Ask about this productRelated genes to: PGM2 antibody
- Gene:
- PGM2 NIH gene
- Name:
- phosphoglucomutase 2
- Previous symbol:
- -
- Synonyms:
- FLJ10983
- Chromosome:
- 4p14
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2014-11-19
Related products to: PGM2 antibody
Related articles to: PGM2 antibody
- Prostatic hyperplasia is a common condition among aging males characterized by excessive prostate cell proliferation, and while it is a benign process, it involves significant metabolic reprogramming and immune infiltration-features typically associated with malignant tumors. This study aimed to elucidate the interaction network between the PIEZO channels and genes related to glycometabolic reprogramming and mitochondrial oxidative phosphorylation (OXPHOS), highlighting their roles in the progression of prostatic hyperplasia. - Source: PubMed
Publication date: 2026/03/23
Zheng YajieZhao FuguangXu PengweiZeng ChuchuSun ZongrunWu GuanlinWang Yibin - Long tails trigger tail biting in pigs and increase the risk of flystrike infections in sheep. Tail docking has been a common management practice in both species for decades, but increasingly conflicts with legal animal welfare guidelines. Sustainable solutions require breeding strategies targeting shorter tails. In consequence, the aims were to conduct whole-genome sequencing (WGS)-based genome-wide association studies (GWAS) and comparative genomic analyses (CGA) to explore functional elements influencing tail traits. Phenotypically divergent experimental populations of pigs and sheep were established through unified selection and mating experiments. Tail traits included tail length (TL) measured at birth, and tail abnormalities (TA) assessed radiographically at 14 weeks of age. WGS-based GWAS identified a significant locus on SSC18 in pigs and suggestive loci for TL in both species, which, together with previously reported loci for TA, were further analyzed by CGA. The genomic windows of the significant locus on SSC18 in pigs and the TL GWAS locus on OAR4 in sheep were found to be conserved, harboring six common genes with predicted functional variants. These variants were jointly associated with TL (Plm < 0.05) in both species in linear regression models adjusted for sex, age of the dam, body length, and body weight. In other GWAS locus windows (±1 Mb), species-specific TL candidate genes were identified in sheep (HOXB13, MUC5B, EPB41L3, MTCL1, PIEZO2, MPPE1, and LOXHD1) and in pigs (KNL1, DISP2, SPRED1, TGFB2, and HAND1), each harboring associated putative functional variants. For TA, sheep-specific candidates (PGM2, LRRC66, CRACD, LOC105601916, and SH2D4B) and pig-specific candidates (MYOT, TMCO6, and PCDHAC2) were revealed using logistic regression models (Pglm < 0.05). GO analyses of candidate genes predicted shared biological processes between sheep and pigs, whereas pathway analyses indicated that common carbohydrate metabolism pathways, along with species-specific immune and inflammatory signaling, and pig-specific TGF-β signaling and endochondral ossification, may contribute to tail length variation and abnormalities. These findings provided deeper insights into the genetic basis of differential embryonic tail morphogenesis and perinatal tail development across species. - Source: PubMed
Publication date: 2026/03/03
Zhang XuyingMainzer JohannaGiambra IsabellaYin TongEngel PetraHümmelchen HannahWagner HenrikWehrend AxelEgerer ChristianeGerhards KatharinaReiner GeraldKönig Sven - In order to explore the main regulatory genes and related pathways of growth traits, transcriptome sequencing was performed on the hypothalamus, pituitary, and liver tissues of 12-month-old greater amberjack () with different growth rates. In total, 504 (118 up- and 386 down-regulated), 556 (283 up- and 273 down-regulated), and 699 (224 up- and 475 down-regulated) differentially expressed genes (DEGs) were identified in the hypothalamus, pituitary, and liver tissues, respectively. GO and KEGG pathway analyses revealed significant differences in the expression of several genes involved in growth, metabolism, and immune-related pathways. The mRNA expression levels of genes related to growth (, , ), cell proliferation (, , , , and ), and lipid metabolism (, , , , and ) were up-regulated in the fast-growing (FG) group, while the and were down-regulated. Conversely, genes associated with glycolysis (, , ), citrate cycle (, ), and immune-related pathways (, , , , , , and ) were up-regulated in the slow-growing (SG) group. These findings indicate that the FG exhibited greater lipid metabolism capacity and cell proliferation ability, while the SG expended additional energy to cope with environmental stress, with hindered growth during immune response. This study enhances our understanding of the genetic mechanisms underlying differences in growth rates and provides essential gene resources for future growth-related molecular breeding programs in greater amberjack. - Source: PubMed
Publication date: 2026/02/06
Ru XiaoyingLi XiaojingHuang YangChen PeipeiDeng QiuxiaLi HangZhou QibingLin HaoyiHao RuijuanLiao YongguanWu JinhuiZhao YanfeiZhu Chunhua - Rumen microbiota drive fermentation and contribute to variation in feed efficiency among ruminants, yet the underlying host-microbe mechanisms remain poorly understood. This study explores how rumen microbes shape feed conversion efficiency (FCR) through integrated interactions with multiple host organs. - Source: PubMed
Publication date: 2026/02/03
Jia XiaoweiZhang YuanxinTian BoyaZhang GuijieMao ShengyongQian WenxiSun DamingLiu Junhua - Hypertrophic Cardiomyopathy (HCM) is a complex cardiac disorder marked by the thickening of the heart muscle. - Source: PubMed
Publication date: 2025/03/26
Hu HuanhuanYu ZihengLu KongjieHu HuiDeng Lang