Ask about this productRelated genes to: MRPS11 antibody
- Gene:
- MRPS11 NIH gene
- Name:
- mitochondrial ribosomal protein S11
- Previous symbol:
- -
- Synonyms:
- FLJ23406, HCC-2, FLJ22512
- Chromosome:
- 15q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-28
- Date modifiied:
- 2016-10-05
Related products to: MRPS11 antibody
Related articles to: MRPS11 antibody
- Osteoarthritis (OA) progression involves chronic inflammation, chondrocyte senescence, and extracellular matrix (ECM) degradation affecting all synovial joint tissues. To date, no regenerative OA drugs have been approved. Caspase-1, a core effector of the inflammasome, may contribute to OA via both canonical inflammatory and non-canonical functions, but its therapeutic value remains unclear. - Source: PubMed
Publication date: 2025/10/03
Mei JianSchäfer NicoleWei PenghuiKong ZhihengLi ShushanPann PatrickEhrnsperger MarianneJohnstone BrianMatalova EvaGrässel Susanne - The endocannabinoid system (ES) plays a pivotal role in modulating central nervous system activity in response to emotional stimuli. This study aimed to identify and validate biomarkers associated with ES-related genes (ES-RGs) in major depressive disorder (MDD), providing insights into potential therapeutic targets. - Source: PubMed
Publication date: 2025/09/26
Wang LinlinChen MinLi XujuanLi Yufeng - Ischemic stroke (IS) is a leading global cause of mortality and disability, particularly prominent in patients with end-stage renal disease (ESRD). Despite clinical evidence of their comorbidity, the molecular mechanisms underlying their interaction remain elusive. This study aims to identify shared biomarkers, gene regulatory networks, and therapeutic targets through integrative bioinformatics analyses. Gene expression datasets for IS (GSE16561, GSE22255) and ESRD (GSE37171, GSE142153) were obtained from gene expression omnibus (GEO). Weighted gene co-expression network analysis (WGCNA) and differential expression genes (DEGs) analysis identified shared genes and enriched pathways. Protein-protein interaction networks were constructed using STRING with clustering algorithms. Immune cell infiltration analysis was performed via CIBERSORT. Transcriptional regulatory networks were predicted using RcisTarget and miRcode. Key gene expressions were validated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in clinical samples. We identified 417 intersecting genes through WGCNA and 1712 shared differentially expressed genes. Among these, seven key genes (MRPL49, MRPS2, MRPS9, MRPS10, MRPS11, MRPS27, TFB1M) demonstrated central roles in mitochondrial function. Immune infiltration analysis revealed significant correlations with T cells and neutrophils. Pathway enrichment implicated these genes in transforming growth factor beta (TGF-β) signaling, p53 pathway, and G2/M checkpoint. Clinical validation confirmed significant downregulation of MRPS9, MRPS10, MRPS11, MRPS27 and TFB1M in comorbid patients. This study systematically elucidates the mitochondrial-immune interaction mechanisms in IS-ESRD comorbidity, highlighting the pivotal role of mitochondrial ribosomal protein (MRP) family genes in regulating cellular energetics and inflammatory responses. These findings provide new foundations for targeted therapies. - Source: PubMed
Publication date: 2025/05/16
Wang ShuhongLi ZhongdaWang XiaoZhou JiexueMeng ShandongZhuang JinyangZhou YanZhao QinZhu ChunliZhang YushengShen Sheng - A novel valuable prognostic model has been developed on the basis of immune-related genes (IRGs), which could be used to estimate overall survival (OS) in ovarian cancer (OC) patients in The Cancer Genome Atlas (TCGA) dataset and the International Cancer Genome Consortium (ICGC) dataset. - Source: PubMed
Publication date: 2024/10/31
Yu MinLi DanZhang LiWang Ke - Ischaemic stroke is a leading cause of death and severe disability worldwide. Given the importance of protein synthesis in the inflammatory response and neuronal repair and regeneration after stroke, and that proteins are acquired by ribosomal translation of mRNA, it has been theorised that ribosome biogenesis may have an impact on promoting and facilitating recovery after stroke. However, the relationship between stroke and ribosome biogenesis has not been investigated. - Source: PubMed
Publication date: 2024/09/02
Wang XiZhang Xiao-YuLiao Nan-QingHe Ze-HuaChen Qing-Feng