Ask about this productRelated genes to: OCLN antibody
- Gene:
- OCLN NIH gene
- Name:
- occludin
- Previous symbol:
- -
- Synonyms:
- PPP1R115
- Chromosome:
- 5q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-20
- Date modifiied:
- 2016-10-05
Related products to: OCLN antibody
Related articles to: OCLN antibody
- Atopic dermatitis (AD) is increasingly recognized as a systemic inflammatory disorder linked to intestinal immune and microbiome dysregulation. However, whether dietary galactomannan fibers can mitigate AD through coordinated modulation of the gut-skin axis remains unexplored. This study investigated the anti-atopic potential of orally administered partially hydrolyzed guar gum (PHGG), a low-viscosity, fermentable galactomannan enriched in low-mass oligosaccharides (mannose/galactose ratio of 1.87). - Source: PubMed
Publication date: 2026/04/26
Kakooza DerrickYu HyeonjunJeong JonghyunShin Jung CheulKim Woo JungMoon Sung-KwonKim Hoon - The current number of emerging contaminants worldwide may reach tens of thousands. However, research on the extra-pulmonary toxicity induced by combined exposure of extremely low-dose emerging pollutants remains extremely limited. This study examined testicular injury induced by intratracheal instillation of two prevalent and frequently co-occurring emerging contaminants at ambient levels: polystyrene nanoparticles (PS) and perfluorooctane sulfonate (PFOS). With a 3 × 3 factorial design, male mice were intratracheally instilled with PS (0, 1.5 and 7.5 mg/kg) and/or PFOS (0, 5 and 25 μg/kg) once a week for 4 weeks. The instillation of PS in combination with PFOS induced more severe testicular histopathological injury, impairment of sperm counts and quality, reduced serum testosterone (T) levels and disruption of the blood-testis barrier (BTB). Furthermore, the testicular transcriptomic analysis identified the differentially expressed genes (DEGs) in the PS and PFOS co-exposure group, especially with Ldlr and Vegfd downregulation, and the DEGs were significantly enriched in vascular morphogenesis and development pathways and cholesterol metabolism pathways. In parallel, the protein expression of LDLR was decreased, the expression of testicular vascular endothelial markers (CD31 and VEGF) and tight junction proteins (ZO-1 and OCLN) was significantly reduced in the PS and PFOS co-exposure group compared with the control group (p < 0.05). Moreover, the testicular steroidogenic enzymes (StAR, CYP11A1, CYP17A1) were significantly reduced in the PS and PFOS co-exposure group compared with the control group (p < 0.05). Surprisingly, PS was detected in the testicular tissue in both PS and PS+PFOS groups. Our findings highlight an underappreciated risk of inhaling trace emerging pollutants mixtures on male fertility. - Source: PubMed
Publication date: 2026/04/23
Zhao LuweiChen YuweiPang GuanhuaLi YifeiHu RuokunXiao YuxinHe Miao - Porcine reproductive and respiratory syndrome virus (PRRSV) poses a persistent and devastating threat to the global swine industry. In China, NADC30-like PRRSV strains (Lineage 1.8) have undergone extensive and continuous recombination with field isolates and vaccine-derived strains, resulting in variants with altered pathogenicity and tissue tropism that severely complicate disease control and prevention efforts. In the present study, two novel NADC30-like PRRSV strains (PRRSV01-2024 and PRRSV02-2024) were isolated from piglets exhibiting respiratory and neurological symptoms in two distinct pig farms in Fujian Province, China. Genetic and recombination analyses revealed that both isolates are Lineage 1.8 strains derived from at least two rounds of inter-lineage recombination, with GDsf1707 (a Lineages 1.8 and 8.7 recombinant strain) serving as the major parental virus, while VR2332-like vaccine strain RespPRRS MLV as the minor parental virus. Animal studies indicated that both strains exhibited more severe clinical symptoms in piglets, including 20%-40% mortality, persistent fever, significant weight loss, higher viremia, and severe interstitial pneumonia compared with the moderately virulent NADC30-like strain FJZ03. More importantly, the two strains possessed a novel neurotropic phenotype, inducing neurological symptoms and severe neurological lesions, with PRRSV antigens and high viral loads (up to 10-10 copies/mg) detected in brain tissues. Furthermore, qPCR and four-color multiplex immunofluorescence staining revealed that both strains downregulated the expression of tight junction proteins (CLDN5, OCLN, and TJP1), thereby enabling them to cross the blood-brain barrier (BBB) into the central nervous system and infect glial cells. Taken together, these findings suggest that multi-round recombination increases the tissue tropism and virulence of PRRSV, underlining the importance of intensified molecular surveillance and targeted control strategies. - Source: PubMed
Publication date: 2026/04/20
Yang YuanLuo ChengYan YixueChen HaoyuXie FeiminWang ZiyiWei WeiCen MingshengChen XinyueHuang WenlinLan XinFeng YuWang QishenDai AilingWei ChunhuaLiu Jiankui - Broiler chicks of the same batch typically hatch over 24-48 h, not simultaneously. After hatching, exposure to suboptimal ambient temperatures, together with practices such as sexing, vaccination, and transport, delays their first feed and water intake, negatively impacting nutrient absorption and immune system development. Early nutrition strategies using lower Ca levels and highly digestible ingredients, like spray-dried porcine plasma, may mitigate these effects. This study compared a conventional hatchery system (CH) vs an on-farm hatching system (OFH) and three early feeding programmes on performance (pen-based), tibia mineralisation, and intestinal gene expression measured in representative male birds in Ross 308 broilers. Eggs from one breeder flock were divided as follows: 2 880 eggs at 18-day incubation were transported to the farm for OFH (initially 60 eggs/pen; 48 pens). At 21-day incubation (day 0), OFH pens were standardised to 39 chicks/pen (1 872 chicks total) to match conventional hatchery stocking density; surplus chicks were not enrolled. In parallel, 1 872 CH chicks from the same flock were transported ∼6 h (492 km) and placed in 48 pens. The study followed a three-way factorial design, including three starter feeding programmes-S1: standard starter (0-10 days); S2: enhanced pre-starter (0-4 days) followed by standard starter (4-10 days); and S3: enhanced pre-starter (0-4 days) followed by enhanced starter (4-10 days)-by two hatching systems (CH vs OFH), and by two sexes (female vs male). All birds received common grower (10-28 days) and finisher (28-42 days) diets. During the starter phase, OFH chicks showed higher BW and greater tibia weight, ash weight, length, and breaking strength (P < 0.05), but performed similarly to CH chicks by the end of the cycle (P > 0.05), with few differences in bone properties. Feeding programme S3 improved overall performance (P < 0.05) compared to S1 in both systems. Chicks fed the enhanced pre-starter diet exhibited upregulation of OCLN (P < 0.05), a gene associated with gut barrier integrity, compared with those on the standard diet. Chicks from CH showed higher expression (P < 0.05) of genes associated with immune response, barrier function, and stress adaptation, whereas OFH chicks showed gene expression patterns consistent with earlier intestinal maturation associated with immediate posthatch feed access. Overall, optimised early feeding strategies based on low-Ca levels and highly digestible ingredients improved broiler growth performance and supported intestinal and bone development, whereas the effects of hatching system were mainly confined to the early posthatch period. - Source: PubMed
Publication date: 2026/03/26
Franco-Rosselló RRodriguez-Navarro A BBenavides-Reyes CFarré MPolo JSolà-Oriol DGarcía-Ruiz A I - Necrotic enteritis (NE) is a widespread avian intestinal disease that causes substantial economic losses in poultry production. With increasing restrictions on antibiotic use, sustainable alternatives are urgently needed. Glycerol monolaurate (GML) has anti-inflammatory and antimicrobial properties, but its role in preventing NE remains unclear. This study aimed to investigate the protective effects of GML on gut-liver health and the cecal microbiota in NE-challenged broilers. - Source: PubMed
Publication date: 2026/04/18
Kong LinglianZhang XinranPan XueDong XueweiSong Zhigang