Ask about this productRelated genes to: MYLIP antibody
- Gene:
- MYLIP NIH gene
- Name:
- myosin regulatory light chain interacting protein
- Previous symbol:
- -
- Synonyms:
- MIR, IDOL
- Chromosome:
- 6p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-26
- Date modifiied:
- 2015-08-25
Related products to: MYLIP antibody
Related articles to: MYLIP antibody
- Endothelial dysfunction profoundly compromises the barrier function that precludes trans-endothelial entry of low-density lipoprotein cholesterol (LDL-C) into the vessel wall. LDL-C retention in the vessel wall is atherogenic and its flux involves several mechanisms including LDL-receptor (LDL-R) mediated transcytosis, a process that is facilitated by inflammatory stressors. In this study, we aimed to investigate the role of interleukin-6 (IL-6) in regulating LDL-R and LDL-C uptake by vascular endothelial cells. - Source: PubMed
Publication date: 2026/04/25
Zegeye Mulugeta MVeettil Jishamol TParamel Geena VKurt SetaSalihovic SamiraLjungberg Liza UKumawat Ashok KSirsjö Allan - Impact of pre-treatment platelet-monocyte ratio on prognosis in patients with non-small cell lung cancer. 2. Screening and analyzing the relationship between NSCLC, platelet- and monocyte-associated genes and prognosis. 3. Expression of platelet- and monocyte-associated genes in NSCLC and the correlation between them and clinicopathological features and survival time. - Source: PubMed
Publication date: 2026/04/06
Tang YonglianHuang YiliChen LeiHuang ZiguiHuang XiaoliangHe Zhiyi - Uterine corpus endometrial carcinoma (UCEC) is a common gynecologic malignancy characterized by metabolic reprogramming and immune dysregulation. This study aimed to investigate the prognostic and diagnostic value of lipid metabolism- and oxidative stress-related genes (LMOSGs) in UCEC. - Source: PubMed
Publication date: 2026/04/06
Li HongfengBian JiaZhang QinweiDu QiaoWang YijieShang YapingLi Xuehe - Cytochrome P450, family 7, subfamily b, polypeptide 1 (CYP7B1) is a widely expressed enzyme involved in the hydroxylation of sterols. Generated by transposon technology in zygotes, male rats lacking expression in homozygosis showed an absence of mRNA expression in the liver, small intestine, adipose tissue, and muscle. Elevated levels of 25-hydroxycholesterol were found in the liver of mutant rats. After overnight fasting, plasma triglyceride (TG) levels were increased in the homozygous rats. In agreement with this, increased hepatic secretion of very-low-density lipoprotein-TG (VLDL) in fasting rats treated with tyloxapol and decreased low-density receptor protein (LDLr) on the hepatocyte plasma membranes were observed. The decrease in LDLr was not due to decreased mRNA expression but to increased expressions of its proteases ( and ). RNA sequencing identified , , and as targets of the absence. However, the hepatic protein contents of IGFBP2 were increased in -deficient rats, accompanied by a normal glucose tolerance test. HepG2 cells lacking showed increased expressions of and . These results suggest a role of CYP7B1 in the control of hepatic IGFBP2 and VLDL-TG secretion as a prediabetes sign exerted through 25-hydroxycholesterol and transcriptional or translational mechanisms depending on the species. - Source: PubMed
Publication date: 2025/12/12
Martínez-Beamonte RobertoGuillén NataliaSánchez-Marco JavierHerrera-Marcos Luis VSurra Joaquín CNavarro María ABarranquero CristinaArnal CarmenPuente Juan JRodríguez-Yoldi Ma JesúsMendiara IsabelDomeño CeliaNerín CristinaGeurts Aron MOsada JesúsLaclaustra Martín - Overexpression of the low-density lipoprotein receptor (LDLR) is known to decrease apolipoprotein E (APOE) levels and alleviate amyloid beta (Aβ) pathology. We hypothesized that inhibiting the Inducible Degrader of LDLR (IDOL), an enzyme that ubiquitinates LDLR for degradation, would increase endogenous LDLR levels and attenuate amyloid pathology. - Source: PubMed
Karahan HandeHartigan KellyAl-Amin Md MamunJohn Sutha KMcCord BrianneWijeratne H R SagaraAcri Dominic JSmith Daniel CDabin Luke CCordero Hannah M RondonKim ByungwookLee Do-HunKim Jungsu