Ask about this productRelated genes to: MNDA antibody
- Gene:
- MNDA NIH gene
- Name:
- myeloid cell nuclear differentiation antigen
- Previous symbol:
- -
- Synonyms:
- PYHIN3
- Chromosome:
- 1q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-06-29
- Date modifiied:
- 2017-03-23
Related products to: MNDA antibody
Related articles to: MNDA antibody
- This study aimed to assess the potential diagnostic utility of immune receptor translocation-associated protein 1 (IRTA1) and myeloid nuclear differentiation antigen (MNDA) expression in marginal zone lymphoma (MZL). We evaluated whole-tissue sections from 686 specimens; specifically, reactive lymphoid hyperplasia (n=60), MZL (n=284), follicular lymphoma (n=156), mantle cell lymphoma (n=64), chronic lymphocytic leukaemia/small lymphocytic lymphoma (n=51), lymphoplasmacytic lymphoma (n=17), and diffuse large B-cell lymphoma (DLBCL; n=54). Immunohistochemical staining for IRTA1, MNDA, and other markers (CD10, BCL-6, CD5, CD23, cyclin D1, SOX-11, and LEF-1) was performed using an automated system. IRTA1 was expressed in 62.3% (177/284) of MZL vs 8.7% (25/288) of other small B-cell lymphoma and 14.81% (8/54) of DLBCL specimens (p<0.001 and p<0.001, respectively). MNDA was expressed in 60.9% (173/284) of MZL vs 24.7% (71/288) of other small B-cell lymphoma and 25.93% (14/54) DLBCL specimens (p<0.001 and p<0.001, respectively). Expression of IRTA1 had a higher specificity than MNDA for MZL. Expression of either IRTA1+ or MNDA+ was detected in 78.9% (224/284) of MZL specimens, whereas coexpression was less common (44.4%, 126/284). Within MZL subtypes, IRTA1 and MNDA were expressed at lower frequencies in nodal MZL (55.7% and 55.7%, respectively) than in mucosa-associated lymphoid tissue lymphoma (64.1% and 62.7%, respectively). Expression of IRTA1 alone, or either IRTA1+ or MNDA+, was less frequent among MZL with plasma cell differentiation than among MZL with classical cell morphology (p=0.063 and 0.071, respectively), albeit not significantly. IRTA1 and MNDA are sensitive and specific markers for the differential diagnosis of MZL, and they may be helpful in distinguishing MZL from histologic mimics. - Source: PubMed
Publication date: 2026/03/19
Zhang Wen-WenKe Long-FengWu Chen-YuLu Shu-YiXie Yun-LiZhu Huan-HuanZhu Wei-FengChen GangChen Yan-Ping - Understanding how ageing affects brain function remains a central challenge in neuroscience. Electrophysiological brain imaging techniques provide a near-direct measure of neuronal activity, which is useful for characterising neurophysiological health. They offer us the ability to track large-scale networks of functional activity with high temporal precision. The effects of healthy ageing on these networks remain poorly understood, in part due to small sample sizes and limited control for confounding factors in previous studies. Here, we analysed resting-state source-reconstructed magnetoencephalography (MEG) data from a large cross-sectional cohort of healthy adults ( = 612, 18-88 years old) to characterise the effect of age using not only time-averaged (static), but also transient (dynamic) network activity. We examined time-averaged power and coherence across canonical frequency bands ( , , , , ), as well as transient network dynamics identified using Hidden Markov Modelling. We included many confounding variables known to be affected by age, such as brain volume, as well as head size and position, which have previously been overlooked. Ageing was associated with frequency-specific changes in oscillatory power, with decreases in low-frequency ( , ) power and increases in high-frequency ( ) power. Coherence increased across all frequency bands and was positively associated with cognitive performance. Transient network analyses additionally revealed that frontal network occurrences declined with age, with evidence suggesting a compensatory role in supporting cognition. These findings provide a more comprehensive electrophysiological signature for healthy ageing and establish a baseline for detecting pathological change. - Source: PubMed
Gohil ChetanKohl OliverPitt Jemmavan Es Mats W JQuinn Andrew JVidaurre DiegoTurner Martin RNobre Anna CWoolrich Mark W - Aging is a myeloid-biased process, i.e., the differentiation of myeloid cells increases, while the lymphoid lineage declines. Cellular senescence increases the secretion of inflammatory mediators which skew hematopoiesis toward myeloid cell generation. Myeloid cell nuclear differentiation antigen (MNDA) is a type-1 interferon (IFN)-inducible factor which is mainly expressed in the cells of the granulocyte-monocyte lineage, especially it is enriched in M2 macrophages and myeloid-derived suppressor cells (MDSC). MNDA regulates gene expression in the cooperation with the IRF7, Sp1, and YY1 transcription factors. MNDA also inhibits the function of two antiapoptotic proteins, i.e., MCL1 and BCL2, thus promoting apoptotic clearance of myeloid cells during the resolution of inflammation. Moreover, MNDA can prevent excessive inflammation by inducing the polarization of M2 macrophages and enhancing the recruitment of MDSCs into inflamed tissues. Immunosuppressive cells not only inhibit inflammation but they can also promote senescence of immune and non-immune cells as well as triggering fibrosis and other age-related alterations. We propose a scenario where the accumulation of senescent cells with aging promotes a leakage of double-stranded DNA (dsDNA) from impaired mitochondria and nuclei thus activating cytoplasmic dsDNA sensors. Activation of cGAS-STING signaling generates the production of type-1 IFNs and thus MNDA may potentially enhance the myeloid-biased aging process and aggravate many age-related diseases. - Source: PubMed
Publication date: 2026/03/24
Salminen AnteroKaarniranta KaiKauppinen Anu - The paraspeckle is a disease-relevant biomolecular condensate assembled from long non-coding RNA (lncRNA) NEAT1_2 ribonucleoprotein particles. Paraspeckle biogenesis is suppressed in normal tissues, yet it can be rapidly upregulated under stress. Here we demonstrate that a neurodegeneration-linked RNA-binding protein TDP-43 inhibits NEAT1_2 ribonucleoprotein particle condensation into the paraspeckle, in a concentration-dependent manner, which requires its intact polymerization and RNA binding. This effect is counterbalanced by core paraspeckle proteins such as FUS. Below disruptive concentrations, TDP-43 can be recruited into paraspeckles, forming non-liquid clusters. Under stress, TDP-43 sequestration into de novo nuclear condensates alleviates paraspeckle suppression and increases their dynamism. NEAT1_2 middle-part and 3'-end UG repeats mediate paraspeckle regulation by TDP-43 cotranscriptionally and post assembly, respectively. The deletion of the 3'-end UG repeat increases paraspeckle stability and cytoprotection in stressed human neurons. Consistently, longer 3'-end UG repeats are linked to shorter survival in the neurodegenerative disease amyotrophic lateral sclerosis. Thus, TDP-43 is a critical regulator of paraspeckle condensates linked to cytoprotection. - Source: PubMed
Publication date: 2026/03/18
Hodgson Rachel EHuang Wan-PingLang RuaridhKumar VedanthAn HaiyanStender Emil G PChalakova Zhaklin PDriver Mark DSanchez Avila AnnaEllis Brittany C SDay EmilyRayment Jessica ABaeg KyungminStrange AndrewMoll TobiasWright Gareth S Avan Vugt Joke J F A Allen Scott PLocker NicolasPitout IantheFletcher SusanOnck Patrick RDuss OlivierCooper-Knock JohnathanShelkovnikova Tatyana A - The objective of this scoping review was to map existing literature on oral health and related care in individuals with Motor Neurone Disease (MND). Specifically, the review aimed to identify barriers and facilitators to maintaining oral hygiene, summarise available clinical guidelines and patient-facing resources, and examine how oral health care is integrated within multidisciplinary management of MND. - Source: PubMed
Publication date: 2026/03/11
Khokhar Mariam AO'Malley Lucy AGlenny Anne-MarieChen Xiaohui