Ask about this productRelated genes to: PAWR antibody
- Gene:
- PAWR NIH gene
- Name:
- pro-apoptotic WT1 regulator
- Previous symbol:
- -
- Synonyms:
- par-4, PAR4
- Chromosome:
- 12q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-05
- Date modifiied:
- 2016-03-10
Related products to: PAWR antibody
Related articles to: PAWR antibody
- Culturally grounded physical education provides meaningful opportunities to connect movement, heritage, and student engagement. This study examined the association between individual interest and study engagement in Filipino recreational games-based physical education among university students in the Philippines. Filipino recreational games, locally known as , are traditional movement-based activities commonly integrated into PE to promote cultural appreciation and active participation. Guided by the tripartite model, individual interest was conceptualized through three factors: positive affect and willingness to reengage (PAWR), stored-utility value (SUV), and stored attainment value and knowledge-seeking intentions (SAVKSI). - Source: PubMed
Publication date: 2026/06/02
Lobo Joseph - PRKC Apoptosis WT1 Regulator (PAWR) has been implicated in tumorigenesis. However, its role in antiviral innate immunity remains unexplored. Here, we demonstrate that PAWR transcriptionally upregulates RIG-I expression through the transcription factor X-box binding protein 1 (XBP1). Mechanistically, PAWR potentiates the ATF6/IRE1-XBP1 pathway to upregulate spliced form XBP1 (XBP1s) and simultaneously promotes PIM2-mediated phosphorylation of XBP1s at Ser68. Activated XBP1s binds the RIG-I promoter, driving RIG-I expression and amplifying IFN-I responses during RNA virus infection. Most intriguingly, PAWR-silenced THP-1 cells and primary macrophages exhibit attenuated anti-RNA viral IFN-I responses. Pawr-deficient mice are more susceptible to RNA virus challenge. Notably, Arylquin 1, the small molecule activator of PAWR, inhibits VSV replication by boosting the RIG-I-mediated IFN-I response in a PAWR-dependent manner. Collectively, our findings highlight a critical function of PAWR in antiviral innate immunity via the PIM2-XBP1s-RIG-I signaling axis, establishing its potential as a promising therapeutic target for RNA viral infections. - Source: PubMed
Publication date: 2026/06/11
Hou PeiliSun XiaonanZhu HongchaoFeng YueyueLi RuiWang XiaoyunZhang FuzhenWang JunHan YuanyuanHe Daniel ChangWang HongmeiHe Hongbin - Body mass index (BMI) is an important composite trait reflecting fat and muscle deposition, which is closely related to feed efficiency, carcass composition, and overall production performance in pigs. Optimizing BMI is crucial for achieving balanced growth and desirable meat quality in modern pig breeding programs. While numerous genetic loci associated with BMI have been reported in humans, studies in livestock remain scarce, and the genetic and regulatory mechanisms driving BMI variation are still largely unknown. To address this, we conducted genome-wide association study on 4,519 pigs representing three commercial breeds (Yorkshire, Landrace, and Duroc), performing analyses both at the single-breed level and in the combined population. By integrating Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq), Chromatin Immunoprecipitation followed by Sequencing (ChIP-seq), and in situ Hi-C followed by chromatin immunoprecipitation (HiChIP) datasets for functional genomics analyses, we identified five quantitative trait loci with potential regulatory function, two of which are homologous to enhancer regions in the human genome. We further prioritized a set of high-confidence candidate genes, including OSBPL10, PCCA, MYPN, PAWR, and PCDH7, which are closely associated with lipid metabolism and muscle development. These findings reflect breed differences in body composition, provide targets for improving meat production efficiency through breeding, and offer insights into the genetic and regulatory mechanisms underlying human metabolic disorders. - Source: PubMed
Huang YaniZhou WeiweiLi JingquanWu FushengXiao ShijunZhang Zhiyan - BACKGROUND: Proteins represent the dynamic downstream products of genes, and have the potential to substantially increase understanding of the complexities of cancer biology. Undifferentiated pleomorphic sarcoma (UPS) is a rare disease, the proteomic landscape of which has not been fully investigated. METHODS: We performed isobaric TMT-based proteomic analysis for 80 UPS tumor and 28 corresponding adjacent non-tumor muscle tissues. The underlying molecular subtypes, therapeutic targets, local recurrence, and lung metastasis were uncovered. The integration of previous single-cell RNA sequencing data with proteomics was further employed to characterize the specific cell type linked to lung metastasis. RESULTS: Our analyses revealed a catalog of proteins that were dysregulated in UPS. The UPS cohort was stratified into three molecular subtypes S-I, S-II, and S-III. S-I was characterized by the high expression of spliceosome-related proteins and protumor cytokines, and was associated with the lowest overall rate of survival. S-II was characterized with the highest ImmuneScore. S-III with the highest StromaScore had the best outcomes. Protein-based disease classification was better than the recommended AJCC staging system for UPS. PRMT6 protein was overexpressed, and associated with adverse outcomes. PRMT6 inhibitor significantly inhibited tumor growth in two patient-derived xenograft models. Analysis of local recurrence-associated proteins showed that PAWR was negatively associated with UPS recurrence. Additionally, CD163 was a negative predictive marker for lung metastasis. Combined with scRNA-seq data, CD163 + macrophages represented phagocytosis phenotype with high expression of the signature markers (CD163, MRC1, MERTK, and C1QB). Furthermore, CD163 + macrophages were enriched in the endocytosis, phagocytosis, and lysosome compared with CD163- macrophages. CONCLUSIONS: Our study highlights the utility of proteomics for characterizing UPS, providing a framework for understanding the biological basis of its clinical features and paving the way for a new era of proteomics-driven precision medicine in sarcoma research. - Source: PubMed
Publication date: 2026/03/20
Zheng BiqiangLu YifeiWang BingnanChai WenjunYan MingxiaSong ZhijianYan Wangjun - Colorectal cancer (CRC) progression occurs through three stages: adenoma (pre-cancerous lesion), carcinoma in situ (CIS) and adenocarcinoma, with tumor stage playing a pivotal role in the prognosis and treatment outcomes. Despite therapeutic advancements, the lack of stage-specific biomarkers hinders the development of accurate diagnostic tools and effective therapeutic strategies. This study aims to identify stage-specific gene expression profiles and key molecular mechanisms in CRC providing insights into molecular alterations across disease progression. Our methodological approach integrates the use of absolute gene set enrichment analysis (absGSEA) on formalin-fixed paraffin-embedded (FFPE)-derived transcriptomic data, combined with large-scale clinical validation and experimental confirmation. A comparative whole transcriptomic analysis (RNA-seq) was performed on FFPE samples including adenoma ( = 10), carcinoma in situ (CIS) ( = 8) and adenocarcinoma ( = 11) samples. Using absGSEA, we identified significant cellular pathways and putative molecular biomarkers associated with each stage of CRC progression. Key findings were then validated in a large independent CRC patient cohort ( = 1926), with survival analysis conducted from 1336 patients to assess the prognostic relevance of the candidate biomarkers. The key differentially expressed genes were experimentally validated using real-time PCR (RT-qPCR). Pathway analysis revealed that in CIS, apoptotic processes and Wnt signaling pathways were more prominent than in adenoma samples, while in adenocarcinoma, transcriptional co-regulatory mechanisms and protein kinase activity, which are critical for tumor growth and metastasis, were significantly enriched compared to adenoma. Additionally, extracellular matrix organization pathways were significantly enriched in adenocarcinoma compared to CIS. Distinct gene signatures were identified across CRC stages that differentiate between adenoma, CIS and adenocarcinoma. In adenoma, , and were overexpressed, suggesting their involvement in early tumorigenesis, whereas in CIS, and were overexpressed, suggesting their involvement in the transition from benign to malignant stage. In adenocarcinoma, , , and were overexpressed, suggesting their involvement in advanced disease progression. Functional analysis confirmed that and /2 were associated with early tumor development, while and were involved in extracellular matrix remodeling and transcriptional regulation, respectively. Experimental validation with RT-qPCR confirmed the differential expression of the candidate biomarkers (, , , and across the three CRC stages reinforcing their potential as stage-specific biomarkers in CRC progression. These findings provide a foundation to distinguish between the CRC stages and for the development of accurate stage-specific diagnostic and prognostic biomarkers, which helps in the development of more effective therapeutic strategies for CRC. - Source: PubMed
Publication date: 2025/04/28
Alhosani FaisalAlhamidi Reem SamiIlce Burcu YenerAltaie Alaa MuayadAli NivalHamad Alaa MohamedKünstner AxelKhandanpour CyrusBusch HaukeAl-Ramadi BaselHarati RaniaSayed KadriaAlFazari AliBendardaf RiyadHamoudi Rifat