Ask about this productRelated genes to: MRI1 antibody
- Gene:
- MRI1 NIH gene
- Name:
- methylthioribose-1-phosphate isomerase 1
- Previous symbol:
- -
- Synonyms:
- MGC3207, Ypr118w, mtnA, MRDI
- Chromosome:
- 19p13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2009-01-15
- Date modifiied:
- 2014-11-19
Related products to: MRI1 antibody
Related articles to: MRI1 antibody
- BackgroundChronic rhinosinusitis (CRS) contributes to morbidity in cystic fibrosis (CF), and sinus surgery serves as second-line treatment. Magnetic resonance imaging (MRI) was recently shown to differentiate CF-related CRS (CF-CRS) manifestations, and to monitor therapy response, but has not been used to investigate the effects of sinus surgery on CF-CRS.ObjectiveThe aim of this study was to systematically study the effects of sinus surgery on CF-CRS.MethodsTwenty controls with CF (median age 15 years, range 9-33 years) who had not undergone sinus surgery with annual MRI examinations were age-matched to the surgery group. The surgery group comprised 10 individuals with CF (median age 15 years, range 8-32 years) who underwent endoscopic sinus surgery between 2010 and 2018 and underwent MRI in median 2.5 months before (MRI1) and at least one (MRI2) or two (MRI3) annual MRIs after surgery. The median time difference between sinus surgery and MRI2 was 14 months, and between MRI2 and MRI3 it was 13 months. All patients were modulator-naïve. The established CRS-MRI score was used including sinus dimension measurement.ResultsIn controls, the median maxillary sinus width was stable from MRI1 through MRI3 (range 23.0-24.5 mm; > .999). In the surgery group, the median maxillary sinus width decreased from MRI1 to MRI2 (-5.5 mm, < .01), and remained stable from MRI2 to MRI3 (+3.0 mm; = .544). The prevalence of maxillary sinus deformation decreased from MRI1 to MRI2 (-35%; < .05) and was stable from MRI2 to MRI3 (+19%; = .295). The CRS-MRI sum score was stable from MRI1 through MRI3 in controls (median 28, 23 and 34 at MRI1-2-3), and in the surgery group (36, 35 and 39, respectively) ( = .743-.999).ConclusionSinus surgery improves maxillary sinus width and deformation. The CRS-MRI score could not detect further benefits of surgery on CF-CRS. MRI supports the evaluation of sinus surgery in the era of modulator treatment strategies as some patients still suffer from CF-CRS despite optimized modulator treatment and there is a need to identify patients that still might profit from sinus surgery. - Source: PubMed
Publication date: 2026/04/06
Yılmaz Topçuoğlu Miray-SuBaumann IngoKolb VeronikaKauczor Hans-UlrichSommerburg OlafStahl MirjamMall Marcus AEichinger MonikaWucherpfennig LenaWielpütz Mark O - Amino acid metabolic (AAM) reprogramming is a key characteristic of gastric cancer (GC) cells metabolic remodeling, which regulates cell growth, survival, immune cell activation and function to affect tumor immune escape. This study aims to systematically investigate AAM reprogramming in gastric cancer (GC) and construct prognostic model, and validate gene signatures for predictive value and clinical decision-making. This study leveraged data from TCGA and GEO to construct a prognostic model related to AAM and assess its clinical relevance in GC. We identified differentially expressed genes and conducted GO, GSEA, and GSVA enrichment analyses, along with constructing PPI networks and interaction networks of mRNA-miRNA, mRNA-TF, and mRNA-RBP. Additionally, immune infiltration analysis was performed and the relationships between eight hub-type amino acid metabolism-related genes (AAMRGs) and immune cells was investigated using scRNA-seq datasets. Lastly, we validated the elevated expression of these eight genes in GC cells through PCR. The study constructed a prognostic model for GC based on AAMRGs, identifying 16 key genes: ACLY, ADH4, COL1A1, F2, GADL1, GAMT, HBB, KYNU, MRI1, MTHFR, NR1D1, PDK4, SLC1A7, SLC25A15, SLC52A3, and SYCE2. Statistical analysis showed that 14 of these genes showed significant differential expression between tumor and normal tissues. Furthermore, the model demonstrated strong correlations with OS outcomes. Immune infiltration analysis indicated that various immune cell types were significantly associated with the expression of 8 hub genes, highlighting their potential role in the tumor microenvironment and immune response modulation. Furthermore, elevated expression of these genes in GC cells was validated through PCR, highlighting their relevance as potential biomarkers and therapeutic targets. Our AAMRGs prognostic model reveals AAMRGs as independent prognostic factors for GC, highlighting their association with prognosis and immune cell infiltration. These findings provide important insights for improving survival outcomes and advancing immunotherapy strategies in GC. - Source: PubMed
Publication date: 2026/03/05
Zhang HuanYe WeiZeng LingzhiWang LuGui Ling - Ambient air pollution exposures increase risk for Alzheimer's disease (AD) and related dementias, possibly due to structural changes in the medial temporal lobe (MTL). However, previous MRI studies examining exposure effects on the MTL were cross-sectional and mostly focused on the hippocampus, yielding mixed results. We addressed these limitations using longitudinal data collected from 653 cognitively unimpaired community-dwelling women from the Women's Health Initiative Memory Study with two MRI scans (M at MRI-1 =77.3 ± 3.5years). We used linear regressions to examine relationships between 3-year annual average exposures to fine particulate matter (PM) and nitrogen dioxide (NO) prior to MRI-1, and 5-year volume changes in the bilateral hippocampus, amygdala, parahippocampal gyrus (PHG), and entorhinal cortex (ERC), which were summed to operationalize MTL volume. Covariates included intracranial volume, sociodemographic, lifestyle, and clinical characteristics. For each interquartile increase of PM (3.26 µg/m) and NO (6.77 ppb), adjusted MTL volume had greater shrinkage by 0.32 cm (95 %CI=[-0.43,-0.21]) and 0.12 cm (95 %CI=[-0.22,-0.01]), respectively. Exposure effects did not differ by APOE ε4 genotype, sociodemographic, or cardiovascular risk factors. Subregionally, higher PM was associated with greater PHG and ERC atrophy, and higher NO was associated with greater PHG atrophy. Brain associations with PM were not significant among women residing in locations that met air quality standards (PM<9 µg/m). Collectively, late-life PM and NO exposures were associated with greater MTL atrophy in cognitively unimpaired older women, especially in the PHG and ERC. These cortical MTL subregions are among the earliest affected by AD neuropathology - and may be preferentially vulnerable to air pollution neurotoxicity. - Source: PubMed
Publication date: 2025/12/31
Wang XinhuiSalminen Lauren EPetkus Andrew JFrahmand IraMillstein JoshuaBeavers Daniel PEspeland Mark AErus GurayBraskie Meredith NThompson Paul MGatz MargaretChui Helena CResnick Susan MKaufman Joel DRapp Stephen RShumaker SallyBrown MarkYounan DianaChen Jiu-Chiuan - Chiari-like malformation (CM) and syringomyelia (SM) are commonly observed conditions in Pomeranian dogs. Affected dogs may develop clinical signs that significantly impact quality of life. Therefore, it is crucial to select only unaffected dogs for breeding. However, the progression of CM/SM has not been fully elucidated. Dogs that are unaffected or mildly affected may progress to severe SM over time. The primary aim of this study is to investigate the progression of CM/SM through repeated MRI scans. A secondary objective is to evaluate the effect of furosemide treatment on syrinx sizes, given its frequent prescription. - Source: PubMed
Publication date: 2025/07/18
Jansma Mees RHeuvel Marieke van denBossens KennyNoorman ErikHermans MichelleMandigers Paul J J - Neurodevelopmental conditions, such as autism, are highly heterogeneous at both the mechanistic and phenotypic levels. Therefore, parsing heterogeneity is vital for uncovering underlying processes that could inform the development of targeted, personalized support. We aimed to parse heterogeneity in autism by identifying subgroups that converge at both the phenotypic and molecular levels. - Source: PubMed
Publication date: 2025/07/10
Leyhausen JohannaGurr CarolineBerg Lisa MSeelemeyer HannaHermila BassemSchäfer TimChiocchetti Andreas GPretzsch Charlotte MLoth EvaOakley BethanyBuitelaar Jan KBeckmann Christian FCharman TonyBourgeron ThomasBarthome EliBanaschewski TobiasJones Emily J H Murphy DeclanEcker Christine