Ask about this productRelated genes to: MYCN antibody
- Gene:
- MYCN NIH gene
- Name:
- MYCN proto-oncogene, bHLH transcription factor
- Previous symbol:
- NMYC
- Synonyms:
- bHLHe37, N-myc, MYCNOT
- Chromosome:
- 2p24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2017-02-27
- Gene:
- MYCNOS NIH gene
- Name:
- MYCN opposite strand
- Previous symbol:
- -
- Synonyms:
- NCYM, N-CYM, MYCN-AS1
- Chromosome:
- 2p24.3
- Locus Type:
- unknown
- Date approved:
- 2004-02-04
- Date modifiied:
- 2019-03-06
- Gene:
- MYCNUT NIH gene
- Name:
- MYCN upstream transcript
- Previous symbol:
- MYCNUN
- Synonyms:
- lncUSMycN
- Chromosome:
- 2p24.3
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2013-08-14
- Date modifiied:
- 2018-07-26
Related products to: MYCN antibody
Related articles to: MYCN antibody
- The human placenta sustains pregnancy through intricate trophoblast lineage dynamics that are critical for fetal development and pregnancy success. While studies on protein-coding genes (PCGs) have advanced our understanding of placental biology, the regulatory roles of noncoding RNAs, particularly long noncoding RNAs (lncRNAs), in trophoblast lineage specification and function remain poorly understood. Here, we profile single-cell lncRNA dynamics across human placental development, revealing distinct cell-type- and gestational stage-specific expression profiles. Integrated analysis revealed that lncRNAs modulate histone modification levels at the regulatory regions of target genes via -action, thereby regulating the expression of key genes essential for trophoblast differentiation. Functional studies by using and models fully identify --, and /- as pivotal regulatory axes driving cytotrophoblast self-renewal, syncytiotrophoblast fusion, and epithelial-mesenchymal transition, respectively, which are essential for trophoblast identity and function. Notably, dysregulation of lncRNA-PCG pairs in pathological pregnancies underscores the clinical relevance of these noncoding networks. Together, our findings uncover an unappreciated layer of lineage-specific noncoding regulation, providing mechanistic insight and potential biomarkers for placental development and associated disorders. - Source: PubMed
Publication date: 2026/04/17
Zhang WeiyiLe ChunyanYi ShanruLiu WenqiangLiu XiaoyuYin ZhenWang HongGao RuiGao ShaorongChen Jiayu - Interstitial deletions of the distal short arm of chromosome 2 including MYCN have only been reported for a small number of individuals. Germline deletions and mutations of MYCN cause Feingold syndrome 1 (FS1), a rare disorder characterized by microcephaly, digit anomalies, gastrointestinal atresias, short stature, dysmorphic features, and intellectual disability. We present a series of six individuals referred for SNP microarray with overlapping deletions of 2p ranging from 3.4 to 16.8 Mb in size, with a common overlapping region of 1.53 Mb spanning (14,614,477-16,148,021) [hg19] and including five genes: NBAS, DDX1, MYCNUT, MYCNOS, and MYCN. Clinical information was available for five individuals. Clinical features included core features of FS1 such as microcephaly, digit anomalies, and gastrointestinal atresias as well as structural cardiac defects, hearing loss, and renal anomalies, which are features less consistently associated with FS1. Other features observed in several individuals, that have not specifically been associated with FS1 were motor delay, structural brain abnormalities, genital abnormalities, and radioulnar synostosis. These results indicate that while individuals with deletions of 2p spanning several megabases and including MYCN can present with features not typically associated with FS1, the common core features are usually present. - Source: PubMed
Publication date: 2018/08/08
Burnside Rachel DMolinari SharonBotti ChristinaBrooks Susan SklowerChung Wendy KMehta LakshmiSchwartz StuartPapenhausen Peter