Ask about this productRelated genes to: PGLYRP3 antibody
- Gene:
- PGLYRP3 NIH gene
- Name:
- peptidoglycan recognition protein 3
- Previous symbol:
- -
- Synonyms:
- PGRPIA, PGLYRPIalpha, PGRP-Ialpha
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-17
- Date modifiied:
- 2016-10-05
Related products to: PGLYRP3 antibody
Related articles to: PGLYRP3 antibody
- Cervical cancer (CC) remains a significant global health burden among women, particularly in cases of advanced or recurrent disease. Current clinical parameters exhibit suboptimal accuracy in predicting disease progression. Given that HPV integration is a well-established oncogenic driver in cervical carcinogenesis, there is growing interest in leveraging HPV-related molecular signatures to improve risk stratification and guide personalized treatment strategies. - Source: PubMed
Publication date: 2025/10/22
Yang YifanSun ChaoyangWang Hui - BACKGROUND: The Holstein Friesian (HF) cattle breed is the most dominant breed in commercial dairy farming worldwide and managed in more than 150 countries. These countries span diverse agro-climatic zones, ranging from tropical to cold regions. The introduction of HF animals in these regions occurred at different moments in the past which are poorly recorded and continued through importation of live animal and frozen semen. We hypothesize that the HF cattle populations in these regions underwent early forms of adaptation to these specific local environments. However, the detection of genetic variation associated with this adaptation remains poorly documented. RESULTS: This study investigates genetic relationship and potential early selection signatures in HF populations from three African countries (Egypt, South Africa, Uganda) and three European countries (Finland, Portugal, The Netherlands), considering five animals per country. Approximately 16.0 million single nucleotide polymorphisms (SNPs) were detected in the 30 HF animals and used for further analyses. Across all countries, we identified dispersed regions totaling 3.3 megabase of ecosystem-specific genomic regions (43 genes), indicative of early selection signatures based on fixation indices (F-statistic, Fst). Furthermore, comparing variants between tropical (Egypt and Uganda) and cold regions (Finland and The Netherlands) by Fst, nucleotide diversity (θπ ratio), and extended haplotype homozygosity (XP-EHH), we identified a total of 10 candidate regions, comprising 12 genes within a 0.57 megabase size. The regions were enriched with genes involved in signaling pathways associated directly or indirectly with adaptation, including the immune system (PGLYRP4,PGLYRP3, PAG1, CD48, SLAMF1, DYSF,and LOC615223), organ development and reproduction (LDB3, ADAMTSL4, TPRN, CCDC40, OR2AG1G, and OR8B3), thermogenic activation (TBC1D16), phospholipid metabolism (PLPPR4 and PITPNB), thermos-tolerance (ZNF423), and stimulus response (NCOA7, CYP2C85, and ARFGEF3). CONCLUSION: This study provides new insights into early forms of genetic plasticity of animals adapted to very diverse ecosystems. Our findings highlight candidate genes related to immune response, organ development, reproduction, metabolism, and thermo-tolerance, hypothesizing their role in facilitating adaptation to different environments. - Source: PubMed
Publication date: 2025/07/01
Gao JunxinGonzalez-Prendes RaynerLiu YingKantanen JuhaGinja CatarinaGhanem NasserKugonza Donald RugiraMakgahlela MahlakoBovenhuis HenkGroenen Martien A MCrooijmans Richard P M A - Clinical biomarkers such as fasting glucose, HbA1c, and fasting insulin, which gauge glycemic status in the body, are highly influenced by diet. Indians are genetically predisposed to type 2 diabetes and their carbohydrate-centric diet further elevates the disease risk. Despite the combined influence of genetic and environmental risk factors, Indians have been inadequately explored in the studies of glycemic traits. Addressing this gap, we investigate the genetic architecture of glycemic traits at genome-wide level in 4927 Indians (without diabetes). Our analysis revealed numerous variants of sub-genome-wide significance, and their credibility was thoroughly assessed by integrating data from various levels. This identified key effector genes, ZNF470, DPP6, GXYLT2, PITPNM3, BEND7, and LORICRIN-PGLYRP3. While these genes were weakly linked with carbohydrate intake or glycemia earlier in other populations, our findings demonstrated a much stronger association in the Indian population. Associated genetic variants within these genes served as expression quantitative trait loci (eQTLs) in various gut tissues essential for digestion. Additionally, majority of these gut eQTLs functioned as methylation quantitative trait loci (meth-QTLs) observed in peripheral blood samples from 223 Indians, elucidating the underlying mechanism of their regulation of target gene expression. Specific co-localized eQTLs-meth-QTLs altered the binding affinity of transcription factors targeting crucial genes involved in glucose metabolism. Our study identifies previously unreported genetic variants that strongly influence the diet-glycemia relationship. These findings set the stage for future research into personalized lifestyle interventions integrating genetic insights with tailored dietary strategies to mitigate disease risk based on individual genetic profiles. - Source: PubMed
Publication date: 2024/09/04
Nair Janaki MBandesh KhushdeepGiri Anil KPrasad GauriRajashekhar DonakaJha PunamBasu AnalabhaTandon NikhilBharadwaj Dwaipayan - During tail regeneration in lizards the new corneous layer formed in the regenerating epidermis includes antimicrobial peptides, cystatin and serpins, likely forming an anti-microbial barrier. The present study aims to reveal other proteins potentially contributing to this protective barrier of the epidermis. Using immunohistochemistry we have detected a peptidoglycan-like recognition protein-3 (pglyrp3), an antimicrobial molecule, and an epidermal growth factor receptor kinase 8 l (eps8l), a receptor of EGF (Epidermal Growth Factor) that stimulates epidermal formation. The study shows that the two proteins are mostly accumulated in the forming wound epidermis and in the shedding layer of the regenerating scales. The shedding layer is the intra-epidermal layer that allows the separation of the initial corneous layer from the regenerating epidermis. While presence of pglyrp3 is likely related to the formation of the anti-microbial barrier, the function of the eps8l protein in epidermal regeneration remains unknown. Whether the latter protein is involved in keratinocyte movement within the regenerating epidermis has to be specifically determined in future studies. Together with the antimicrobial peptides cystatin and serpins, previously detected in the wound epidermis and shedding layer, the present study indicates that pglyp3, and potentially eps8l, contribute to protect the new skin and underlying regenerated tissues from the potential microbe invasion. - Source: PubMed
Publication date: 2023/02/21
Alibardi Lorenzo - Esophageal cancer (EC) is a common malignant tumor of the digestive system with high mortality and morbidity. Current evidence suggests that immune cells and molecules regulate the initiation and progression of EC. Accordingly, it is necessary to identify immune-related genes (IRGs) affecting the biological behaviors and microenvironmental characteristics of EC. - Source: PubMed
Publication date: 2022/12/23
Li ChunzhenZhou WeizhengZhu JiShen QiWang GuangjieChen LingZhao Tiejun