Ask about this productRelated genes to: PGRMC1 antibody
- Gene:
- PGRMC1 NIH gene
- Name:
- progesterone receptor membrane component 1
- Previous symbol:
- -
- Synonyms:
- HPR6.6
- Chromosome:
- Xq24
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-25
- Date modifiied:
- 2016-10-05
Related products to: PGRMC1 antibody
Related articles to: PGRMC1 antibody
- Malignancy has traditionally been viewed as a genetic disease driven by mutation and clonal selection. However, growing evidence indicates that tumors also exploit conserved developmental and immunological programs that predate cancer development. Among these, placentation stands out as a prominent biological analogy. During pregnancy, trophoblast cells exhibit rapid growth, controlled invasion, angiogenesis, metabolic adaptability, and localized immune tolerance, features that closely resemble those of aggressive tumors. This review revisits the trophoblastic theory of cancer and suggests that a specific biologically defined subset of solid tumors may evolve through a placentation-like system rather than directly from a trophoblastic lineage. We examine evidence showing that progesterone, acting via nuclear progesterone receptors and membrane-associated mediators such as PGRMC1, can induce immune-regulatory effectors, including progesterone-induced blocking factors (PIBF) and HLA-G, in preclinical models. We also discuss important caveats: HLA-G and metabolic reprogramming are not unique to placentation but can also be triggered by hypoxia, inflammatory cytokines, and epigenetic plasticity. Therefore, we do not argue for a trophoblastic origin but for the convergent activation of conserved survival strategies, which, when sustained and protected from immune attack, create a tumor-permissive environment. Finally, we propose a biomarker-driven, ethically guided clinical framework to evaluate the use of progesterone receptor antagonists or modulators in cancer treatment. The trophoblastic model, as a systems-level hypothesis, provides testable predictions that combine endocrine biology with modern immuno-oncology and may uncover previously unrecognized therapeutic vulnerabilities in cancers. - Source: PubMed
Publication date: 2026/03/26
Hoang Ba XHoang Thanh XHoang CuongHan Bo - Chinese sturgeon (Acipenser sinensis), a critically endangered fish species, faces significant challenges in artificial propagation, with sperm quality being a key limiting factor. This study investigated the relationships among sperm quality parameters, serum reproductive hormone concentrations, and the expression of membrane-bound progesterone receptors (membrane progestin receptor α (mprα) and progesterone receptor membrane component 1 and 2 (pgrmc1 and pgrmc2)) in sexually mature male Chinese sturgeon during the spawning season. Computer-assisted sperm analysis (CASA) revealed that the normospermic group exhibited significantly higher sperm motility, A-grade sperm proportion, and mean angular displacement (MAD) than the asthenospermic group. Serum hormone assays showed that the concentrations of 17α,20β-dihydroxy-4-pregnen-3-one (17α,20β-DHP), 11-keto testosterone (11-KT), and luteinizing hormone (LH) were markedly elevated in the normospermic group. Molecular identification and bioinformatics analysis confirmed the presence of mprα, pgrmc1, and pgrmc2 in Chinese sturgeon, revealing their structural characteristics and high conservation across vertebrates. Tissue distribution analysis demonstrated sex-specific expression patterns of these genes across various tissues (pituitary, gonad, liver, heart, skin, intestine, and gill) in two-year-old fish. Notably, mRNA expression levels of these genes were significantly down-regulated in the asthenospermic group. These findings suggest that impaired progesterone signaling and endocrine dysregulation may contribute to reduced sperm motility. Our results provide foundational insights into the role of membrane-bound progesterone receptors in Chinese sturgeon reproduction, offering potential biomarkers for sperm quality assessment and targets for improving artificial breeding strategies in this endangered species. - Source: PubMed
Publication date: 2026/03/18
Ding YifanWei YouchuanYu ZhaoxiYang JingWang BinzhongZhang DezhiGuo BaifuZhu XinYin ZhanHuang HongtaoXiao KanShi XuetaoJiang WeiShu Tingting - Accurate protein recognition is crucial for early disease diagnosis and biomarker screening. Progesterone receptor membrane component-1 (PGRMC1) is a promising cancer biomarker, yet its sensitive and selective detection in complex biological samples remains challenging. Here, a molecularly programmable multichannel fluorescence sensor array was constructed by employing three chemically distinct carbon dots (CDs), synthesized from Congo red coupled with ascorbic acid, citric acid, and glutathione, as parallel sensing units to generate multiple fluorescence response channels. This precursor-engineering strategy enabled the precise modulation of surface functional groups, redox properties, and protein-interaction behaviors, offering a novel route to tailor CDs for specific sensing targets. The resulting CDs functioned as complementary fluorescent sensing units, collectively forming a cross-reactive array capable of 100% accurate discrimination of 11 proteins in both buffer and whole blood samples. For the clinically relevant biomarker PGRMC1, the array displayed a broad linear response (0.010-1.000 ng/mL) and an ultralow limit of detection of 0.013 ng/mL (95% confidence interval from 0.004 to 0.021 ng/mL). More importantly, the analysis of 64 blinded clinical blood samples achieved robust differentiation between breast cancer patients and healthy individuals, demonstrating its translational potential for early cancer diagnosis. Fluorescence lifetime analysis combined with density functional theory calculations elucidated the underlying mechanism of interaction between the CDs and proteins, highlighting the contribution of precursor-dependent surface states. This study introduces a new design paradigm for CD-based fluorescent arrays and showcases their strong promise for complex biological analysis, precision biomarker detection, and clinical diagnostics. - Source: PubMed
Publication date: 2026/03/04
Guan YuweiZhang MengyingRuan XiangyanWang YuejiaoGu MuqingWei Yun - The risk of developing some types of head and neck squamous cell carcinoma (HNSCC) is seven times higher in males, and such disparities may not be associated only with tobacco and alcohol consumption or HPV infection. Therefore, the endocrine microenvironment is considered another risk factor, as epidemiologic studies have unequivocally shown the protective effect of estrogen in women. This research was focused on progesterone receptors (PRs), the least-studied sex hormone receptors in HNSCC. Our study included fresh tissue samples from 95 primary tumors, 25 metastatic lymph nodes and 40 healthy oral mucosa. Gene expression of nuclear () and seven membrane PRs (, , , , , and ) was analyzed by qRT-PCR and associated with clinicopathological characteristics. The results showed that, compared to control tissue, was increased in metastatic lymph nodes, while , , and were decreased in primary tumors (all < 0.05). The expression of almost all PRs was greater in older patients and showed moderate to strong positive mutual correlations in both tumors and controls. and were increased in females and pT4 tumors (all < 0.05). Survival analysis showed that higher (hazard ratio (HR) 2.8, 95% confidence interval (CI) 1.19-6.57, = 0.019) and (HR 2.0, 95% CI 1.01-3.81, = 0.048) were associated with worse overall survival, but their independence was not proven in multivariate analysis. Although most PRs were reduced in primary tumors, an increased expression, also associated with tumor invasion markers, could likely mark a specific aggressive, advanced stage of primary tumors and potentially serve as a negative prognostic biomarker for HNSCC. - Source: PubMed
Publication date: 2026/02/14
Jelačić JosipaMilutin NinaStojković IlijanaVugrinec OzrenKvolik Pavić AnaVušković SanjaMumlek IvanZubčić VedranLeović DinkoBilić MarioOzretić Petar - Breast cancer (BC) is the most common neoplasm in women, and its growth mainly depends on estrogen, but the mechanism of estrogen in BC is still not fully understood. Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary conservation and stability. This study aimed to investigate the roles and mechanisms of circRNAs in ER-positive BC. - Source: PubMed
Publication date: 2026/01/31
Yang JingwenLi YamingWang ZekunSun YuhanHe YinqiaoNiu TongLiang YiranChen XiChen TongHan DianwenZhang NingZhao WenjingChen BingWang LijuanLuo DanLi XiaoyanYang Qifeng