Ask about this productRelated genes to: PHIP antibody
- Gene:
- PHIP NIH gene
- Name:
- pleckstrin homology domain interacting protein
- Previous symbol:
- WDR11
- Synonyms:
- ndrp, FLJ20705, DCAF14, BRWD2
- Chromosome:
- 6q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-05-04
- Date modifiied:
- 2016-10-05
Related products to: PHIP antibody
Related articles to: PHIP antibody
- Polymethoxyflavones (PMFs) are investigated for their inhibitory mechanisms against heterocyclic aromatic amines (HAs) and advanced glycation end products (AGEs). Tangeretin, isosinensetin (ISN), 3',4',5,7-tetramethoxyflavone (TMHF), and their mixture dose-dependently suppressed the formation of PhIP, CML, and CEL, with ISN and the mixture showing the strongest activity. PMFs also effectively scavenged free radicals and reduced key intermediates, including phenylacetaldehyde, glyoxal (GO), and methylglyoxal (MGO). UPLC-TOF-MS analysis revealed novel GO/MGO-PMF adducts, indicating that PMFs trap α-dicarbonyl compounds via covalent binding. In silico toxicity prediction suggested these adducts have lower mutagenic potential and chronic oral toxicity than PhIP, CML, and CEL. Collectively, PMFs inhibit HAs and AGEs through a dual mechanism of radical scavenging and reactive intermediate trapping, transforming hazardous precursors into less toxic products. These findings support PMFs as effective and safe natural inhibitors for mitigating process-induced contaminants in thermally processed foods. - Source: PubMed
Publication date: 2026/04/17
Yang DiaodiaoDeng PengZhou QingfengGao FengyiLiu JianwenXiao WenjingZeng MaomaoQuan Wei - PHIP (PH Interacting Protein) is an Insulin Receptor Substrate 1 (IRS1) interactor protein that binds to acetylated IRS1 through its bromodomain. Due to its involvement in insulin signaling pathway, it is implicated in various malignancies and metabolic disorders. Despite this role, the phosphoregulatory network governing PHIP activity is understudied. Therefore, current study aimed to elucidate the landscape of PHIP phosphorylation and its functional significance in insulin signaling by employing a global phosphoproteomic data integration and harmonization strategy. - Source: PubMed
Publication date: 2026/04/29
Sujina AyadathilFahma AmalSubair SuhailGopalakrishnan Athira PerunellyUmmar SamseeraShivamurthy Prathik BasthikoppaRaju RajeshRamesh Poornima - Exposure to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) may promote the initiation and progression of prostate cancer (PCa); however, its precise molecular mechanisms remain unclear. - Source: PubMed
Publication date: 2026/04/10
Wen YaoanYang JiangbinSu YuzheChen ShaoyuanZheng SongZhu ShaoxingChen GuoqiangZhan Shuyuan - Immune reactivity to the gut mycobiome has been implicated in inflammatory bowel disease (IBD), particularly Crohn's disease (CD), but the systemic adaptive immune repertoire targeting the gut mycobiome remains incompletely defined. We aimed to map systemic T cell and antibody responses to fungal antigens in IBD. - Source: PubMed
Mahdy Aya K HElAbd HeshamPrinzensteiner MelanieJebens HannahSivickis KostasBacher PetraVogl ThomasPoyet MathildeFranke Andre - 2-Amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) is a highly polar heterocyclic amine with elevated levels in high-temperature meat products and strong carcinogenicity. This study screened Pediococcus acidilactici X3-1B, achieving a PhIP adsorption rate of 74.30%. The stability of the complex formed between the strain and PhIP was highest at 0 h, 4 °C, and pH 7. Scanning electron microscopy (SEM) revealed significant morphological changes in the strain after PhIP adsorption. Fourier transform infrared spectroscopy (FTIR) results indicated that NH and CO groups on the bacterial surface played a primary role in adsorption. Zeta potential measurements revealed an increase in net negative charge on the bacterial surface following PhIP adsorption. Functional group chemical masking indicated that amino groups are one of the core functional groups influencing X3-1B's adsorption of PhIP. This study provides theoretical foundations and practical references for the application of lactic acid bacteria in food safety. - Source: PubMed
Publication date: 2026/04/04
Wei YuzhuoGuo WenJingHao ShiqiSun XueyingSun LinaSun ErkeLi XiaotongJin YeZhao Lihua