Ask about this productRelated genes to: MYO9B antibody
- Gene:
- MYO9B NIH gene
- Name:
- myosin IXB
- Previous symbol:
- CELIAC4
- Synonyms:
- -
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-04
- Date modifiied:
- 2015-09-04
Related products to: MYO9B antibody
Related articles to: MYO9B antibody
- Cervical cancer, a public health concern in low-income countries has high mortality in women. miR-4687-3p was downregulated in cervical cancer patients of South Indian region. MicroRNAs are known to alter gene expression in cancers, and the function of miR-4687-3p in cervical cancer is not known. - Source: PubMed
Publication date: 2026/06/30
Himal IrisS KannanG S Anisha - Clear cell renal cell carcinoma (ccRCC) exhibits extensive immune infiltration, yet the influence of immunological heterogeneity on clinical outcomes remains poorly elucidated. - Source: PubMed
Publication date: 2026/06/21
Chen YuanhongGuo ChunHuang ShaoangLing CaixiaLin WenxianLiang ZhengfangZhao JingjieMeng LingzhangTang YulianYe Kun - Peri-implantitis (PI) exhibits worse symptoms and prognosis than periodontitis (PD), yet their molecular differences remain unclear. This study aimed to identify these distinctions to clarify their unique pathogeneses. - Source: PubMed
Publication date: 2026/03/28
Wang YanLi NaGuo TaoLiu JingYu YingTang RuiqiHuang Xu - Myosin IXb (Myo9b) is a single-headed motor protein in the myosin superfamily. It contains a unique Rho guanosine triphosphatase-activating protein domain, which enables it to regulate cytoskeletal dynamics and cell migration. Most studies on Myo9b are focused on epithelial repair, intestinal barrier function, and immune cell motility; however, its roles in immune regulation, inflammatory responses, tumorigenesis, and various autoimmune diseases have garnered notable attention in recent years. This study comprehensively reviews the structural characteristics, regulatory mechanisms, and biological functions of Myo9b, along with emphasizing its crucial roles in various pathological conditions and its potential as a therapeutic target. - Source: PubMed
Publication date: 2026/02/06
Dong ShufengWang KaiYi Feng-ShuangHu YongleiZhang Xin - The ability of the immune system to control malignant tumors depends in part on the migratory ability of CD8 T cells. Developing in-depth cellular and molecular understanding into how changes in the structural organization of collagen-IV differentially governs site-specific CD8 T-cell migration through restrictive tissue barriers is challenging given the dynamic biomechanical alterations occurring in the basement membranes of tumor blood vessels. Thus, uncovering new mechanisms regulating CD8 T-cell migration through structurally altered or denatured collagen-IV may allow the development of clinically useful strategies to selectively enhance immune cell infiltration of tumors in a context-dependent manner. This work provides evidence that a secreted RGDKGE-containing collagen peptide limits CD8 T-cell migration on denatured forms of collagen-IV, but not on normal triple helical collagen-IV by a unique mechanism. This novel pathway involves the context-dependent regulation of myosin IXB (MYO9B) and Yes-associated protein-1 (YAP) in CD8 T cells, ultimately leading to altered F-actin polarization and selectively reduced migration on denatured collagen-IV that is enriched in basement membranes of tumor vessels. In addition to defining a previously unknown mechanism that contributes to the site-specific control of CD8 T-cell migration, these studies provide a strategy to selectively reverse the inhibitory effects of this endogenously secreted collagen peptide using a function-blocking antibody, resulting in enhanced accumulation of CD8 T cells in tumors growing in vivo. - Source: PubMed
Han XiangHuaCaron Jennifer MBrooks Peter C