Ask about this productRelated genes to: PCK1 antibody
- Gene:
- PCK1 NIH gene
- Name:
- phosphoenolpyruvate carboxykinase 1
- Previous symbol:
- -
- Synonyms:
- PEPCK-C
- Chromosome:
- 20q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-09-10
- Date modifiied:
- 2015-12-16
Related products to: PCK1 antibody
Related articles to: PCK1 antibody
- Traditional Chinese medicines (TCMs) demonstrate efficacy in hyperlipidemia prevention and treatment, irrespective of their traditional classifications. However, the molecular mechanisms underlying their hypolipidemic activities remain incompletely defined. This study investigates the lipid-lowering effects and associated mechanisms of three clinically applied TCMs: Citrus reticulata Blanco (Citri Reticulatae Pericarpium, CRP), Nelumbo nucifera Gaertn. (Nelumbinis Folium, NF), Alisma orientale (Sam.) Juzep. (Alismatis Rhizoma, AR). - Source: PubMed
Publication date: 2026/05/14
Wang Xiao-LeLi Jia-YunGuo Yu-HanZhai Guo-HaoFang Ni-YuanPeng Miao-MiaoChen Neng-YuQin BingChen Qian-QianLiu E-Hu - Clear cell renal cell carcinoma (ccRCC) is the most common renal carcinoma subtype. Aging-related genes (ARGs) are implicated in ccRCC progression, though their mechanisms remain unclear. This study aimed to elucidate the molecular mechanisms of ARGs in ccRCC and identify potential prognostic biomarkers and therapeutic targets. Transcriptomic data from the cancer genome atlas (TCGA-ccRCC) cohort were analyzed. differentially expressed genes and ARGs were intersected to identify candidate genes. Prognostic ARGs were then screened using machine learning algorithms. A risk model was constructed and validated through survival analysis, stratifying patients into high- and low-risk groups. Functional enrichment, immune infiltration, and drug prediction analyses were performed. The expression levels of prognostic genes in ccRCC tissues were validated through reverse transcription quantitative polymerase chain reaction (RT-qPCR). A total of 2312 differentially expressed genes and 307 ARGs were identified, of which 25 overlapping genes were selected as candidates. Seven ARGs were significantly associated with patient prognosis: protective PCK1, and risk-related TOP2A, TFAP2A, CCNA2, FOXM1, CDKN2A, and PLAU. High-risk patients showed reduced overall survival rates. Immune infiltration and checkpoint expression differed significantly between risk groups. decision curve analysis indicated high clinical utility. Drug prediction identified 69 potential therapeutic compounds, including tyrosine kinase and mTOR inhibitors. RT-qPCR validated 5 genes' expression, consistent with bioinformatics predictions, though discrepancies were observed in the expression patterns of FOXM1 and CDKN2A. Seven ARGs were identified as key prognostic markers in ccRCC. A robust risk model was established, providing insights into ARG-related mechanisms and potential diagnostic and therapeutic strategies. - Source: PubMed
Liu ChenShuang WeibingCao XiaomingGao Ying - Advanced glycation end products (AGEs) are significant byproducts of the Maillard reaction and are implicated in degenerative diseases. Catechin (CC), a dietary polyphenol distributed in fruits and vegetables, inhibits AGEs formation through binding with carbonyl compounds. However, the biological role of these binding adducts remains unclear. This study first isolated the major CC-methylglyoxal (MGO) adducts using high-speed counter-current chromatography. Structural analysis confirmed it retains antioxidant phenolic hydroxyls. In food models (lactose/lysine and milk), CC-MGO significantly inhibited AGEs formation, an effect that may be partly attributed to its antioxidant activity. In Caco-2 cells, CC-MGO alleviated AGEs-induced cytotoxicity. Transcriptomics revealed AGEs activated the AGE-RAGE pathway (upregulating CXCL8, CCL2), while CC-MGO counteracted toxicity by modulating PPAR and IL-17 pathways, specifically upregulating SLC27A5 and downregulating MMP1 and PCK1. These findings demonstrate that CC not only scavenges carbonyls but also forms bioactive adducts that further suppress AGEs formation and toxicity, providing a dual mechanism for natural intervention. - Source: PubMed
Publication date: 2026/05/04
Yan JiaZhang XingyuZhao XinruTan JiangyingBao ChenxuZhou ChenHe BoqianLi YinxinLu BaiyiLiu LianliangYi FanWu Qian - Abnormal glucose metabolism often contributes to myofibroblast activation and the pathogenesis of skin fibrotic diseases. All-trans retinoic acid (ATRA), the active component of tretinoin cream, can regulate glucose metabolism and activate myofibroblasts. Importantly, investigating the potential of ATRA to inhibit myofibroblast activation by modulating glucose metabolism could reveal the translational significance of ATRA in attenuating hypertrophic scar (HS) formation. - Source: PubMed
Publication date: 2026/04/27
Li Zi-ChaoZhu Yi-FuSong Ya-JuanTan Zhi-JunLiu BinJiang YanXiao Hou-AnZu Dong-MeiWang TongShi YiJiao YanLi Xue-YongXu Xing-BoShang LeiYu ZhouSong Bao-Qiang - Renal lipid metabolic dysregulation drives tubular injury and fibrosis in chronic kidney disease (CKD), yet endogenous targets governing tubular lipid homeostasis remain incompletely understood. This study aimed to elucidate how calycosin (CAL), an O-methylated isoflavone from Astragali Radix, corrects renal lipid metabolic dysregulation and attenuates fibrosis in CKD. - Source: PubMed
Publication date: 2026/04/30
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