Ask about this productRelated genes to: MAGEC3 antibody
- Gene:
- MAGEC3 NIH gene
- Name:
- MAGE family member C3
- Previous symbol:
- -
- Synonyms:
- HCA2, MAGE-C3, CT7.2
- Chromosome:
- Xq27.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-10
- Date modifiied:
- 2015-11-13
Related products to: MAGEC3 antibody
Related articles to: MAGEC3 antibody
- Colon cancer (CC) in Saudi Arabia is associated with a high death rate and is commonly identified at a more progressive stage. Therefore, it is critical to identify and characterize potential novel cancer-specific biomarkers to enhance early CC diagnosis. The goal was to assess their potential use as cancer biomarkers for the early detection and improvement of CC treatment. - Source: PubMed
Publication date: 2024/10/29
Almutairi Mikhlid HAlsoraie Waad AAlrubie Turki MAlkhaldi Ahmad SAlhajri Nada SAlaujan Monira AAlmutairi Manar HAlmutairi Bader O - Human aging is marked by the emergence of a tapestry of clonal expansions in dividing tissues, particularly evident in blood as clonal hematopoiesis (CH). CH, linked to cancer risk and aging-related phenotypes, often stems from somatic mutations in a set of established genes. However, the majority of clones lack known drivers. Here we infer gene-level positive selection in whole blood exomes from 200,618 individuals in UK Biobank. We identify 17 additional genes, ZBTB33, ZNF318, ZNF234, SPRED2, SH2B3, SRCAP, SIK3, SRSF1, CHEK2, CCDC115, CCL22, BAX, YLPM1, MYD88, MTA2, MAGEC3 and IGLL5, under positive selection at a population level, and validate this selection pattern in 10,837 whole genomes from single-cell-derived hematopoietic colonies. Clones with mutations in these genes grow in frequency and size with age, comparable to classical CH drivers. They correlate with heightened risk of infection, death and hematological malignancy, highlighting the significance of these additional genes in the aging process. - Source: PubMed
Publication date: 2024/05/14
Bernstein NicholasSpencer Chapman MichaelNyamondo KudzaiChen ZhenghaoWilliams NicholasMitchell EmilyCampbell Peter JCohen Robert LNangalia Jyoti - Primary hepatic sarcomatoid carcinoma (HSC) is an extremely rare and aggressive subtype of primary liver cancer. HSC has uncertain pathogenesis and dismal prognosis with overall survival of only 8.3 months. The molecular alterations of HSC are also not well understood. In this study, the authors describe a patient who presented with a large liver mass. The patient underwent complete surgical resection and histological examination demonstrated HSC, infiltrating the stomach. PD-L1 was strongly positive in the tumor cells. The patient was started on anti-PD-L1 immunotherapy postsurgery and is doing well 15 months after surgical resection. Tumor whole exome sequencing revealed genetic alterations in , and genes, indicating their potential role in tumor development. - Source: PubMed
Publication date: 2024/02/16
Radhakrishnan SubathraMartin Catherine AnnVij MukulSubbiah KomalavalliRaju Lexmi PriyaGowrishankar GowripriyaVeldore Vidya HariniKaliamoorthy IlankumaranRammohan AshwinRela Mohamed - Autism spectrum disorder (ASD), Tourette syndrome (TS), and attention-deficit/hyperactivity disorder (ADHD) display strong male sex bias, due to a combination of genetic and biological factors, as well as selective ascertainment. While the hemizygous nature of chromosome X (Chr X) in males has long been postulated as a key point of "male vulnerability", rare genetic variation on this chromosome has not been systematically characterized in large-scale whole exome sequencing studies of "idiopathic" ASD, TS, and ADHD. Here, we take advantage of informative recombinations in simplex ASD families to pinpoint risk-enriched regions on Chr X, within which rare maternally-inherited damaging variants carry substantial risk in males with ASD. We then apply a modified transmission disequilibrium test to 13,052 ASD probands and identify a novel high confidence ASD risk gene at exome-wide significance (MAGEC3). Finally, we observe that rare damaging variants within these risk regions carry similar effect sizes in males with TS or ADHD, further clarifying genetic mechanisms underlying male vulnerability in multiple neurodevelopmental disorders that can be exploited for systematic gene discovery. - Source: PubMed
Publication date: 2023/12/06
Wang ShengWang BelindaDrury VanessaDrake SamSun NaweiAlkhairo HasanArbelaez JuanDuhn Clif Bal Vanessa HLangley KateMartin JoannaHoekstra Pieter JDietrich AndreaXing JinchuanHeiman Gary ATischfield Jay AFernandez Thomas VOwen Michael JO'Donovan Michael CThapar AnitaState Matthew WWillsey A Jeremy - Gastric cancer is a worldwide life-threatening cancer. The underlying cause of it is still unknown. We have noticed that some cancer/testis antigens (CTAs) are up-regulated in gastric cancer. The role of these genes in gastric cancer development is not fully understood. The main aim of the current study was to comprehensively investigate CTAs' expression and function in stomach adenocarcinoma (STAD). - Source: PubMed
Publication date: 2023/02/25
Ansari SaraNikpour Parvaneh