Ask about this productRelated genes to: MOGS antibody
- Gene:
- MOGS NIH gene
- Name:
- mannosyl-oligosaccharide glucosidase
- Previous symbol:
- -
- Synonyms:
- GCS1, CWH41, DER7
- Chromosome:
- 2p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2009-03-24
- Date modifiied:
- 2019-04-23
Related products to: MOGS antibody
Related articles to: MOGS antibody
- The spike (S) protein of SARS-CoV-2 is extensively glycosylated, with N-glycosylation sites remaining highly conserved during viral evolution. While inhibiting N-glycosylation has been shown to significantly suppress SARS-CoV-2 infection, the underlying molecular mechanisms remain incompletely characterized. Here, we identify that two N-glycosylation sites, N61 and N343, are critical for spike maturation. We demonstrate that asparagine-to-aspartic acid substitutions (N to D) at these sites lead to endoplasmic reticulum (ER) retention of the S protein, with consequent abrogation of S1/S2 cleavage and near-complete elimination of viral infectivity. IP-MS analysis further reveals that the COPI complex, which facilitates retrograde Golgi-to-ER transport, is a key participant in this ER retention process. Additionally, inhibition of COPI effectively restores the plasma membrane localization of N61D- and N343D-mutated S proteins and enhanced viral infectivity. More importantly, a specific inhibitor has been developed that effectively blocks the ER-to-Golgi trafficking of the S protein, thereby broadly abolishing viral infectivity across SARS-CoV-2 variants. Overall, our study reveals the unique roles of N-glycosylation in the regulation of S protein maturation, providing a potential mechanistic target for antiviral drug development.IMPORTANCEN-glycosylation of the spike protein is critical for SARS-CoV-2. While most studies have focused on the effects on spike-ACE2 binding and neutralizing antibody recognition, few studies have reported how N-glycosylation regulates S protein maturation, with the underlying molecular mechanisms remaining poorly understood. Here, we demonstrate that N-glycosylation at N61/ N343 contributes to spike ER-to-Golgi trafficking. Specifically, defects in S protein's N-glycosylation (including mutations at N61 or N343, N-glycosylation inhibitors treatment, and MOGS depletion) result in ER retention through COPI-mediated retrograde Golgi-to-ER transport, and thus, the S proteins are not effectively cleaved by furin in the Golgi. This impairment of S protein maturation leads to a significant reduction in viral infectivity, which highlights the key role of N-glycosylation at residues N61 and N343 in SARS-CoV-2 life cycle. Overall, our findings uncover the molecular mechanism by which N-glycosylation controls SARS-CoV-2 spike intracellular trafficking, offering novel insights for anti-SARS-CoV-2 strategies. - Source: PubMed
Publication date: 2026/03/30
Kong WeiliZhang JialiSong YingyingSong JingjingXu YueboXu XinmuMa HaoyuChen LiZeng Cong - Biomimetic ion channels demonstrate potential for nanoscale molecular separations by leveraging their unique confined recognition capabilities. Metal-organic framework (MOF)-based mixed matrix membranes (MMMs) offer a promising platform that integrates the ångström-scale pores of MOFs with polymer processability. However, slow MOF nucleation kinetics and weak interfacial interactions impede precise channel formation. Here, we present a confined molecular encapsulation (CME) strategy that synchronously regulates MOF nucleation kinetics and interfacial interactions, transforming precursors into flexible gel-network metal-organic gels (MOGs) via supramolecular assembly. Molecular dynamics simulations and in-situ optical detection show that stronger MOG-polymer interactions and confined diffusion govern enhanced interfacial compatibility and uniform dispersion. Optimized MMMs deliver a F⁻/Cl⁻ separation ratio of 32.0 with ionic current rectification. COMSOL simulations demonstrate that synergistic coupling of aligned MOF arrays and uniform surface charge enables efficient ion differentiation. This CME strategy establishes a versatile nanoscale platform for fabricating high-performance monovalent ion-selective membranes and nanofluidic devices. - Source: PubMed
Publication date: 2026/03/28
Chen QianLiu Mei-LingJiang ShengZhang Yu-TongJia Yue-WenLi Wei-XingSun Shi-PengXing Weihong - - Source: PubMed
Publication date: 2026/03/18
Tian JingranZong HuannaWang QihaoZhu Liwei - Crystal-liquid-glass phase transitions in coordination polymers (CPs) and metal-organic frameworks (MOFs) have opened new opportunities for materials processing and for accessing novel or enhanced functionalities inherited from their crystalline precursors. However, strategies to modulate the properties of the resulting glassy states, collectively referred to as metal-organic glasses (MOGs), have primarily relied on crystal engineering. Such approaches face intrinsic limitations, as the rare occurrence of melting behavior in CPs/MOFs and the narrow compositional windows that sustain a stable liquid phase restrict access to new structures and properties. Inspired by the compositional tunability of conventional oxide glass, this work explores a strategy to modulate MOG properties by incorporating inorganic zirconium hydrogen phosphate as a secondary network former. We hypothesize that the mismatch between tetrahedrally coordinated Zn in the parent MOG and octahedrally coordinated Zr in the additive induces distinct structural and functional modifications. By systematically varying the content of the zirconium hydrogen phosphate, we demonstrate a linear increase in the glass transition temperature, viscosity, and anhydrous proton conductivity, reaching 2.6 mS cm at 150°C. These results highlight the potential of translating design principles from inorganic glass science to fine-tune the properties of MOGs. - Source: PubMed
Publication date: 2026/02/13
Ma NattapolAndo HidekaMa RenzhiNakanishi Takashi - In the pursuit of a technological breakthrough in zinc-air batteries, it is critical to find economical, durable, and high-performance catalysts for the oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) to accelerate the slow reaction kinetics. Herein, a one-pot method was employed to synthesize the polymer within a mixed solvent of CHCl and CHOH (v/v = 2:1). The resulting polymer can be well-dispersed in deionized water to form an aqueous metal-organic gel (MOG). Testing has revealed that Co-MOG exhibits dual catalytic properties for both the OER and ORR, a characteristic that is notably rare in original MOG materials. Furthermore, it demonstrates exceptional long-term charge-discharge cycling stability in zinc-air batteries, outperforming several reported Co-based catalysts for the OER and ORR. X-ray absorption spectroscopy and density-functional theory (DFT) calculations indicate that the CoN configuration serves as the catalytically active site of the material. In conclusion, this work supports the application of MOGs as unique bifunctional electrocatalysts for the OER and ORR in metal-air batteries. - Source: PubMed
Publication date: 2026/02/03
Chen YutingTang WeichengGuo XiaoyuZhao XiaohanDu YunmeiXing JunWang LeiLiu Kang