, protein-ligand docking, binding affinity prediction, ADMET-S profiling, and quantum mechanical (QM) stability analysis. Starting from the SuperNatural 3.0 natural product database, compounds were filtered using breast cancer relevance and drug-likeness criteria, clustered to ensure chemical diversity, and evaluated their interactions with PLK1-, PLK2-, and PLK3-PBD structures. While virtual docking and in silico ADMET-S assessments cannot definitively confirm selectivity or mechanism of action, this study generates testable hypotheses and prioritizes a focused set of natural-product-derived candidates for future molecular dynamics simulations, biochemical validation, or experimental screening. - Source: PubMed
Publication date: 2026/04/03
Mbogo Blessed PFernsebner Samantha RLawal Monsurat MLundberg Daniel JKucukkal Tugba G - Older maternal age at first vaginal delivery, defined in some studies as ≥30 years old, confers a substantial increased risk of pelvic organ prolapse. Age-related impairment of postpartum recovery of levator ani muscles may help explain this association; yet, little is known about the biomolecular changes that occur in the levator ani after vaginal delivery, or with aging. - Source: PubMed
Publication date: 2026/04/15
Swenson Carolyn WPouladi NimaZabriskie Hannah ABourrant Paul-EmileLi JianrongWilson Liam SDrummond Micah JLussier Yves A