Ask about this productRelated genes to: NTF3 antibody
- Gene:
- NTF3 NIH gene
- Name:
- neurotrophin 3
- Previous symbol:
- -
- Synonyms:
- NGF2
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1991-01-15
- Date modifiied:
- 2016-10-05
Related products to: NTF3 antibody
Related articles to: NTF3 antibody
- - Source: PubMed
Publication date: 2026/10/03
Duong Manh DatKim Soo-AAhn Sang-Gun - Taste dysfunction is commonly associated with aging and accompanied by morphological and molecular alterations in the tongue epithelium. To investigate the mechanisms underlying this phenomenon, we utilized Klotho-deficient (Kl -/-) mice, a model of accelerated aging. The tongue epithelium of Kl -/- mice showed altered muscle organization and increased clear spaces within the muscle compartment. The minor salivary glands displayed acinar cell atrophy. Notably, compared with WT, Kl -/- mice presented a reduced taste bud diameter and decreased expression of key taste receptors, as well as type II taste cells. Importantly, immunohistochemical and western blot analyses revealed decreased expression of SOX2 in taste buds and tongue epithelium. Overexpression of SOX2 significantly upregulated PLCB2, which plays roles in taste bud cell differentiation and function. Conversely, siRNA-mediated knockdown of SOX2 resulted in reduced expression of taste-related genes (Keratin 8, PLCB2, Taste receptors) and decreased expression of NTF3 and BDNF, neurotrophic factors involved in sensory-neural maintenance. Furthermore, SOX2 directly regulated the promoter activity of NTF3, suggesting that SOX2 contributes to taste bud maintenance through transcriptional regulation of NTF3. Together, these findings suggest that altered SOX2 expression is associated with changes in taste-associated proteins and neurotrophic-factors expression in the aging Kl -/- tongue. - Source: PubMed
Publication date: 2026/09/24
Duong Manh DatKim Soo-AAhn Sang-Gun - Tiger nut ( L.), a highly promising oil crop, produces oil rich in unsaturated fatty acids and contains various natural bioactive components. However, the role of these accompanying lipid constituents in the health effects of tiger nut oil has been insufficiently investigated. In this study, tiger nut oil unsaponifiables (TNU) were prepared saponification followed by solvent extraction, and their chemical composition was identified by GC-MS. The effects of TNU on metabolic dysregulation and cognitive impairment were assessed in a high-fat diet (HFD)-induced obese mouse model. The refined tiger nut oil was found to contain 1.247 ± 0.021% unsaponifiable matter, with phytosterols, tocopherols, and squalene as the major constituents. TNU supplementation resulted in significant attenuation of HFD-induced weight gain and lipid accumulation, improvement in glucose homeostasis and insulin sensitivity, and reduction in hepatic lipid deposition and adipose tissue pathology. Moreover, the hepatic expression of lipogenic genes , , and was markedly downregulated by TNU. In parallel, TNU effectively rescued learning and memory deficits and spatial cognitive impairment in obese mice, suppressed aberrant microglial activation in the hippocampus, alleviated neuroinflammation, and upregulated the mRNA expression of the synaptic protein as well as the neurotrophic factors , , and . In summary, TNU may ameliorate HFD-induced cognitive dysfunction by modulating disorders of glucose and lipid homeostasis and inhibiting the metabolic inflammation-neuroinflammation axis. This study contributes to a theoretical basis for the development of tiger nut oil as a functional dietary lipid resource. - Source: PubMed
Publication date: 2026/10/05
Chen RonghuiLiu ChenghaoLi XiangLi SijingTong ZhirongHu MaolinLi ZhiqiangXu ChengjuWang ZijianLiu XiaoyingWang Yutang - This study reports, for the first time, the establishment of endometrial organoids (EOs) from the Arabian camel (Camelus dromedarius) and evaluates their suitability as an in vitro model for embryo-maternal interactions during implantation. Endometrial tissues were collected from non-pregnant she-camels and cultured in Matrigel with a defined growth medium. By Day 7, organoids displayed a spherical morphology (200-250 µm), remained viable for up to 20 days, and expanded to approximately 1 mm. They exhibited epithelial characteristics and high proliferative activity, confirmed by expression of mucin-1, pan-cytokeratin, vimentin, and Ki67. Day 7 in vitro-produced embryos co-cultured with EOs showed significant improvements in development and trophoblast outgrowth. This was accompanied by upregulation of key developmental genes (OCT4, c-MYC, KLF4, CDX2). Cytokine profiling revealed enhanced bidirectional signaling: embryos increased secretion of CCL2, CCL4, IGF-1, IFNG, IL1α, IL12b, IL-8, LIF, IL-10, and NTF3, while EOs upregulated VEGFA, IL-8, CCL2, and TIMP1. Co-culture uniquely induced additional cytokines and amplified signaling intensity. Metabolomic analysis of embryo-conditioned medium identified 108 metabolites, including steroids associated with immunomodulation. Notably, embryos cultured in EO-conditioned medium developed up to Day 21 post-cleavage, reaching a mean diameter of 2.4 mm. Overall, camel EOs provide a physiologically relevant platform that supports embryo development and enables detailed investigation of cytokine-mediated embryo-maternal communication and implantation processes in the dromedary camel. - Source: PubMed
Publication date: 2026/09/02
Saadeldin Islam MAlqassem AlanoudAlomzyan SheemaAlmalki Reem HShinwari ZakiaHama AdelInal SahikaAbdelazim Aaser MAlaiya AyodeleRahman Anas M AbdelAwartani Khalid - Major depressive disorder (MDD) is associated with multiple pathophysiological mechanisms, including dysregulation of monoaminergic systems, excessive glutamatergic activity, reduced neurotrophic support, inflammation, and oxidative stress. The combination of dextromethorphan, an N-methyl-D-aspartate (NMDA) receptor antagonist and sigma-1 receptor agonist, with bupropion, a dopamine/norepinephrine reuptake inhibitor, has been reported to exert rapid antidepressant effects. In the present study, we evaluated the therapeutic effects of the dextromethorphan-bupropion combination on behavioral outcomes and neurotransmitter, inflammatory, and apoptotic pathways in a mouse model of MDD. - Source: PubMed
Publication date: 2026/08/19
Buran Kavuran İlayÖnalan EbruTürk Zeliha İremEröksüz Hatice