Ask about this productRelated genes to: MOGS antibody
- Gene:
- MOGS NIH gene
- Name:
- mannosyl-oligosaccharide glucosidase
- Previous symbol:
- -
- Synonyms:
- GCS1, CWH41, DER7
- Chromosome:
- 2p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2009-03-24
- Date modifiied:
- 2019-04-23
Related products to: MOGS antibody
Related articles to: MOGS antibody
- Moral emotions are increasingly implicated in the maintenance of eating disorders (EDs), yet guilt is less differentiated than shame in the ED literature. Contemporary cognitive accounts distinguish deontological guilt linked to violating internalised moral norms from altruistic guilt linked to empathic concern or perceived harm to others. This study examined associations between guilt facets, ED diagnosis, and ED psychopathology in a clinical sample. One hundred and eleven adult outpatients (≥18 years) with DSM-5 ED diagnoses (anorexia nervosa, = 32; bulimia nervosa, = 24; binge-eating disorder, = 55; 92 women) were consecutively recruited at first assessment at the Eating Disorders Centre of the University of Campania "Luigi Vanvitelli" (Naples, Italy) between January 2024 and December 2025 and completed the Italian versions of the Moral Orientation Guilt Scale (MOGS) and the Eating Disorder Inventory 2 (EDI-2). Between-diagnosis differences in guilt facets were tested using Kruskal-Wallis analyses. Spearman correlations examined relationships between MOGS facets and EDI-2 subscales. An exploratory regression tested whether MOGS Empathy was associated with EDI-2 Asceticism beyond sex. Significant between-diagnosis differences emerged for Moral Norm Violation ( < 0.001), Moral Dirtiness ( = 0.020), Harm ( = 0.021), and both deontological ( = 0.001) and altruistic guilt composites ( = 0.041), with binge-eating disorder showing the highest mean levels. No between-diagnosis difference emerged for Empathy ( = 0.114). The prespecified MNV-Bulimia correlation was not confirmed (ρ = 0.12, unadjusted = 0.199; Holm-adjusted = 0.199). Empathy was associated with Asceticism (ρ = 0.28, unadjusted = 0.003; Holm-adjusted = 0.008), and altruistic guilt was associated with Interpersonal Distrust (ρ = 0.24, unadjusted = 0.010; Holm-adjusted = 0.020). Broader exploratory correlations did not survive false discovery rate correction. In a regression model including sex, Empathy was associated with Asceticism (B = 0.263, 95% CI 0.078-0.447; standardised β = 0.26; = 0.006), explaining approximately 7% of the variance (R = 0.07). Distinct guilt facets show selective, small-to-moderate associations with ED-related psychological traits in an adult outpatient sample. These findings are hypothesis-generating and require replication in larger and longitudinal samples that include shame, trauma, self-criticism, weight stigma, illness duration, and gender identity measures. - Source: PubMed
Publication date: 2026/09/07
Raffone FabiolaBarone EugeniaAtripaldi DaniloArsenio EleonoraMartinelli FlaviaCruccu SerenaCarfagno MarcoMartiadis VassilisMonteleone Alessio Maria - Biomass-based conductive aerogels with excellent biocompatibility, high porosity, and facile functionalization are the key materials for new-generation sustainable high-performance piezoresistive sensors. However, the single lamellar structure of conventional aerogels and the inherent agglomeration tendency of conductive nanomaterials severely hamper the mechanical and strain sensing properties of biomass-based aerogels. Herein, inspired by the natural bamboo-node structure, a novel gelation-confinement strategy was developed to construct a unique bamboo-node-reinforced structure by incorporating metallogels (MOGs) and carbon nanotubes (CNTs) into cellulose nanofibers (CNFs). The resulting CNF-based aerogel exhibits excellent mechanical stability and can withstand over 5000 compression cycles at 50% strain. Meanwhile, integration of the aerogel into a flexible piezoresistive sensor endows the device with comprehensive strain sensing properties, including high linear sensitivity (S = 4.14 kPa in the 0-2 kPa range; S = 1.88 kPa in the 2-92 kPa range) and a low-pressure detection limit of 2.21 Pa. These multifunctional features endow the composite aerogel with great application potential in motion monitoring. - Source: PubMed
Publication date: 2026/09/03
Liao FengxiDong JianmeiXiao HongyiLuo JunjieDiao XinyangYang FeiLi Bo - We report a highly efficient strategy for the synthesis of a novel class of amorphous, small-molecule organic glass formers (MOGs) derived from pentafluoropyridine (PFP). Utilizing a single-step, atom-economical, and highly scalable nucleophilic aromatic substitution SAr platform, a series of bistetrafluoropyridine aryl ethers (BTFPAEs) were prepared in excellent yields. This orthogonal approach leverages molecular asymmetry and rigid core architecture to effectively suppress crystallization, addressing a historical limitation of traditional MOGs. Thermal analysis revealed two discrete regimes of glassing behavior. Class I systems exhibit exceptional morphological stability, undergoing an irreversible transition to a robust, transparent amorphous glass upon initial melting with glass transition temperatures ( ) precisely tunable between -15 °C and 53 °C. Exploiting this stability, we demonstrate the fabrication of homogeneous, melt-blended binary glasses with predictable, programmable profiles that adhere strictly to the Fox equation. Class II systems yield highly versatile, metastable semi-amorphous matrices through controlled cooling dynamics. This work establishes a predictable structure-property relationship governing molecular symmetry, internal flexibility, and phase behavior, demonstrating that these resilient BTFPAE architectures hold significant promise as tailorable host matrices for a range of advanced material applications. - Source: PubMed
Publication date: 2026/09/18
Weeks Nathan JSpeicher Anika AIacono Scott T - Total elimination of replication-competent human immunodeficiency virus type 1 (HIV-1) remains a major clinical challenge, in part due to random integration of the proviral DNA into host cell chromosomes, which enables lifelong persistence and production of progeny. Although antiretroviral therapies (ARTs) suppress viral replication, they cannot eliminate integrated proviral DNA, which remains a fundamental obstacle to achieving a cure. To overcome this problem, we developed a combinatorial clustered regularly interspaced short palindromic repeats-Cas9 gene editing strategy to disrupt viral replication and inactivate host factors essential for HIV-1 entry and spread. This approach targets C-C chemokine receptor type 5 (CCR5), a chemokine receptor central to HIV-1 host cell entry, and mannosyl-oligosaccharide glucosidase (MOGS), a key enzyme in glycoprotein processing that modifies the HIV-1 envelope glycoprotein gp120, facilitating receptor engagement, viral entry, and morphogenesis of infectious virion. We demonstrate that our strategy, which includes editing of the integrated proviral DNA, in concert with two cellular genes whose products facilitate viral entry, results in robust suppression of viral replication and in -infected cells. Using transmission electron microscopy, HIV-1 p24 ELISA, and GFP-based viral infection assays, we show that the combination knockout of CCR5, MOGS, and viral sequences profoundly reduces HIV-1 replication in an cellular model, that is, HIV-1-infected peripheral blood mononuclear human cells, thus offering a pathway to launch further preclinical studies. - Source: PubMed
Publication date: 2026/08/23
Safaei ZahraBellizzi AnnaLiu HongHuang YuruSariyer Ilker KKhalili Kamel - Congenital disorders of glycosylation (CDGs) are rare metabolic diseases characterized by clinical heterogeneity, yet the molecular basis for their tissue-specific manifestations remains poorly understood. Because affected tissues are rarely accessible for biopsy, the baseline transcriptional and regulatory landscape of CDG-causative genes in healthy human tissues offers a valuable, complementary perspective on tissue vulnerability. Here, we performed an in silico study of the expression, allelic regulation, expression quantitative trait loci (eQTLs), and associations with immune cell compositions of 12 CDG-causative genes across healthy human tissues using multi-omics datasets from the Adult GTEx project. The selected panel includes the most prevalent multisystem CDGs (PMM2-, ALG6-, ALG1-, SLC35A2-, ALG13-, SRD5A3-, MAN1B1-, DPAGT1-CDG), three immune-relevant CDGs classified as inborn errors of immunity (MOGS-, PGM3-, VPS13B-CDG), and the autosomal recessive form of GNE-CDG (GNE-CDG (ar); GNE myopathy) as a tissue-restricted contrast. CDG-causative genes were broadly but heterogeneously expressed, with substantial inter-individual variation. Tissues frequently affected in the corresponding disorders did not consistently display the highest baseline gene expression, underscoring that higher gene expression alone is a poor indicator of tissue susceptibility. Allele-specific analyses revealed five distinct allelic expression patterns across individuals and identified tissue-specific deviations from balanced biallelic expression for several genes, most notably , , , and . Tissue-specific eQTLs affecting CDG genes were frequently located in intronic enhancers of unrelated genes or intergenic regions, revealing a complex, predominantly distal regulatory architecture. Several eQTLs overlapped GWAS Catalog traits and ClinVar entries relevant to the corresponding CDG phenotypes, including PMM2 eQTLs associated with reduced gene levels. Finally, correlations between CDG-causative gene expression and immune cell composition recapitulated known immune phenotypes from blood and suggested additional tissue-dependent roles for glycosylation in immune modulation, that warrant functional validation. Together, these findings demonstrate that CDG-causative genes operate within diverse transcriptional, allelic, and regulatory contexts across human tissues. Our in silico framework provides an interpretable candidates and foundational reference for interpreting tissue vulnerability in CDG and underscore the need for global analyses to fully understand organ-specific disease mechanisms. - Source: PubMed
Publication date: 2026/07/08
Neves Cátia JGomes AntónioLourenço Rita ABarbosa MarianaGrosso Ana RVideira Paula A