Ask about this productRelated genes to: OPA3 antibody
- Gene:
- OPA3 NIH gene
- Name:
- outer mitochondrial membrane lipid metabolism regulator OPA3
- Previous symbol:
- -
- Synonyms:
- FLJ22187, MGA3
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 1999-03-12
- Date modifiied:
- 2019-04-08
Related products to: OPA3 antibody
Related articles to: OPA3 antibody
- Heart failure (HF) is a growing global health burden characterized by impaired cardiac contractility and progressive remodeling, driven in part by disrupted Ca handling and mitochondrial dysfunction. However, the molecular mechanisms coordinating these processes remain incompletely understood. Here we showed that OPA3 was decreased in both human and murine HF. Cardiomyocyte-specific deletion of Opa3 in male mice led to the progressive dilated cardiomyopathy (DCM), accompanied by impaired myocardial function, calcium cycling and mitochondria function. Mechanistically, OPA3 forms multimers that are required for its interaction with phospholamban (PLN), thereby maintaining sarcoplasmic reticulum (SR) Ca-ATPase (SERCA2a) activity and Ca handling. OPA3 is localized to the mitochondrial outer membrane, and its absence impaired mitochondrial function. Cardiomyocyte-specific overexpression of Opa3 improved cardiac dysfunction in both pressure overload- and doxorubicin-induced HF models. Our data define a critical role of OPA3-PLN-SERCA2a axis that regulates both mitochondria and SR function, representing a potential therapeutic target for HF. - Source: PubMed
Publication date: 2026/06/17
Geng NaChen TaiweiLi HaoLu ShanWang YuehongGao LingBers Donald MLu Xiyuan - Genome-wide association studies (GWAS) have identified numerous lung cancer susceptibility loci based on single nucleotide polymorphisms (SNPs), yet a substantial proportion of heritability remains unexplained. We therefore evaluated germline copy number variants (CNVs) as an underexplored source of genetic susceptibility and potential contributors to genomic instability in lung cancer. - Source: PubMed
Publication date: 2026/05/15
Xiao FeifeiQin FeiLuo XizhiSlewitzke Shannon EFernandes Gail FJohansson MattiasXiao XiangjunZaridze DavidBojesen Stig EgilShete SanjayAlbanes DemetriosAldrich Melinda CTardon AdoninaFernandez-Tardon GuillermoLe Marchand LoïcRennert GadBickeböller HeikeWichmann H-ErichRisch AngelaMuley ThomasRosenberger AlbertField John KDavies MichaelWoll PenellaKiemeney Lambertus AHaugen AageZienolddiny ShanbehLam StephenJohansson MikaelGrankvist KjellSchabath Matthew BAndrew AngelineLazarus PhilipArnold Susanne MZhu DakaiBrenner HermannNeuhouser Marian LHung Rayjean JChristiani David CMcKay JamesCai GuoshuaiXia JunAmos Christopher I - Autosomal dominant optic atrophy (DOA) is an inherited optic neuropathy characterized by progressive bilateral vision loss, cecocentral visual field (VF) defects, and retinal ganglion cell degeneration. Most cases are associated with mutations, while -related DOA is rare and typically involves both eyes. To date, unilateral disease has not been reported. - Source: PubMed
Publication date: 2025/12/11
Ware Matthaeus AntonyLi Haoran CharlesMicieli Jonathan - Acute and long-term mental health disorders correlate with coronavirus disease 2019 (COVID-19). The underlying mechanisms responsible for the coexistence of COVID-19 and depression remain unclear, and more research is needed to find hub genes and effective therapies. The main objective of this study was to evaluate gene-expression profiles and, identify key genes, and discovery potential therapeutic agents for co-occurrence in COVID-19 and major depressive disorder (MDD). - Source: PubMed
Publication date: 2025/08/22
Chen ShaojunLuo YiyuanZhang Lihua - The aim of this study was to evaluate the short- and long-term repeatability of a spectrophotometer and three mobile phone color applications (MCAs) on the iPhone Operating System (iOS) platform for color differences of single-shade and multi-shade resin materials of different thicknesses. - Source: PubMed
Publication date: 2025/07/16
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