Ask about this productRelated genes to: NTF4 antibody
- Gene:
- NTF4 NIH gene
- Name:
- neurotrophin 4
- Previous symbol:
- NTF5
- Synonyms:
- NT-4/5, GLC1O
- Chromosome:
- 19q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-10-15
- Date modifiied:
- 2014-11-19
Related products to: NTF4 antibody
Related articles to: NTF4 antibody
- Schizophrenia (SCZ) and systemic lupus erythematosus (SLE) exhibit epidemiological overlap, suggesting shared genetic underpinnings. Using the largest SLE genome-wide association study (GWAS) to date, we identified a significant genetic correlation between SCZ and SLE (rg = 0.25, p = 9.0 × 10-4). Cross-trait analysis nominated multiple candidate shared loci outside the major histocompatibility complex (MHC), most with aligned effects. The strongest candidate shared association was found at the FURIN-FES locus, previously implicated in SCZ and newly associated with SLE. In addition to FURIN-FES, FCGR2A, DOT1L and an intergenic noncoding RNA locus on chromosome 2 showed additional evidence consistent with shared association. Functional annotation showed that this locus modulated the expression of FURIN, which encodes a proprotein convertase involved in diverse biological processes, and FES, which encodes a tyrosine kinase important in innate immune signalling. The shared risk allele was also associated with altered plasma levels of FURIN, FES, and their functional partners (GDF2, BMP10, NTF4, FER). Tissue- and cell-type-specific eQTL analysis revealed distinct regulatory effects: FURIN expression was perturbed in neuronal and immune cells, while FES expression was altered in immune cells. Mendelian randomisation supported a causal role for FES protein in both disorders. These findings highlight that pleiotropy at the FURIN-FES locus for SCZ and SLE is compatible with disease-specific mechanisms. This underscores that shared genetics across traits does not necessarily mean shared biology. - Source: PubMed
Gong ChenDand NickButler Amy WAmar AriellaLiu LuTriantafyllou Pinelopi MariaMorris David LVyse Timothy J - To synthesize the genetic architecture of primary open-angle glaucoma (POAG) across the full variant spectrum and map each genetic subtype to its clinical phenotype, IOP profile, optic nerve morphology, systemic associations, and treatment response. - Source: PubMed
Publication date: 2026/09/12
Abu-Amero Khaled KAbualkhair ShereenAlOtaibi HajarSesma Gorka - Major depressive disorder (MDD) is associated with multiple pathophysiological mechanisms, including dysregulation of monoaminergic systems, excessive glutamatergic activity, reduced neurotrophic support, inflammation, and oxidative stress. The combination of dextromethorphan, an N-methyl-D-aspartate (NMDA) receptor antagonist and sigma-1 receptor agonist, with bupropion, a dopamine/norepinephrine reuptake inhibitor, has been reported to exert rapid antidepressant effects. In the present study, we evaluated the therapeutic effects of the dextromethorphan-bupropion combination on behavioral outcomes and neurotransmitter, inflammatory, and apoptotic pathways in a mouse model of MDD. - Source: PubMed
Publication date: 2026/08/19
Buran Kavuran İlayÖnalan EbruTürk Zeliha İremEröksüz Hatice - Stroke is a major complication of atrial fibrillation (AF), and risk prediction using the congestive heart failure, hypertension, age, diabetes, stroke, vascular disease, and sex category score (CHA₂DS₂-VASc) remains limited by residual heterogeneity. We aimed to identify plasma proteins associated with post-AF stroke and evaluate whether a protein score provides incremental predictive information beyond CHA₂DS₂-VASc. - Source: PubMed
Publication date: 2026/07/23
Huang ShengkangFeng XinWu HuilinLiang RongxuanGao YuanWang ZhaojunTang BotaoWu JiatongFang JunkaiYang ZiangTiemuerniyazi XierailiLin JianchengDuan YijingxuanXu WenruMao HuaZhao WeiHu ZhanDuan ChuanzhiFeng Wei - This study aims to investigate the role of neurotrophin-4 (NTF4) in gestational diabetes mellitus (GDM) and to elucidate the underlying mechanism by which NTF4 regulates high glucose-induced apoptosis and inflammation in HTR-8/SVneo cells via the PI3K/AKT signaling pathway. - Source: PubMed
Zhang LiYang Juan