Ask about this productRelated genes to: NPAS1 antibody
- Gene:
- NPAS1 NIH gene
- Name:
- neuronal PAS domain protein 1
- Previous symbol:
- -
- Synonyms:
- MOP5, PASD5, bHLHe11
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 1998-05-29
- Date modifiied:
- 2016-01-15
Related products to: NPAS1 antibody
Related articles to: NPAS1 antibody
- Although IFI44 is recognized for its crucial role in autoimmune disorders, its function in breast cancer (BC) remains unclear. This study aimed to investigate the immune-related and prognostic significance of IFI44 in BC. - Source: PubMed
Publication date: 2026/04/08
Wu JiahuiYi WangLiu MengtingLi YingliangZhou BoxuanWu ZiyunCao WeiShi QingfengCai XiangkaiXiong Haiwei - Exploration allows animals to gather information and adapt to changing conditions. Yet, it also exposes them to potential threats, requiring neural systems that weigh uncertainty and regulate behavioral transitions between cautious and exploratory states. These computations are distributed across cortical and subcortical networks, including the basal ganglia, which integrate sensory, motivational, and contextual information to shape action-selection behaviors. Within this circuitry, the globus pallidus externa (GPe) occupies a central but underappreciated role. Once viewed as a relay between striatum and downstream nuclei, the GPe is gaining recognition as a dynamic regulator that integrates diverse inputs and exerts bidirectional control over motor and cognitive processes. Here, we examine arkypallidal NPAS1-expressing GPe (GPe) neurons, which form preferential inhibitory projections to the striatal matrix. Chemogenetic manipulations and calcium measurement reveal that GPe activity modulates and encodes risk-taking behavior sequences, identifying a circuit mechanism by which the GPe can regulate adaptive decision-making in risky contexts. - Source: PubMed
Publication date: 2026/03/23
Haggerty David LSorigotto Beatriz DSalinas Armando GLovinger David MAbrahao Karina P - Neuronal PAS domain protein 1 (NPAS1) is a protein-coding gene expressed mainly in the central nervous system and plays a key role in nervous system development. The expression and prognostic value of NPAS1 in colorectal adenocarcinoma (COAD) are unknown. - Source: PubMed
Publication date: 2026/02/24
Bai MiaoyuHu KeyiCui JitaoXia QingqingLi JieWang WenweiLiu BinghuiZhu XudongYe Qigang - The bHLH-PAS protein family consists of transcription factors that are involved in the regulation of key physiological processes such as the response to hypoxia, circadian rhythms, the detoxification of xenobiotics, and metabolic homeostasis. These proteins act as environmental sensors, integrating diverse signals into transcriptional responses. In recent years, increasing attention has been paid to their role in regulating endoplasmic reticulum stress (ER stress), which is an adaptive cellular response to disturbances in protein-folding. Prolonged or severe ER stress can activate the unfolded protein response (UPR) and apoptotic pathways, contributing to the development of numerous disorders, including neurodegenerative, cancerous, and inflammatory diseases. This review focuses on the functions of bHLH-PAS proteins, such as AHR, HIF, SIM, NPAS1-4, and CLOCK, with particular emphasis on their potential role in modulating ER stress. Molecular mechanisms through which these proteins regulate responses to hypoxia and other cellular stressors are also discussed, with a focus on their importance in maintaining homeostasis and their potential as therapeutic targets. - Source: PubMed
Publication date: 2025/12/12
Krauze IzabelaKrzystek-Korpacka MałgorzataMaciejewska KamilaGreb-Markiewicz Beata - Perineural invasion (PNI) is an important pathologic feature of cervical cancer that is associated with poor prognosis and provides key information for clinical decisions. A better understanding of the molecular mechanisms underlying PNI could lead to improved patient treatment strategies. Here, we generated whole-exome, whole-genome, and RNA sequencing data from tumors and matched normal clinical samples of 45 patients with cervical cancer and performed a comparative analysis between 23 PNI and 22 non-PNI tumors. A robust machine learning approach identified a three-gene expression signature of MT1G, NPAS1, and SPRY1 that could predict the tumor PNI status with high accuracy, which was validated using an independent cohort (18 PNI and 19 non-PNI). Loss-of-function FBXW7 mutations were identified as driver events for PNI that lead to increased MYC activity and an immunosuppressive tumor microenvironment. Finally, a deep learning model for predicting drug efficacy over patients' transcriptomic data revealed OTX015, a BET inhibitor, as a promising treatment that targets mutated FBXW7 PNI tumors. This study provides a rich resource for elucidating the molecular mechanisms of PNI tumors, laying a critical foundation for developing effective diagnostic and therapeutic strategies for PNI tumors in cervical cancer. - Source: PubMed
Wan TingDeng TingPeng XinxinCai GuangyaoHuang HeLing YihongGao ShangbingLi HongyueYu DanyangLi HaonanZhao YiningLiang HanLiu Jihong