Ask about this productRelated genes to: MRPL36 antibody
- Gene:
- MRPL36 NIH gene
- Name:
- mitochondrial ribosomal protein L36
- Previous symbol:
- -
- Synonyms:
- BRIP1, RPMJ, L36mt, PRPL36, MRP-L36
- Chromosome:
- 5p15.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-26
- Date modifiied:
- 2016-10-05
Related products to: MRPL36 antibody
Related articles to: MRPL36 antibody
- Glioblastoma (GBM) has an extremely poor prognosis. Abnormal mitochondrial function, metabolic disorders, and dysregulated ferroptosis all drive its malignant progression, and the underlying molecular regulatory mechanisms still need further clarification. This study focuses on the regulatory mechanisms linking mitochondrial function, lipid metabolism, and ferroptosis to provide new directions for clinical treatment. - Source: PubMed
Publication date: 2026/06/18
Ye HaonanWen YuqiChen ZhihuaWu LeiZhang ZheZeng JieZhao SiyiFan BowenLiao BinTu XinyuXiong ZhangdaZhang LieliangXia YouyiXie JunZhu HongGuo HuaXiao Feng - Compared to European American women, African American women are more likely to be diagnosed with triple-negative breast cancer (TNBC). This difference may be partially due to genetic factors. This study aims to investigate associations of African ancestry and risk variants with TNBC among African American women. - Source: PubMed
Publication date: 2026/05/07
Jia GuochongLiu LiliPing JieFiorica Peter NGuo XingyiTao RanLi BingshanGu JianJohn Esther MOlopade Olufunmilayo IPress Michael FBrewster Abenaa MOlshan Andrew FZirpoli GaryButler Ebonee NHuang MaoshengHuo DezhengPalmer Julie RHaiman Christopher AAmbrosone Christine BTroester Melissa ALong JirongYao SongZheng Wei - Glioblastoma Multiforme(GBM) is the most common primary malignant tumor of the central nervous system and the most prevalent primary malignant brain tumor in adults, accounting for over 50% of adult malignant primary brain tumors. Adult patients with GBM have a median age at onset ranging from 45.5 to 56 years, with no significant gender difference, and the 5-year survival rate is only 5%-10%. Despite the advancements in surgery and chemoradiotherapy, prognosis remains poor. There is an urgent need to identify novel therapeutic targets and prognostic biomarkers for GBM. Ubiquitin-specific protease 30 (USP30), a member of the deubiquitinating enzyme family, has been implicated in tumor progression. This study investigates the potential mechanisms of USP30 in GBM using proteomic analysis and functional validation. It further explores USP30's potential as a prognostic marker and therapeutic target in GBM, focusing on its downregulation and possible role in tumor suppression. - Source: PubMed
Publication date: 2026/11/05
Wu ChaoYang YanfeiChang XiaotingShang Wei - Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors, with a slow onset, rapid progression, and frequent recurrence. Previous research has implicated mitochondrial ribosomal genes in the development, metastasis, and prognosis of various cancers. However, further research is necessary to establish a link between mitochondrial ribosomal protein (MRP) family expression and HCC diagnosis, prognosis, ferroptosis-related gene (FRG) expression, m6A modification-related gene expression, tumor immunity, and drug sensitivity. - Source: PubMed
Publication date: 2023/07/05
Zhao Jin-WeiZhao Wei-YiCui Xin-HuaXing LinShi Jia-ChengYu Lu - Host genetics, an important contributor to the COVID-19 clinical susceptibility and severity, currently is the focus of multiple genome-wide association studies (GWAS) in populations affected by the pandemic. This is the first study from Serbia that performed a GWAS of COVID-19 outcomes to identify genetic risk markers of disease severity. A group of 128 hospitalized COVID-19 patients from the Serbian population was enrolled in the study. We conducted a GWAS comparing (1) patients with pneumonia ( = 80) against patients without pneumonia ( = 48), and (2) severe ( = 34) against mild disease ( = 48) patients, using a genotyping array followed by imputation of missing genotypes. We have detected a significant signal associated with COVID-19 related pneumonia at locus 13q21.33, with a peak residing upstream of the gene ( = 1.91 × 10). Our study also replicated a previously reported COVID-19 risk locus at 3p21.31, identifying lead variants in and genes suggestively associated with pneumonia ( = 7.54 × 10) and severe COVID-19 ( = 6.88 × 10), respectively. Suggestive association with COVID-19 pneumonia has also been observed at chromosomes 5p15.33 ( = 2.81 × 10), 5q11.2 ( = 6.59 × 10), and 9p23 (, = 8.69 × 10). The genes located in or near the risk loci are expressed in neural or lung tissues, and have been previously associated with respiratory diseases such as asthma and COVID-19 or reported as differentially expressed in COVID-19 gene expression profiling studies. Our results revealed novel risk loci for pneumonia and severe COVID-19 disease which could contribute to a better understanding of the COVID-19 host genetics in different populations. - Source: PubMed
Publication date: 2022/07/14
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