Ask about this productRelated genes to: MYO16 antibody
- Gene:
- MYO16 NIH gene
- Name:
- myosin XVI
- Previous symbol:
- -
- Synonyms:
- MYR8, KIAA0865, Myo16b, NYAP3, PPP1R107
- Chromosome:
- 13q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-02-12
- Date modifiied:
- 2014-11-19
Related products to: MYO16 antibody
Related articles to: MYO16 antibody
- The Chinese mitten crab (Eriocheir sinensis) undergoes periodic molting and exhibits discontinuous muscle growth during its larval metamorphosis, yet the underlying molecular drivers remain poorly understood. Myosin, a central motor protein, is crucial for muscle function and diverse cellular processes. - Source: PubMed
Publication date: 2026/06/18
Wu HaiyueChen SisiAn XinyaoPang AoboHu XianSun JinqiuYin ChijieYang WenqiSun XiaoliZhang HuabinDing GeWang GangZhang Daizhen - Computer-assisted sperm analysis was conducted to phenotypically and genetically assess the sperm motility traits of Jinding drakes. The phenotypic evaluation revealed moderate variability across motility parameters, consistent with a polygenic inheritance pattern. Correlation analysis further demonstrated strong associations among velocity-related traits and inverse relationships between linearity and lateral head displacement metrics. Genome-wide association studies identified 15 significant single-nucleotide polymorphisms (SNPs) associated with five key sperm motility traits (straight-line velocity, curvilinear velocity, average path velocity, amplitude of lateral head displacement, and mean angular displacement) at a genome-wide threshold of < 1 × 10. Notably, of these 15 SNPs, nine were concentrated on chromosome 1, indicating the presence of a genomic hotspot for regulation of sperm motility. Pleiotropic effects were evident, as several SNPs were found to influence multiple motility traits. Candidate genes implicated in essential sperm functions included (cytoskeletal dynamics), (flagellar structure), and (epigenetic regulation during spermatogenesis), as well as genes involved in membrane integrity, mitochondrial function, and immune regulation. These findings provide novel insights into the genetic architecture underlying sperm motility of Jinding drakes and establish a basis for molecular breeding strategies to enhance reproductive efficiency of waterfowl. - Source: PubMed
Publication date: 2026/06/01
Zhu ChunhongGu HaotianWang ZhichengSong WeitaoTao ZhiyunZhang ShuangjieChen LiLi HuifangLiu Hongxiang - Enhancing disease resistance is one of the primary objectives of the poultry industry through breeding. The heterophil to lymphocyte ratio (H/L ratio) represents a critical indicator of stress and immune status in chickens. However, the essential genetic networks and functional genes governing the H/L ratio remain uncharacterized. In this study, by combining genomic and transcriptomic data, we aimed to identify functional variants and key genes regulating the H/L ratio in white-feathered broilers. Using a genome-wide association study (GWAS) analysis of 218 birds, we identified single-nucleotide polymorphisms (SNPs) significantly associated with H/L ratio and H count, respectively. These SNPs were annotated to several candidate genes, including MYO16, AKT3, RBM34, SMOC2, and TOMM20. Functional enrichment analysis revealed that candidate genes were involved in FoxO signalling pathway, mTOR signalling pathway, and other immune-related pathways. Fine-mapping analysis identified potential causal variants at multiple sites, specifically chr1:138395826, chr3:34663003, chr3:34663053, and chr3:34663073. Additionally, through integrating transcriptomic and immune-related phenotypic data using weighted gene co-expression network analysis, key hub genes were identified in the bursa and thymus, respectively. Moreover, combined analysis of candidate and hub genes from the GWAS and transcriptomic analyses, respectively, illustrated that these genes were co-enriched in functionally important pathways, including mTOR, FoxO, and MAPK signaling pathways. In summary, our results indicated that MYO16 and AKT3 may represent potential causal genes associated with H/L ratio, and that multiple immune signaling pathways regulate the balance between heterophil and lymphocyte immune cells in chickens. These findings provide new insights into the genetic architecture of immune-related traits in poultry. Moreover, it is crucial to confirm the biological function of these candidate genes and variants by conducting further verification in larger populations with genetic diversity. - Source: PubMed
Publication date: 2026/01/08
Zheng JumeiWang QiaoO'Grady John FWang ZixuanDeng ManZhang JinLi XiangZhu YuqingMacHugh David EZhao Guiping - Preterm infants are at risk for bilirubin-induced brain injury. Phototherapy is effective for lowering serum bilirubin but has potential adverse effects. The independent effects of hyperbilirubinemia and phototherapy on the hippocampal gene expression profile were determined using a preterm-equivalent Gunn rat model. - Source: PubMed
Publication date: 2025/12/22
Satrom Katherine MLock Eric FLund Troy CTran Phu VRao Raghavendra B - Chronic obstructive pulmonary disease (COPD) and asthma are common and serious respiratory diseases worldwide. Their clinical overlap and lack of specificity in current biomarkers pose a great diagnostic challenge for early diagnosis. To address this gap, this study aimed to identify common transcriptomic features and potential diagnostic biomarkers for the diseases using an integrated bioinformatics approach. This study analyzed COPD chip data using weighted gene co-expression network analysis, identifying 375 key differential genes. Functional enrichment analysis was performed to assess the biological roles of these genes. Machine learning methods, including least absolute shrinkage and selection operator and random forest, were employed to identify 5 key biomarkers: MYO16, CHML, POLR3B, ZNF101, and ZNF143. The findings revealed that the identified genes were primarily associated with immune response and T cell-related inflammatory pathways. Among the biomarkers, ZNF143 was significantly upregulated in both COPD and asthma, with expression levels notably higher in COPD patients compared to asthma patients. Expression analysis and receiver operating characteristic curve assessment validated ZNF143 as a potential diagnostic biomarker. Additionally, the CIBERSORT algorithm was used to evaluate immune cell infiltration, revealing a positive correlation between ZNF143 and CD8 T cells, M2 macrophages, and γ-δ T cells, and a negative correlation with memory-activated CD4 T cells, plasma cells, and neutrophils. These findings suggest a potential role for ZNF143 in both COPD and asthma, supporting its candidacy as an early diagnostic biomarker. This research offers preliminary insights into the molecular mechanisms underlying these respiratory diseases and may inform future directions for diagnostic and therapeutic exploration. - Source: PubMed
Yang TianyiLi QiangJin GuannanDu SonghaoYu YangJiang Baihua