Ask about this productRelated genes to: MS4A6A antibody
- Gene:
- MS4A6A NIH gene
- Name:
- membrane spanning 4-domains A6A
- Previous symbol:
- MS4A6
- Synonyms:
- CD20L3
- Chromosome:
- 11q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-12-08
- Date modifiied:
- 2016-10-05
Related products to: MS4A6A antibody
Related articles to: MS4A6A antibody
- Cerebrospinal fluid amyloid beta 42, total tau, and phosphorylated tau 181 are well accepted markers of Alzheimer's disease. These biomarkers better reflect disease pathogenesis compared to clinical diagnosis. Here, we perform a genome wide association study meta-analysis including 18,948 individuals of European ancestry and identify 12 genome-wide significant loci across all three biomarkers, eight of them novel. We replicate the association of biomarkers with APOE, CR1, GMNC/CCDC50 and C16orf95/MAP1LC3B. Novel loci include BIN1 for amyloid beta and GNA12, MS4A6A, SLCO1A2 with both total tau and phosphorylated tau 181, as well as additional loci on chr. 8, near ANGPT1 and chr. 9 near SMARCA2. We also demonstrate that these variants have significant association with Alzheimer's disease risk, disease progression and/or brain amyloidosis. The associated genes are implicated in lipid metabolism independent of APOE, coupled with autophagy and brain volume regulation driven by total tau and phosphorylated tau 181 dysregulation. - Source: PubMed
Publication date: 2026/04/21
Timsina JigyashaJiang ChenyangMcCartney Daniel LTao FeifeiDalmasso Maria CarolinaNajar JennaAnastasi FedericaOhlei OlenaPuerta Fuentes RaquelYang ChenyuBradley JosephWestern DanielAli MuhammadWang CiyangYang ChengranWu YingLiu MenghanBudde JohnWilliams JulieMahoney RebeccaCastillo Morales AtahualpaHohman Timothy JDumitrescu LoganWang Ting-ChenTesi Niccolo'Kern SilkeWaern MargdaSkoog Ingmarvan Harten ArgondePijnenburg Yolande A Lvan der Flier Wiesje MSánchez-Juan PascualRodriguez-Rodriguez EloyKleineidam LucaPeters OliverSchneider AnjaKüçükali FahriBellenguez CélineGrenier-Boley BenjaminHeikkinen Samide Rojas ItziarRujescu DanScherbaum NorbertHausner LucreziaDüzel EmrahGrimmer TimoWiltfang JensVandenberghe RikEngelborghs SebastiaanHeilmann-Heimbach StefanieSchmid MatthiasTegos ThomasScarmeas NikolaosDols-Icardo OriolMoreno FerminPérez-Tur JordiBullido María JSánchez-Valle RaquelÁlvarez VictoriaGarcía-González PabloMir PabloReal Luis MPiñol-Ripoll GerardGarcía-Alberca Jose MaríaSeelaar HarroRamakers InezPapma JanneHulsman MarcLaske ChristophTeipel StefanPriller JosefPerneczky RobertBuerger KatharinaNöthen Markus MLewczuk PiotrKornhuber JohannesHampel HaraldGiegling InaGoldhardt OliverDiehl-Schmid JanineAndrade VictorHeneka Michael MtFrölich LutzVogelgsang JonathanGraff CarolineThonberg HakanUllgren AbbePapenberg GoranDeleuze Jean-FrançoisDufouil CaroleWagner MichaelJessen FrankHolstege Hennevan Duijn CorneliaLebouvier ThibaudHannon OlivierLeinonen VilleSoininen HilkkaHerukka Sanna-KaisaGiedraitis VilmantasLöwenmark MalinKilander LenaGenius PatriciaRodríguez BlancaLuckett Emma SNavarro ArcadiCano AmandaMarquié MartaBlennow KajZetterberg HenrikLleo AlbertoBoada MercèRuiz AgustinLee Virginia Man-YeeVan Deerlin Vivianna MDeming YuetivaJohnson Sterling CEngelman Corinne DPastor PauAlvarez IgnacioPeskind Elaine RHeslegrave Amanda JSaykin Andrew JNho KwangsikSchindler Suzanne EMorris John CHoltzman David MMcDade EricRenton Alan EGoate AlisonIbanez LauraRiemenschneider MatthiasAlbert Marilyn SLaws Simon MPorter TenielleO'Brien Eleanor KShaw Leslie MTijms Betty MIngelsson MartinVisser Pieter JelleHiltunen MikkoSleegers KristelRitchie Craig WSims RebeccaBelloy MichaelLambert Jean-CharlesVilor-Tejedor NataliaFernández Maria VictoriaLi Qingqin SNagle Michael WMarioni Riccardo ERamirez AlfredoBertram Larsvan der Lee Sven JCruchaga Carlos - Breast and prostate cancers are both hormone-driven adenocarcinomas that undergo analogous invasion programs. Using lightsheet microscopy on intact tumors, we identified transitional junctions between precancerous and invasive regions. We then developed a multimodal serial-section workflow integrating volumetric reconstruction with spatial transcriptomics. Analysis of 319 spatial assays from 51 cases revealed gene-expression features and novel structural insights defining the shift from precancer to invasive disease. In breast cancer, loss of MGP and PLAT was associated with invasive transition and promoted tumorigenesis in functional assays. In prostate cancer, GDF15, ALDH1A3, ANPEP, and FASN were upregulated along invasive progression, and their knockdown in PC-3 cells suppressed proliferation and migration. Enrichment of tumor-associated macrophages (SPP1⁺, MS4A6A⁺) along non-TNBC breast cancer transitions highlights immune involvement as a potential driver of invasiveness. - Source: PubMed
Publication date: 2026/04/17
Storrs ErikMo Chia-KueiChou Wen-HungBhatt GauravChen SiqiWei XiyiHouston AndrewKarpova AllaJayasinghe Reyka GLal PreetBayguinov PeterHerndon John MLi XiangAnjum Simin FariaFang XiangweiWendl Michael CLiu XinhaoZheng HongyuDavies Sherri RWang Julia TShinkle AndrewFulton Robert SPonce JenniferHeinz MichaelHead RichardChen DeZhao YutingFenyo DavidLi Yang EMa Cynthia XAft RebeccaReimers Melissa AKim Albert HPuram Sidharth VFitzpatrick James A JShoghi Kooresh IFigenshau R SherburneAdemuyiwa Foluso OJu TaoColditz Graham ADrake Bettina FPatti Gary JOh Stephen TKim Eric HGillanders William EOlson John AChheda Milan GWeimholt CodyVeis Deborah JRaphael Benjamin JFields Ryan CPachynski Russell KChen FengDing Li - Hepatocellular carcinoma (HCC) is characterized by its insidious onset and rapid progression. Investigating diagnostic and therapeutic strategies targeting programmed cell death (PCD) represents a promising research direction. - Source: PubMed
Publication date: 2026/03/06
Lei LixingLiu NianTang LinglingLiu QianqianPan KeHuang Xiaohua - Transcriptome-wide association studies (TWAS) have successfully identified genes associated with complex traits and diseases, but most have been performed using bulk gene expression data, which aggregate signals across heterogeneous cell types. Population-scale single-cell RNA sequencing data now make it possible to perform TWAS at the cell-type resolution, but present unique challenges due to strong noises, technical variations, and high sparsity. Here, we propose scTWAS, a statistical method to conduct cell-type-specific TWAS using single-cell data. Leveraging a latent-variable model and moment-based estimation to address the challenges of single-cell data, scTWAS consistently improves the prediction of genetically regulated gene expression across cell types in both blood and brain tissues. Compared to existing methods, scTWAS identifies substantially more gene-trait associations across 29 hematological traits and three immune-related diseases in immune cell types. An application to Alzheimer's disease also reveals cell-subtype-specific associations, including MS4A6A in the disease-associated microglial subtype and PPP1R37 in the inflammatory microglial subtype. - Source: PubMed
Publication date: 2026/03/12
Lin ZhaotongSu Chang - MS4A4A and MS4A6A are microglia-expressed genes linked to Alzheimer's disease risk. In this issue of Neuron, Rosner et al. show that these proteins cooperatively restrain TREM2 signaling, dampening protective microglial responses and highlighting MS4A inhibition as a potential strategy to rejuvenate the brain's innate immune system in Alzheimer's disease. - Source: PubMed
Hansen David VKarch Celeste MMainali DrishyaPiccio Laura