Ask about this productRelated genes to: PDIA3 antibody
- Gene:
- PDIA3 NIH gene
- Name:
- protein disulfide isomerase family A member 3
- Previous symbol:
- GRP58
- Synonyms:
- P58, ERp61, ERp57, ERp60, GRP57, PI-PLC, HsT17083
- Chromosome:
- 15q15.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-06-09
- Date modifiied:
- 2016-10-05
- Gene:
- PDIA3P1 NIH gene
- Name:
- protein disulfide isomerase family A member 3 pseudogene 1
- Previous symbol:
- PDIA3P
- Synonyms:
- GRP58P
- Chromosome:
- 1q21.1
- Locus Type:
- pseudogene
- Date approved:
- 1997-07-22
- Date modifiied:
- 2015-11-16
Related products to: PDIA3 antibody
Related articles to: PDIA3 antibody
- d-Limonene, a type of natural extract obtained from citrus oils, was reported to have anti-cancer effects and be well-tolerated by cancer patients. Despite arousing interest as a cancer chemopreventive substance, the transcriptomic profile of d-limonene in humans is poorly understood. Based on the results of the transcriptomic profiling, a lncRNA named protein disulfide isomerase family A member three pseudogene (PDIA3P1) was found to be regulated by d-limonene. PDIA3P1 is an oncogene verified by three lung adenocarcinoma (LUAD) datasets. The knockdown of PDIA3P1 with siRNA decreased the viability, invasion, migration, and proliferation of LUAD cells. Based on The Cancer Genome Atlas (TCGA) LUAD datasets, PDIA3P1 regulates functions and pathways mainly including lipid metabolism, immunity, and the change of the chromosome structure. This study comprehensively performs the transcriptomic analysis of the d-limonene regulation on LUAD, and reveals that PDIA3P1 may be the mediator in helping d-limonene to prevent and suppress LUAD via lipid metabolism, immunity pathway, and the change in the chromosome structure. - Source: PubMed
Publication date: 2020/08/10
Feng TienanZhang QiLi QiangZhu TengtengLv WenwenYu HerbertQian Biyun - DNA damage-induced NF-κB activation is a major obstacle to effective antitumour chemotherapy. Long noncoding RNAs (lncRNAs) that regulate chemoresistance of cancer cells remain largely unknown. This study aimed to characterize the lncRNAs that may affect chemotherapy sensitivity. - Source: PubMed
Publication date: 2019/10/23
Xie ChenZhang Li-ZhenChen Zhan-LiZhong Wang-JingFang Jian-HongZhu YingXiao Man-HuanGuo Zhi-WeiZhao NaHe XiongleiZhuang Shi-Mei - Pseudogenes are a subclass of long non-coding (lnc) RNAs that arose from protein-coding genes, but have lost the ability to produce proteins. Pseudogenes play an important role in the pathogenesis of various tumors; however, the role of pseudogenes in hepatocellular carcinoma (HCC) is poorly understood. In this study, we investigated a novel pseudogene, PDIA3P1, which was upregulated in HCC tissues compared with paired normal adjacent tissues. The expression of PDIA3P1 was significantly correlated with tumor size, metastasis, TNM stage, and overall stage. Knockdown of PDIA3P1decreased proliferation, migration, and invasion of HCC cells. PDIA3P1 knockdown also promoted cell apoptosis and inhibited tumor growth in vivo. We performed a GeneChip assay to investigate the underlying mechanism of PDIA3P1 action on biological function, and our results suggested that PDIA3P1 may promote proliferation and inhibit apoptosis of liver cancer cells by inhibiting the p53 pathway. Thus, our data suggest that PDIA3P1 acts as an oncogene in HCC and could be a potential prognostic marker and therapeutic target for HCC. - Source: PubMed
Publication date: 2017/08/18
Kong YangZhang LufeiHuang YuHe TianyuZhang LinshiZhao XinyiZhou XiaohuZhou DongkaiYan YingcaiZhou JiarongXie HaiyangZhou LinZheng ShusenWang Weilin