Ask about this productRelated genes to: PARN antibody
- Gene:
- PARN NIH gene
- Name:
- poly(A)-specific ribonuclease
- Previous symbol:
- -
- Synonyms:
- DAN
- Chromosome:
- 16p13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-23
- Date modifiied:
- 2019-04-23
Related products to: PARN antibody
Related articles to: PARN antibody
- Lumbar spinal stenosis (LSS) affects over 100 million people globally, with an increasing incidence due to an ageing population. While LSS is known to be heritable, its genetic basis remains poorly understood. We conduct a genome-wide meta-analysis of LSS in 40,303 cases and 741,469 controls. We identify 73 previously unreported loci in addition to 15 known loci, and highlight spinal degeneration as a key pathogenic mechanism. In 12,784 surgically treated cases, we discover five loci specifically associated with severe disease. Age-of-onset analyses show that most variants influence risk after midlife, but some confer susceptibility as early as age 34. Mendelian randomization further demonstrates causal effects of higher body mass and fat-free mass on LSS risk. Overall, our findings expand knowledge of the genetic background of LSS and inform future translational research. - Source: PubMed
Publication date: 2026/04/06
Salo VilleMäättä JuhaniTakala JasminHeikkilä Anni Reimann EneMägi Reedik Reis KadriElhanas Abdelrahman GReigo AnuPalta PriitEsko TõnuLeinonen VilleKarppinen JaroSliz EevaKettunen Johannes - Sulfate in glycans often serves as a determinant of glycan-protein interactions underlying mammalian physiology. Sulfated glycoconjugates in mammals encompass proteoglycans, glycoproteins, and glycolipids, and more than 30 sulfotransferases catalyze carbohydrate sulfation. - Source: PubMed
Publication date: 2026/03/21
Parn Kim WaiAngata Takashi - The majority of pri-miRNAs acquire a 5' cap and 3' poly(A) tail. Mature miRNAs recruit deadenylases that shorten poly(Α) tails triggering target mRNA degradation. Poly(A)-specific ribonuclease (PARN) is a deadenylase that also mediates late steps of noncoding RNA maturation. Herein, we show that PARN affects the expression of a subset of miRNAs in NCI-H520 cells of lung cancer origin, including miR-29a and miR-1207, which are also predicted to target PARN mRNA. PARN associates with pri-miR-29a and pri-miR-1207 regulating their poly(A) lengths. Conversely, miR-29a-3p and miR-1207-5p bind the 3' UTR of PARN mRNA and regulate its expression. Cleavage and polyadenylation specificity factor 6 (CPSF6) recruits PARN to pri-miRNAs and together they affect primary and mature miR-29a-3p levels. Modulation of PARN, miR-29a-3p, or miR-1207-5p expression affects cell migration. We present a model to describe the dynamic relation between PARN and miR-29a and discuss its biological significance. - Source: PubMed
Publication date: 2026/03/13
Kyritsis AthanasiosBeta Rafailia AaScutelnic DianaStravokefalou VasilikiDel Vescovo ValerioArsenopoulou Zoi VPapikinos KonstantinosGrasso MargheritaFontana FrancescaMoutopoulou ParaskeviTsiporis AlexandrosSamiotaki MartinaPanayotou GeorgeDenti Michela ABalatsos Nikolaos Aa - A woman in her late 20s presented with a 5-year history of progressive fatigue and generalised weakness. Examination revealed signs of premature ageing, anaemia, neuropathy and hepatosplenomegaly.Investigations showed pancytopenia, dimorphic anaemia, severe vitamin B deficiency, hepatic fibrosis and pulmonary fibrosis. Despite correction of nutritional deficiencies, the constellation of cytopenia, premature greying, osteoporosis, hepatic and pulmonary fibrosis raised suspicion of a genetic disorder. Clinical exome sequencing identified a monoallelic missense variant (c.613T>C; p.Cys205Arg), classified as a Variant of Uncertain Significance. Germline pathogenic variants in have been associated with dyskeratosis congenita, autosomal recessive 6 (DKCB6) and with telomere-related pulmonary fibrosis and/or bone marrow failure 4. The clinical-genetic correlation in this case supported a diagnosis of a telomere biology disorder (TBD). This case highlights the importance of considering TBDs in young adults with unexplained multisystem disease, even when classical mucocutaneous features are absent. Early recognition is crucial for guiding genetic counselling, surveillance and consideration of bone marrow transplantation in progressive cases. - Source: PubMed
Publication date: 2026/02/25
Soni JinalSam Karun SaathveegTaneja VinusKhosla Pooja - - Source: PubMed
Publication date: 2026/01/23
Franco GiovanniBruno Lucia PiaAlviano Antonio MariaVankann LuciaBrümmendorf TimGuerra FabiolaVendemini FrancescaFaverio PaolaL'Imperio VincenzoCazzaniga GiovanniLuppi FabrizioBiondi AndreaBalduzzi AdrianaBeier FabianSaettini Francesco