Ask about this productRelated genes to: PLA2G4F antibody
- Gene:
- PLA2G4F NIH gene
- Name:
- phospholipase A2 group IVF
- Previous symbol:
- -
- Synonyms:
- PLA2G4F/Z
- Chromosome:
- 15q15.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-04
- Date modifiied:
- 2015-11-18
Related products to: PLA2G4F antibody
Related articles to: PLA2G4F antibody
- The widespread implementation of low-dose computed tomography (LDCT) has markedly increased the detection of pulmonary nodules, yet their genetic determinants remain poorly understood. We conducted a genome-wide association study (GWAS) of 36 175 LDCT-screened individuals from Zhejiang and Jiangsu provinces in China, assessing fourteen pulmonary nodule phenotypes defined using a convolutional neural network-based computer-aided detection (CNN-CAD) system. We identified eleven independent single-nucleotide polymorphisms (SNPs) at nine loci associated with nodule phenotypes. Functional annotation prioritized six candidate genes with either missense variants or strong colocalization evidence, including TP63 at 3q28, PLA2G4F at 15q15.1, HLA-DRB6 and CYP21A2 at 6p21.32, TNFSF11 at 13q14.11, and TNFRSF11B at 8q24.12. These genes were enriched in pathways related to cell adhesion, chemotaxis, cytokine activity, and lymphocyte activation. Several of the identified variants-associated with non-solid components, nodule size, and the number of positive nodules-were also significantly associated with increased malignancy probability of pulmonary nodules. Genetic correlation analysis revealed a substantial shared genetic basis between purely ground-glass nodules (pGGNs) and lung adenocarcinoma (LUAD) (rg = 0.79; 95% CI, 0.16-1.42; P = 0.014), and Mendelian randomization (MR) further supported a potential causal relationship, with an odds ratio (OR) of 51.1 (95% CI: 1.13-2035.31). These findings offer novel insights into the genetic architecture of pulmonary nodules and highlight a substantial genetic overlap between pGGNs and LUAD, which may inform risk prediction and precision prevention in lung cancer screening. - Source: PubMed
Zhang JiahaoZhu ChenLi QiaoSong CiZhu MengJi ChenWu LiliZhu LingyingLu JingZhang QunWu FeiyunJin ChenMou YuanlinZhu MingxuanCai JiayingZhang CaochenFu YatingGong LinnanHang DongDai JunchengJiang YueShi LeiJin GuangfuHu ZhibinShen HongbingDu LingbinMa Hongxia - Alcoholic liver disease (ALD), a major diet-related public health concern, underscores the need for effective nutritional interventions derived from edible bioresources. Quercetagetin (QG), a potent polyphenolic flavonoid abundantly found in marigolds (Tagetes erecta L.)-a plant traditionally consumed as a health-promoting herbal tea and a recognized source of the nutraceutical lutein-holds great promise for liver protection. However, its poor aqueous solubility and low oral bioavailability severely limit its application in food and nutraceutical formulations. Herein, a QG-loaded phospholipid complex self-microemulsifying delivery system (QGPC-SMEDS) was designed and optimized utilizing pseudo-ternary phase diagrams and a D-optimal mixture design, the optimized QGPC-SMEDS formulation was comprehensively characterized. It showed 4.62-fold higher permeability in Caco-2 cells and 2.55-fold greater oral bioavailability in rats versus unformulated QG. Consequently, in vivo pharmacodynamic evaluation in mice demonstrated that QGPC-SMEDS exhibited superior protective efficacy against ALD compared to free unformulated QG. Integrated analysis of metabolomic and transcriptomic data revealed that ethanol exposure induces the expression of Gm43096 and Pla2g4f, resulting in elevated levels of D-erythro-sphingosine. This upregulation activates the necroptosis pathway, contributing to the development of acute liver injury. In contrast, both QG and QGPCS treatments downregulate the expression of Gm43096 and Pla2g4f, thereby reducing the production of D-erythro-sphingosine and suppressing necroptosis. Collectively, this study not only presents therapeutically effective nanoplatform for ALD but also provides a scientifically grounded strategy for the efficient delivery of food-derived polyphenols, contributing directly to the fields of functional food development and nutraceutical science. - Source: PubMed
Publication date: 2026/02/20
Xue QiangXiao PeifuYuan HaoyangZhao JiansongLiu BoyuanHe HaibingYin TianZhang YuGou JingxinTang Xing - Sheep's meat production and quality are influenced by genetic and physiological factors that affect muscle development, growth, and fat deposition metabolism. However, the breed-specific transcriptional landscapes driving these traits in Indian sheep breeds, especially in Nellore (meat-type) and Deccani (wool-meat type) breeds are remain unexplored. Therefore, this study aimed to investigate the differences in muscle growth and fat deposition between Nellore and Deccani breeds by integrating transcriptomic profiling, carcass characteristics, and histological analysis of longissimus dorsi muscle and liver tissues. Carcass assessment revealed higher Hot Carcass Weight (HCW), Cold Carcass Weight (CCW), Hot Carcass Yield (HCY) and Cold Carcass Yield (CCY), and larger myofibrillar cross-sectional area ( < 0.05), indicating enhanced musculature, which was observed in Nellore. Deccani showed elevated Intramuscular Fat (IMF) deposition ( < 0.05), indicating improved meat flavour/juiciness. Transcriptomic profiling revealed several Differentially Expressed Genes (DEGs) associated with meat quality and quantity traits. In Nellore, the genes WFIKKN2, FGFRL1, FKBP4, and IRF1 were upregulated, while the gene TAS1R2 was downregulated, leading to enhanced muscle development, superior carcass traits, thermotolerance, and immunity. While Deccani showed higher expression of lipid metabolism genes PLA2G4F, ACSL1, ACOX1, CPT1A, and PLIN1, which are linked to higher IMF content. Functional enrichment analysis revealed 46 significantly enriched GO terms for the DEGs ( < 0.05), including oxidoreductase activity, muscle development, etc. These outcomes demonstrate novel genetic markers and key biological insights into the regulation of muscle development, thermotolerance, immunity, and IMF for future validation in Indian sheep breeds. - Source: PubMed
Publication date: 2026/02/01
Pothireddy NavyaVishnuraj Mangalathu RajanVijaya Rachel KappalaBaswa Reddy PeddapuramNagaraja Prashantha ChowdadenahalliGanesan AjayKanneboyina Shiva ShankarIndiradevi KrishnachaithanyaBarbuddhe Sukhadeo Baliram - The spleen is essential for immunity, mediating host defense against pathogens and regulating immunological homeostasis. Western-style diets commonly cause the aggregation of body fat and the emergence of obesity. This state might lead to damage to the spleen's functions. However, the effects of Western-style diets on gene expression and metabolic regulation in the spleen have not yet been fully explored. In this study, mice were fed either a high-fat diet (HFD) or standard chow (CHFD) for 10 weeks starting at 8 weeks old. Weekly weights were recorded, and spleens were weighed at 18 weeks. The results showed that HFD mice had significantly higher body weights from 12 weeks ( < 0.05) and a higher splenic index at 18 weeks ( < 0.01). HE staining revealed disrupted spleen structures and infarcted areas in the HFD group. Transcriptome sequencing highlighted immune-related pathways, including inflammatory response and interleukin-6 production. Among the differentially expressed genes (DEGs), , , and were significantly upregulated in the HFD group, whereas and exhibited significant downregulation. emerged as a key hub gene in PPI analysis. Metabolomics analysis identified significantly different metabolites (SDMs), including Rifamycins, 7-Ketodeoxycholic Acid, Folinic Acid, and Lotaustralin, as key biomarkers for an HFD, while 1-Methylnicotinamide and Prostaglandin E1 were significant for CHFD. KEGG enrichment linked glycerophospholipid and arachidonic acid metabolism to both transcriptome and metabolome results. The joint analysis of transcriptome and metabolome data revealed that was negatively correlated with Biliverdin and 1-methylnicotinamide, and was inversely correlated with 7-Ketodeoxycholic Acid. These findings offer insights into the molecular mechanisms and metabolites that influence spleen immunity and systemic immune homeostasis. - Source: PubMed
Publication date: 2025/08/27
Tang ShengguoLi DongfangMa YannaZhao ZhiyingPeng LiangyuanLiao ShuchaoMa HaimingWei Hongjiang - Metabolic reprogramming is an emerging hallmark and promising therapeutic target in cancer, fueling malignant cells and regulating the tumor microenvironment as a metabolic checkpoint. Triple-negative breast cancer (TNBC), an aggressive subtype with poor prognosis, is marked by high recurrence rates and chemotherapy resistance. However, the metabolic heterogeneity and cell-specific metabolic profiles in TNBC remain underexplored. In this study, we analyzed the expression and prognostic impact of 87 metabolic pathways involving 1,668 genes, identifying 104 candidate metabolic checkpoint genes. Using consensus clustering, we uncovered two distinct metabolic subclusters of TNBC patients that exhibited significant differences in survival. We further characterized the differentially expressed genes, mutation profiles, and microenvironmental features between these two clusters. Additionally, -omics analysis of single-cell RNA sequencing revealed that , a gene specifically expressed in malignant cells, functioned as a cell-autonomous metabolic reprogramming factor. We validated that promotes the proliferation, migration, and survival of TNBC cells , driven by dysregulated glucose and lipid metabolism. These processes were mediated, at least in part, through the activation of the signaling pathway. This study highlights the metabolic heterogeneity in TNBC and identifies as a pro-tumor factor, suggesting it as a potential novel therapeutic target. - Source: PubMed
Publication date: 2025/03/07
Tang XunJiang NingKou YingyingCheng ShanYan Feng