Ask about this productRelated genes to: MOXD1 antibody
- Gene:
- MOXD1 NIH gene
- Name:
- monooxygenase DBH like 1
- Previous symbol:
- -
- Synonyms:
- DKFZP564G202, MOX, dJ248E1.1
- Chromosome:
- 6q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-06-20
- Date modifiied:
- 2016-04-06
Related products to: MOXD1 antibody
Related articles to: MOXD1 antibody
- Metabolic dysfunction-associated steatohepatitis (MASH) has become a major global health burden yet effective pharmacological treatments remain scarce. Lipotoxicity is one of the central drivers of MASH, but the molecular regulators that control lipid metabolism homeostasis in MASH remain incompletely defined. - Source: PubMed
Publication date: 2026/05/21
Li MeiZhang JinquanYang YunfanTian SongCheng XuLi QidanLi PenglongZhou SiyiShen HongLiu ZixuanMao YichaoLiu DianyuHu YangZhang LiZeng JianyouZhang JunWan JuanZhou JunjieFu JiajunHu ManliYang HailongBai LanZhang XinCai JingjingShe Zhi-GangWang YibinLi HongliangZhang Xiao-Jing - This study aims to identify new genetic loci associated with primary open-angle glaucoma (POAG) and explore shared genetic risk factors across African, European, and Admixed American/Latino populations. Genome-wide Association Study (GWAS) utilizing data from the Research Program. The study included 374,254 participants, with 4,305 individuals diagnosed with POAG and 369,949 controls. Participants were categorized by ancestry: European, African, and Admixed American/Latino. We used short-read sequencing data and applied strict quality control measures (MAF > 0.01, INFO > 0.8). GWAS were conducted for each ancestry group using a logistic mixed model, adjusting for age, sex, and the top 11 principal components. A fixed-effect meta-analysis combined the results across ancestries. Genome-wide significance was set at < 5 × 10. The primary outcome measures were the identification of genetic loci associated with POAG, and the analysis of transcription factors linked to these loci in relevant tissues. In the European cohort, we identified four novel loci associated with POAG, linked to the ,,, genes, as well as the previously known locus. In the African cohort, we found five new loci, including ,,,,. For the Admixed American/Latino cohort, we identified ,, genes as novel loci. Our analysis identified three novel loci in individuals of European ancestry, mapped to the genes ,,. We identified 56 genome-wide significant variants, including six putative novel loci, and found that most ancestry-specific signals replicated in the cross-ancestry meta-analysis, with the exception of several attenuated associations in the smaller Admixed American/Latino cohort. These findings indicate that the genetic determinants contributing to POAG may differ across populations, underscoring the importance of accounting for population-specific genetic architectures in the study of complex traits. Given the substantial variation in POAG prevalence among ancestries, it is plausible that certain genetic variants exert ancestry-specific effects. Consequently, conducting ancestry-stratified GWAS is essential for elucidating these unique genetic contributions. - Source: PubMed
Publication date: 2026/03/17
Tavakoli KianaHuang Bonnie BMirmira TaraMa NicholeWeinreb Robert NBaxter Sally L - This study aims to identify new genetic loci associated with primary open-angle glaucoma (POAG) and explore shared genetic risk factors across African, European, and Admixed American/Latino populations. Genome-wide Association Study (GWAS) utilizing data from the Research Program. The study included 374,254 participants, with 4,305 individuals diagnosed with POAG and 369,949 controls. Participants were categorized by ancestry: European, African, and Admixed American/Latino. We used short-read sequencing data and applied strict quality control measures (MAF > 0.01, INFO > 0.8). GWAS were conducted for each ancestry group using a logistic mixed model, adjusting for age, sex, and the top 11 principal components. A fixed-effect meta-analysis combined the results across ancestries. Genome-wide significance was set at p<5×10. The primary outcome measures were the identification of genetic loci associated with POAG, and the analysis of transcription factors linked to these loci in relevant tissues. In the European cohort, we identified four novel loci associated with POAG, linked to the genes, as well as the previously known locus. In the African cohort, we found five new loci, including . For the Admixed American/Latino cohort, we identified genes as novel loci. Our analysis identified three novel loci in individuals of European ancestry, mapped to the genes . In addition, five novel loci were detected in the GWAS of African ancestry participants, and four novel loci were identified in individuals of Admixed American/Latino ancestry. These findings indicate that the genetic determinants contributing to POAG may differ across populations, underscoring the importance of accounting for population-specific genetic architectures in the study of complex traits. Given the substantial variation in POAG prevalence among ancestries, it is plausible that certain genetic variants exert ancestry-specific effects. Consequently, conducting ancestry-stratified GWAS is essential for elucidating these unique genetic contributions. - Source: PubMed
Publication date: 2025/10/26
Tavakoli KianaHuang Bonnie BMirmira TaraMa NicholeWeinreb Robert NBaxter Sally L - The invasive golden apple snail, , threatens agriculture and public health globally. This study systematically investigates the molluscicidal mechanism of theasaponin E1 (TSE1), a tea saponin monomer. TSE1 exhibited concentration- and time-dependent toxicity. Transcriptomics revealed dysregulation of cholesterol homeostasis, including marked upregulation of , , and cholesterol catabolic enzymes (, ). Concurrently, sphingolipid metabolism exhibited dual perturbation, with both sphingomyelin accumulation and ceramide elevation mediated by differential expression of and . Ultrastructural analysis showed mitochondrial cristae dissolution and membrane rupture, with ferroptosis activation through voltage-dependent anion channel 2 upregulation and oxidative stress. Notably, granulocytes displayed distinct resistance to TSE1-induced cytotoxicity, suggesting cell-type specific protective mechanisms. These findings establish that TSE1 exerts its molluscicidal effect through coordinated disruption of lipid homeostasis, culminating in iron-dependent cell death. The conserved ferroptotic pathway and cell-selective vulnerabilities identified in this study provide critical insights for developing targeted, environmentally sustainable molluscicides. - Source: PubMed
Publication date: 2025/11/06
Ma Cheng-JunLiao Gui-MingHan Yan-WeiChen PeiWang Xin-AoLi Jia-WeiHou YoumingTang Baozhen - Heart failure (HF) represents the end stage of cardiovascular disease and is the leading cause of mortality. The objective of this study was to identify potential biomarkers and elucidate the mechanisms underlying the development of HF across diverse populations and among different genders. - Source: PubMed
Publication date: 2025/10/14
Yu YueXue ChentianJi DongSheng WeiGao XiangWu XizeWu Chengyan