Ask about this productRelated genes to: PCSK4 antibody
- Gene:
- PCSK4 NIH gene
- Name:
- proprotein convertase subtilisin/kexin type 4
- Previous symbol:
- -
- Synonyms:
- PC4, SPC5, DKFZp434B217, MGC34749
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-19
- Date modifiied:
- 2015-09-03
Related products to: PCSK4 antibody
Related articles to: PCSK4 antibody
- Poorly differentiated endometrial carcinoma in Black African women is under-characterized at the transcriptomic level, although it is known for aggressive subtypes. We conducted the first RNA-seq analysis of formalin-fixed, paraffin-embedded (FFPE) tumors from Black South African women to explore population-specific gene expression, alternative splicing, and novel isoforms. - Source: PubMed
Publication date: 2026/03/24
Molefi ThuloAlaouna MohammedChipiti TalentSebitloane HannahDlamini Zodwa - Can genome-wide genotyping data be analysed using a hypothesis-driven approach to enhance the understanding of the genetic basis of severe spermatogenic failure (SPGF) in male infertility? - Source: PubMed
Publication date: 2024/11/13
Guzmán-Jiménez AndreaGonzález-Muñoz SaraCerván-Martín MiriamGarrido NicolásCastilla José AGonzalvo M CarmenClavero AnaMolina MartaLuján SaturninoSantos-Ribeiro SamuelVilches Miguel ÁngelEspuch AndreaMaldonado VicenteGaliano-Gutiérrez NoeliaSantamaría-López EstherGonzález-Ravina CristinaQuintana-Ferraz FernandoGómez SusanaAmorós DavidMartínez-Granados LuisOrtega-González YaniraBurgos MiguelPereira-Caetano IrisBulbul OzgurCastellano StefanoRomano MassimoAlbani ElenaBassas LluísSeixas SusanaGonçalves JoãoLopes Alexandra MLarriba SaraPalomino-Morales Rogelio JCarmona F DavidBossini-Castillo Lara - Testicular development and spermatogenesis play critical roles in male fertility and sexual maturation. To explore the genetic basis and key genes related to sexual maturity, we measured serum testosterone content and analysed testis tissue sections of Large White (LW) and Tongcheng (TC) boars at an immature age. We then screened differentially expressed genes (DEGs) in testis development in both breeds using RNA-seq. Finally, we analysed the selection signatures of both breeds to investigate which DEGs were subjected to positive selection. Our findings showed that serum testosterone contents in TC pigs (~4 ng/mL) were much higher than those in LW pigs (<0.95 ng/mL). Haematoxylin and eosin staining of testicular sections showed that the cross-sectional areas and perimeters of the seminiferous tubules in TC testes were larger and longer than those in LW pigs. A total of 5068 DEGs were selected by filtering criteria of q value <0.05 and |log (fold change)| ≥ 1. Gene Ontology analysis revealed that 250 genes were enriched in 11 biological process categories involved in sexual maturity. Most candidate genes, including TRIP13, NR6A1, STRA8, PCSK4, ACRBP, TSSK1B and TSSK6, were under positive selection. These results provide a better understanding of the genetic basis for testicular maturation and are useful for enhancing boar reproductive traits through molecular breeding. - Source: PubMed
Publication date: 2023/05/15
Li Xiu-LingWu QingqingWang TengfeiZhang LingyanWu XianmengZhang YuLiang WanDu XiaoyongLiu Xiao-LeiZhou XiangLiu Bang - Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases: PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in cardiovascular disease. Here, we aimed to investigate the expression landscape and druggability potential of the entire PCSK family for CVD. We applied an integrative approach, combining genetic, transcriptomic and proteomic data from three vascular biobanks comprising carotid atherosclerosis, thoracic and abdominal aneurysms, with patient clinical parameters and immunohistochemistry of vascular biopsies. Apart from , all PCSK family members lie in genetic regions containing variants associated with human cardiovascular traits. Transcriptomic analyses revealed that , were downregulated, while were upregulated in plaques vs. control arteries. In abdominal aneurysms, , , were downregulated, while was enriched in diseased media. In thoracic aneurysms, only was significantly upregulated. Network analyses of the upstream and downstream pathways related to PCSKs were performed on the omics data from vascular biopsies, revealing mechanistic relationships between this protein family and disease. Cell type correlation analyses and immunohistochemistry showed that PCSK transcripts and protein levels parallel each other, except for PCSK9 where transcript was not detected, while protein was abundant in vascular biopsies. Correlations to clinical parameters revealed a positive association between plaque levels and serum LDL, while was negatively associated with Hb. were all positively associated with adverse cardiovascular events. Our results show that is abundant in plaques and abdominal aneurysms, while upregulation is characteristic for thoracic aneurysms. PCSK9 protein, but not the transcript, was present in vascular lesions, suggesting its accumulation from circulation. Integrating our results lead to the development of a novel 'molecular' 5D framework. Here, we conducted the first integrative study of the proprotein convertase family in this context. Our results using this translational pipeline, revealed primarily PCSK6, followed by PCSK5, PCSK7 and FURIN, as proprotein convertases with the highest novel therapeutic potential. - Source: PubMed
Publication date: 2022/09/15
Suur Bianca EChemaly MelodyLindquist Liljeqvist MoritzDjordjevic DjordjeStenemo MarkusBergman OttoKarlöf EvaLengquist MarietteOdeberg JacobHurt-Camejo EvaEriksson PerKetelhuth Daniel F JRoy JoyHedin UlfNyberg MichaelMatic Ljubica - Uterine corpus endometrial carcinoma (UCEC) is a gynecological malignant tumor with low survival rate and poor prognosis. The traditional clinicopathological staging is insufficient to estimate the prognosis of UCEC. It is necessary to select a more effective prognostic signature of UCEC to predict the prognosis and immunotherapy effect of UCEC. - Source: PubMed
Publication date: 2021/12/14
Liu JinhuiGeng RuiYang ShengShao FangZhong ZihangYang MinNi SenmiaoCai LixinBai Jianling