Ask about this productRelated genes to: PGM1 antibody
- Gene:
- PGM1 NIH gene
- Name:
- phosphoglucomutase 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: PGM1 antibody
Related articles to: PGM1 antibody
- The twospot puffer (Takifugu bimaculatus) is a species of significant aquacultural value in East Asia, yet its production is constrained by slow growth rates and suboptimal body morphology. To advance genetic enhancement via marker-assisted selection, we conducted a genome-wide association study (GWAS) focusing on traits related to body shape. Utilizing a full-sib family comprising 167 individuals to reduce genetic variability, we employed whole-genome resequencing to identify 122,553 high-quality (SNPs) for association analysis. Our study identified 17 significant and suggestive SNP loci correlated with torso length (TL), body depth (BD), body width (BWI), head length (HL) and tail length (TAL). Functional annotation of surrounding genomic regions revealed 26 candidate genes associated with these traits, including lrp8, kank4 for TL; tfrc, dab1 for BD; pgm1, cp, rala, and cdh7 for BWI; gli3, sox17a, and zip12 for HL; myl9, smurf2 for TAL. These genes were implicated in skeletal development, cell migration, metabolism, and BMP/TGF-β signaling pathways. Our findings offered the first genetic insights into body shape in T. bimaculatus and provided valuable SNP markers for future genetic mapping of body shape related traits in multi-line famlies and marker-assisted selection breeding programs. - Source: PubMed
Publication date: 2026/04/01
Zhao HongbinWang LingzheChang YanwenLiang ShuangLiang JianLiu HuiruSong AnranLi LeibinGuo YongjunZhou Zhixiong - Phosphoglucomutase 1 (PGM1) is a type 1 diabetes susceptibility gene that potentially plays a key role in regulating central carbon metabolism in β-cells. Previous work suggested that β-cell PGM1 transcription is lowered after coxsackievirus B4 infection. Thus, we hypothesized that decreased PGM1 levels disrupt β-cell metabolic homeostasis and result in β-cell fragility and type 1 diabetes. First, we showed that the synthetic double-stranded RNA polyinosinic:polycytidylic acid, or Poly(I:C) attenuated PGM1 transcription both in human islets and EndoC-βH1 cell line. At 5.5 mmol/L glucose, PGM1 deficiency enhanced the rate of glycolysis, tricarboxylic acid cycle, hexosamine, and pentose phosphate pathway. However, at 20 mmol/L glucose, PGM1-deficient cells showed impaired mitochondrial respiration. Moreover, truncated N-glycans were enriched in PGM1-deficient cells, suggesting aberrant protein glycosylation. Autophagic flux, which was dependent on the lysosomal glycosylated protein function, was impaired in PGM1-deficient cells. Increased endoplasmic reticulum stress was evident in PGM1-deficient cells. Our results suggest that PGM1 is a metabolic regulator of pancreatic β-cells. Its deficiency leads to metabolic imbalance and cellular stress, potentially augmenting type 1 diabetes development. - Source: PubMed
Publication date: 2026/03/31
Ye JodyQiu YunpingAguilan Jennifer TSun YanKulkarni RuchaJankauskas Stanislovas SSantulli GaetanoSidoli SimoneKurland Irwin JTomer Yaron - This study reports the interfacial engineering of poly(vinylidene fluoride) (PVDF) nanocomposites using a hybrid nanofiller comprising few-layered graphene and a copper-based metal-organic framework (Cu-MOF) to simultaneously enhance piezoelectric energy harvesting and piezocatalytic activity. The nanocomposites were prepared via melt-mixing followed by solution-casting, enabling uniform hierarchical nanofiller dispersion and strong interfacial coupling with the PVDF matrix, as observed from detailed vibrational spectroscopy and microscopic analyses. FT-IR analysis revealed a remarkably high electroactive β/γ-phase content (∼97.2%) for 1.5 wt % hybrid nanofiller concentration, arising from synergistic dipole-dipole and ion-dipole interactions at the polymer-nanofiller interfaces. The corresponding piezoelectric nanogenerator delivered an open-circuit voltage of ∼58.3 V, a peak-to-peak voltage of ∼88.9 V, and a power density of ∼52.7 μW cm. Beyond energy harvesting, the PGM-1.5 nanocomposite film exhibited efficient dark piezocatalytic reduction of toxic Cr(VI) to Cr(III) (∼50% removal) under ultrasonic excitation, driven by mechanically induced polarization rather than cavitation or adsorption. Broadband dielectric spectroscopy, ferroelectric studies, and postcatalytic film stability analyses further confirmed lower dielectric losses for PVDF hybrid nanocomposites compared to neat PVDF, rapid interfacial charge dynamics, and structural robustness. These findings establish the Cu-MOF/graphene-engineered PVDF nanocomposite as a multifunctional platform for mechanically driven energy and environmental applications. - Source: PubMed
Publication date: 2026/03/20
Mohandas NikhilLakra HemrajKamble RiddhiBanerjee SusantaBhattacharyya Arup R - Muscle fiber density at hatching is closely associated with post-hatch meat yield through subsequent hypertrophy and with meat tenderness at market age. However, inter-individual variation in muscle fiber traits among goslings remains poorly understood. In this study, 129 one-day-old Yangzhou goslings were sampled and classified into three phenotypic groups based on gastrocnemius muscle weight and muscle fiber density: high meat yield-high fiber density (HH; 0.56 ± 0.01 g, 7803.88 ± 434.12 n/mm²), high meat yield-low fiber density (HL; 0.59 ± 0.03 g, 3847.01 ± 135.68 n/mm²), and low meat yield (LY; 0.46 ± 0.02 g, characterized by lower body weight and muscle mass). A 4D label-free quantitative phosphoproteomic approach was then applied to uncover phosphorylation-mediated mechanisms regulating early muscle fiber development. In total, 6,412 phosphorylation sites corresponding to 5,548 phosphopeptides and 2,519 phosphoproteins were quantified. Compared with HL goslings, HH goslings exhibited elevated phosphorylation of muscle structural proteins (e.g., MYOM2 Thr614, Lamin A/C Ser299), cytoskeletal proteins (e.g., PDLIM7 Ser126, FLN Ser1524), and MAPK signaling components (p38-MAPK Thr180), correlating with higher fiber density. Conversely, HL goslings showed increased phosphorylation of kinases and energy metabolism proteins (e.g., CaMK Thr288, PGM1 Thr507/Ser408), consistent with enhanced fiber hypertrophy. KEGG enrichment indicated involvement of actin cytoskeleton regulation, MAPK signaling, and glycolysis/gluconeogenesis pathways. Overall, these results suggest that phosphorylation-mediated regulation may contribute to inter-individual differences in muscle fiber number and size during early development. - Source: PubMed
Publication date: 2026/03/02
Weng KaiqiLiu YiWang HuiyingXu QiHe Daqian - Salidroside, a valuable plant-derived glycoside, holds great promise for nutraceutical and pharmaceutical applications. Although microbial biosynthesis has been established, further enhancement of its production faces a universal bottleneck in glycoside synthesis: the competition for the glycosyl donor UDP-glucose (UDPG) between essential cell wall construction and target product formation. To overcome this fundamental conflict, we constructed a high-yielding microbial cell factory through a systematic engineering strategy. We first rewired central metabolism via a thiamine diphosphate (ThDP) regeneration strategy to secure a high-level production of the precursor tyrosol. Subsequently, the introduction of a glycosyltransferase U8GT33 from enabled the conversion of tyrosol to salidroside. To address the key limitation, we enhanced UDP-glucose availability by overexpressing UDP-glucose pyrophosphorylase (UGP1) and phosphoglucose mutase (PGM1), and most critically implemented cell wall engineering to dynamically redirect carbon flux from biomass synthesis toward salidroside production by regulating β-1,3-glucan synthase (FKS1) expression. This approach effectively decouples growth pressure from the synthesis demand. Subsequent engineering steps alleviated physiological constraints, yielding a robust production host. In a bioreactor fermentation, the final strain achieved a record-breaking salidroside titer of 40.46 g/L, with a productivity of 0.24 g/(L h) and a yield of 0.27 g/g glucose. This work demonstrates the efficacy of cofactor and cell wall engineering in optimizing glycoside production and provides a scalable strategy for the microbial manufacturing of high-value natural glycosides. - Source: PubMed
Publication date: 2026/03/12
Li JianLi HonghaoDai XiaoranMa HeMa ChenxiLuo Yunzi