Ask about this productRelated genes to: MMP9 antibody
- Gene:
- MMP9 NIH gene
- Name:
- matrix metallopeptidase 9
- Previous symbol:
- CLG4B
- Synonyms:
- -
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-14
- Date modifiied:
- 2015-02-23
Related products to: MMP9 antibody
Related articles to: MMP9 antibody
- Carbon nanodots were synthesized from Chaenomeles speciosa flowers and comprehensively characterized. UV-Vis analysis revealed a broad absorption band from 200 to 400 nm, attributed to π→π* (200-250 nm) and n→π* (250-350 nm) transitions, while fluorescence under 365 nm excitation showed bright blue emission. HRTEM images indicated spherical nanoparticles forming clustered aggregates, with lattice fringes exhibiting interplanar spacings of 0.091-0.093 nm, confirming a partially graphitic structure. XRD analysis showed a broad amorphous baseline in the 10-40° 2θ range, indicating low crystallinity. FTIR and XPS analyses identified abundant surface -OH, C = O, and C-O groups, with elemental composition of C 68.28%, O 23.03%, N 6.70%, S 0.40%, and Si 1.59%, resulting in a C/O ratio of 2.97. Chaenomeles speciosa quantum dots (CS-CQDs) exhibited dose-dependent cytotoxicity in MDA-MB-231 cells (viability: 70% at 2.5 mg/mL, 60% at 5 mg/mL) and HeLa cells (approximately 50% at 2.5-5 mg/mL), with minimal effects on hTERT-HME1 cells (viability greater than 85% at 0.6 mg/mL). Apoptosis increased from 25% to 55% in MDA-MB-231, from 24% to 65% in HeLa, and from 5.9% to 25% in HME1, with negligible necrosis. Gene expression analyses showed NF-κB upregulation (3-fold in MDA-MB-231; 6-fold in HeLa), BAX and BCL-2 upregulation in HeLa (approximately 2.5-fold), and downregulation of HIF1A, IL-6, MMP2, and MMP9. Wound healing assays indicated reduced migration in MDA-MB-231 (44% to 21%), increased migration in HeLa (18.7% to 30%), and minimal change in HME1 (73.5% to 71.5%). These results demonstrate that CS-CQDs possess favorable optical and structural properties and selectively induce apoptosis in cancer cells, with minimal impact on non-cancerous cells, highlighting their potential as targeted anticancer nanomaterials. - Source: PubMed
Publication date: 2026/04/29
Sarı Zeynep BetülGümrükçüoğlu AbidinTorunoğlu Emine İncilaySarı Muhammet EminAytar Erdi Can - Dry eye disease (DED) is a prevalent ocular disorder driven by tear film instability and inflammation. The quantitative measurement of molecular biomarkers in tears can provide reliable and accurate diagnosis and management of DED. This article introduces a porous microneedle-assisted electrochemical aptamer biosensor for the collection and quantitative analysis of DED-associated biomarkers in tears. The porous microneedle component collects tears while the electrochemical aptamer sensor detects interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and matrix metalloproteinase-9 (MMP-9) with the detection limit of 4.46 pg mL, 1.56 pg mL, and 4.97 ng mL, respectively. Clinically, DED is associated with 13 pg mL of IFN-γ, 4 pg mL of TNF-α, and MMP-9 concentrations of more than 40 ng mL in tears, which are above the detection limits of our sensors. By taking MMP-9 as a model biomarker, we demonstrate a complete collection-to-detection workflow using this microneedle-aptamer biosensing device, which would facilitate the realization of point-of-care monitoring of DED. - Source: PubMed
Publication date: 2026/04/28
Ko Eira BeryleHu TianliZhang YaWang XueyanSong YuXu Chenjie - Whether gradations in glycemia across non-diabetes, prediabetes, and diabetes relate to tear-film homeostasis and dry eye disease (DED) remains uncertain, and explicitgraded association evidence is limited. - Source: PubMed
Publication date: 2026/04/13
Xiang HuanZhou Zengsheng - Autism Spectrum Disorder (ASD) is a genetically heterogeneous neurodevelopmental condition involving multiple genes. This study aimed to comprehensively review the genetic landscape of ASD in the Iranian population, identifying gene variants associated with increased risk, to facilitate improved diagnosis and targeted interventions. A systematic review and meta-analysis were conducted on genetic association studies of ASD in Iran up to August 2025. Comprehensive searches were performed in PubMed, Scopus, Web of Science, and Persian databases using relevant keywords. Quality assessment was performed using the Joanna Briggs Institute critical appraisal tools. Meta-analyses were carried out using Review Manager software, assessing heterogeneity and publication bias. Protein-protein interaction networks were constructed via STRING and analyzed with Cytoscape to identify key hub genes and enriched neurodevelopmental pathways. In this study, genes RORA, MTRR, MTR, Reelin, VDR, VMAT1, ACE I/D, MOCOS, HOTAIR, ANRIL, RIT2, MMP-9, GRM7, FOXP3, and GRIN2B showed significant associations with the occurrence of autism. Findings reinforce associations between multiple gene polymorphisms, especially RORA rs4774388 and MOCOS rs594445, with the risk of ASD. This systematic review and meta-analysis emphasize the multifactorial genetic contributions to ASD in the Iranian population, highlighting key risk loci and neurodevelopmental pathways. The findings underscore the importance of integrating genetic, epigenetic, and environmental factors for understanding ASD etiology and developing population-tailored diagnostic and therapeutic strategies. Future studies employing larger cohorts and multi-omics approaches are warranted to further elucidate the complex genetic architecture of ASD in diverse ethnic groups. - Source: PubMed
Barfeh DelaramShahesmaeilinejad ArmitaEslami Shahrbabaki MahinKaramooz AnahitaShekari FatemehZare Arashlouei Azam - We investigated the antitumor effects of magnolol on T98G glioblastoma multiform cells and explored its underlying mechanisms, with a focus on oxidative stress modulation. - Source: PubMed
Publication date: 2026/04/25
Zand MohammadLatifi Seyyed AmirhosseinSalehi MehdiKarami Hadi