Ask about this productRelated genes to: PDHB antibody
- Gene:
- PDHB NIH gene
- Name:
- pyruvate dehydrogenase E1 beta subunit
- Previous symbol:
- -
- Synonyms:
- PDHE1B
- Chromosome:
- 3p14.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2017-08-08
Related products to: PDHB antibody
Related articles to: PDHB antibody
- Cuproptosis is defined as a novel form of regulated cell death triggered by copper accumulation, with emerging evidence linking cuproptosis-related genes (CRGs) to tumor progression. However, the prognostic relevance of CRGs in papillary renal cell carcinoma (PRCC) remains elusive. This study aimed to construct and validate a cuproptosis-related gene prognostic signature for PRCC, and to explore its potential value in risk stratification, immune infiltration, and pathogenesis. - Source: PubMed
Li HaixiaCao LiLi RuiminXu LingZhang ShuxiaGao JianjunChen YongxueLian Xiaoqiang - Controlling abdominal fat accumulation and appetite have consistently been key research priorities in aquaculture. The melanocortin-4 receptor (MC4R) plays a crucial role in regulating appetite and lipid metabolism. In teleost fish, such as goldfish, there are two or more homologs of MC4R, yet the functions and significance of these homologs remain incompletely understood. To address this, we chose goldfish as a model organism and investigated the functions of caMC4R (Carassius auratus MC4R) and caMC4R-like using molecular docking, RNA interference (RNAi) and RNA sequencing (RNA-seq). Our findings indicate that the third intracellular loop (ICL3) of caMC4R and caMC4R-like differs significantly, resulting in distinct activation of cAMP signaling downstream of the receptor. The knockdown of caMC4R/caMC4R-like promoted appetite and growth in goldfish. Interestingly, the knockdown of caMC4R enhanced muscle lipid accumulation by regulating the expression of pyruvate dehydrogenase (E1) component subunit beta (PDHB). The knockdown of caMC4R-like promoted hepatic lipid accumulation via the PPARγ and SREBP-1c pathways. Overall, the knockdown of caMC4R and caMC4R-like promoted lipid accumulation in the muscle and liver of goldfish, respectively. The results of this study will provide foundational data for investigating the functions of the MC4R subfamily in teleost fish and the significance of genome duplication in fish evolution. In addition, our findings offer actionable insights for enhancing growth performance and modulating body composition in cultured fish populations, offering tangible applications for both nutritional programming and selective breeding in aquaculture production systems. - Source: PubMed
Publication date: 2026/05/07
Mo HaolinLv BowenLiu YanpengYu HuixiaDu YuyouWang XuGao JiuweiYao MingxingZhang QianqingYu JiajiaLi YangWang Lixin - Mitochondrial dysfunction is an emerging metabolic hallmark of age-related diseases, yet tools to directly profile mitochondrial pathways and test metabolic interventions in the living human eye remain limited. Multi-omics ocular liquid biopsy enables real-time proteomic and metabolomic profiling of the intraocular microenvironment, complementing systemic biomarkers and imaging surrogates. Here, we used this approach to define mitochondrial and tricarboxylic acid (TCA) cycle dysregulation in geographic atrophy (GA) and to assess whether oral α-ketoglutarate (α-KG) supplementation can modulate mitochondrial metabolites within the eye. - Source: PubMed
Publication date: 2026/03/19
Yeh Tsai-ChuVelez GabrielPrasad ArchiteshLee Soo HyeonRasmussen Ditte KKumar AarushiChadha MadhumeetaDabaja Mohamed ZiadSingh Aneal MSanislo StevenSmith StephenMryuthyunjaya PrithviMontague ArtisBassuk Alexander GAlmeida DavidDufour AntoineMahajan Vinit B - Glioblastomas (GBM) are highly aggressive, treatment-resistant brain tumors lacking clinically actionable, noninvasive prognostic biomarkers. Tumor response after standard-of-care chemoradiation (CRT) is difficult to interpret on imaging, and post-CRT MRI changes have not been well linked to molecular features or potential biomarkers. - Source: PubMed
Publication date: 2026/03/18
Krauze AndraNguyen TrinhSierk MichaelJackson LukeChappidi ShreyaChen QingrongYan ChunhuaHu YingHarmon StephanieTasci ErdalCooley TheresaSproull MaryMackey MeganMeerzaman DaoudCamphausen Kevin - Pulmonary fibrosis (PF), a progressive interstitial lung disease with elusive pathogenesis, remains a therapeutic challenge. Emerging evidence suggests cuproptosis-a copper-dependent cell death pathway-may play a regulatory role in disease progression. This study aims to elucidate cuproptosis's biological function and establish a prognostic model for PF. Through integrative analysis of single-cell RNA-seq data from bleomycin (BLM)-induced mouse models and bulk RNA-seq data from idiopathic pulmonary fibrosis (IPF) patients, we identified cuproptosis-related genes (CRGs) using LASSO regression and Cox regression. A novel 4-CRG signature (LIAS, LIPT1, ATP7A, PDHB) was constructed to stratify patients into distinct risk groups in the GSE70866 cohort, where high-risk individuals exhibited poorer survival and enhanced extracellular matrix/lipid metabolism activity via GO/KEGG analysis. Experimental validation in BLM-induced mouse models, TGF-β1-stimulated fibroblast-to-myofibroblast transition assays, and human IPF specimens demonstrated significant downregulation of CRGs through qRT-PCR and immunohistochemical analyses. Functional assays revealed impaired cell viability and elevated cuproptosis markers in fibrotic microenvironments. Our findings establish an inverse correlation between cuproptosis and PF progression, and propose a robust risk-score model for clinical prognosis prediction. This multi-omics approach provides new insights into copper-mediated regulatory mechanisms in fibrogenesis. - Source: PubMed
Publication date: 2026/03/13
Chen MengtingChen JialuZhang JiaxiangZhu YongMeng XiaoxiaoYang ZhengfengWang Ruilan