Ask about this productRelated genes to: PIP4K2A antibody
- Gene:
- PIP4K2A NIH gene
- Name:
- phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
- Previous symbol:
- PIP5K2A
- Synonyms:
- PIP5KIIA, PIP5KIIalpha
- Chromosome:
- 10p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-22
- Date modifiied:
- 2016-04-11
Related products to: PIP4K2A antibody
Related articles to: PIP4K2A antibody
- The PIP4K family of lipid kinases phosphorylates the rare phospholipid PI(5)P at the 4-position, generating PI(4,5)P inside the cell. Although the functions of PIP4K, as well as the intracellular pools of PI(5)P and PI(4,5)P, remain incompletely understood, there are emerging interests in developing inhibitors to target these kinases since their genetic ablations have broad tumor-suppressive and other beneficial effects. Here, we report continued optimization of a previously discovered 2-amino-dihydropteridinone PIP4K2A/2B inhibitor and demonstrate, for the first time that pharmacological inhibition of PIP4K2A/2B suppresses solid tumor growth . The tumor-suppressive effect of the inhibitor appears to be non-tumor cell-autonomous and is likely mediated by components of the tumor microenvironment, including macrophages that commonly adopt alternatively activated states and support tumor growth. Our findings suggest a potential role for PIP4K activity in tumor-associated macrophages and provide a rationale for further exploring pharmacological targeting of these lipid kinases in cancer. - Source: PubMed
Publication date: 2026/04/30
He ZunyuChen SongBosenberg MarcusMuthusamy ViswanathanXi YiboWang HeMicheli FabrizioCianciulli AgostinoBeato ClaudiaVan Zandt MichaelEllman JonathanHa Ya - The phosphatidylinositol 5-phosphate 4-kinases (PIP4Ks) are an evolutionarily conserved family of lipid kinases that phosphorylate phosphatidylinositol 5-phosphate to generate phosphatidylinositol 4,5-bisphosphate. In mammals, the catalytically active α and β isoforms, encoded by PIP4K2A and PIP4K2B, respectively, localize to distinct cellular compartments and have been implicated in metabolism, immune regulation and tumorigenesis, prompting interest in their pharmacological inhibition. Notably, most reported small-molecule inhibitors display substantially higher potency towards the α isoform than the β isoform, suggesting intrinsic structural features that limit the effective targeting of PIP4K2B. Here, we report the crystal structure of PIP4K2A in complex with 422A, a potent dual α/β inhibitor with improved metabolic stability. The structure reveals an unexpected, water-mediated interaction in which a pyridyl nitrogen of the inhibitor engages a conserved structured water molecule in the roof of the specificity pocket, constraining the orientation of the pyridylmethyl side chain and stabilizing a rigid, high-affinity binding mode. Comparative structural analysis with the PIP4K2A-selective inhibitor BAY-091 shows that deeper penetration into the specificity pocket enhances PIP4K2A binding but is accompanied by local steric constraints that are likely to be less well tolerated in PIP4K2B. Together, these findings define structural determinants of isoform-dependent inhibitor binding within the PIP4K family and provide a framework for structure-guided optimization of lipid kinase inhibitors with improved isoform balance. - Source: PubMed
Publication date: 2026/05/12
He ZunyuChen SongMicheli FabrizioCianciulli AgostinoBeato ClaudiaEllman JonathanHa Ya - Alzheimer's Disease (AD) is among the most prevalent neurodegenerative disorders globally, yet effective early diagnostic strategies remain lacking. Advances in multi-omics technologies and the integration of artificial intelligence into medicine have created new opportunities for developing predictive models for AD. Biomarker-based models hold significant promise for enhancing early detection. In this study, we integrated multi-omics data to identify core risk genes with potential causal links to AD and developed an early diagnostic model, thereby providing a theoretical framework for precision intervention. - Source: PubMed
Publication date: 2026/03/24
Zhang YazhiLi ZiweiLi HanruiZhang Kuixing - Kongshan cattle is an indigenous breed from Sichuan Province, China, characterized by their excellent meat quality, high fertility, strong disease resistance, and remarkable environmental adaptability. However, their genomic diversity has not been systematically studied. In this work, we performed whole-genome sequencing of 30 Kongshan cattle from a breeding farm and integrated these data with 113 representative commercial and indigenous cattle breeds worldwide to investigate their population structure and genetic diversity. We further analyzed the ancestral contributions to the development of the breed. The population structure revealed that Kongshan cattle possess four types of ancestral components: East Asian indicine (0.5974), East Asian taurine (0.3464), European taurine (0.0483), and Indian indicine (0.0079). The population also exhibits high nucleotide diversity, second only to pure East Asian indicine cattle. We inferred the ancestry of each variable site in the genome and, in combination with integrated haplotype score analysis, identified candidate genes related to meat quality (, , , , and ), immunity (, , , , , , , and ), and environmental adaptability (, , , , and ). These findings provide valuable insights into the evolutionary history and ancestral origins of Kongshan cattle and contribute to the broader understanding, conservation, and sustainable utilization of indigenous Chinese cattle genetic resources. - Source: PubMed
Publication date: 2025/12/12
Bai MengmengYang KaiMa XiaohuiBian ChenqiWang WeiYi JunChen NingboLei ChuzhaoXia Xiaoting - It is of great significance to identify candidate genes and molecular markers related to the comb development, in order to accelerate comb breeding progress of yellow feathered broiler. Herein, 400 terminal male chickens of the fast-type yellow feathered broiler (60 day old on the market) were selected as the research subjects, and their genomic genetic variation information was obtained using resequencing and genome-wide association study (GWAS). We identified 4 SNPs and 80 SNPs that were significantly correlated and potentially significantly correlated with comb height. Meanwhile, 4 SNPs and 5 SNPs were potentially significantly correlated with comb thickness and comb length, respectively. Several candidate genes related to comb traits were identified, including AR, HSF3, PIP4K2A, ATF6β, NTM, LRP1, etc. Except for SNP6 (rs317557994) locus with low genetic diversity, the other 12 SNP loci have moderate genetic diversity. Linkage disequilibrium (LD) analysis showed that 13 SNP loci were not in a strong linkage state. The association analysis between single marker and comb traits showed that AA and GA at SNP1 (rs312669246) locus, CC and CT at SNP2 (rs313331126) locus, AA and GA at SNP3 (rs313205409) locus, and AA and GA at SNP4 (rs314830898) locus were the dominant genotypes for comb height. The TT and CT genotypes at SNP5 (rs312557738), AA at SNP6 (rs317557994), GG at SNP7 (rs738748642), and AA and GA at SNP8 (rs312962270) were the dominant genotypes for comb thickness. TT at SNP9 (rs313797960), AA at SNP10 (rs312371971), AA at SNP11 (rs313637016), CC and CA at SNP12 (rs738049404), and GG at SNP13 (rs3388194039) were all the dominant genotypes for comb length. In chicken breeding, it is expected to assist in improving the selection of comb traits and accelerating the generation progress of comb development by selecting dominant genotypes at SNP1-SNP13 loci and eliminating other disadvantaged genotypes. These findings provide important references for further studying the regulatory mechanisms of comb development and cultivating new high-quality broiler breeds (crossed lines) with larger comb. - Source: PubMed
Publication date: 2025/11/16
Tu YunjieXu ShenghaiLiu YifanZhang MingMa JunJu XiaojunShan YanjuJi GaigeShu Jingting