Ask about this productRelated genes to: LNX1 antibody
- Gene:
- LNX1 NIH gene
- Name:
- ligand of numb-protein X 1
- Previous symbol:
- LNX
- Synonyms:
- MPDZ, PDZRN2
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-31
- Date modifiied:
- 2016-04-05
Related products to: LNX1 antibody
Related articles to: LNX1 antibody
- Enamel formation comprises two main stages: matrix formation (secretory), during which ameloblasts secrete an immature enamel matrix; and maturation, during which the matrix is degraded and remodeled. During maturation, the position of the cellular tight junctions change between the ruffle- and smooth-end phases; however, the regulatory mechanisms underlying this morphological alteration remain unclear. We focused on the Ligand of Numb-protein X (LNX): We would like to delete " family of proteins" and add "PDZ-domain containig" to define the LNXs have ability to bind tight junctional proteins, which have been identified as PDZ-domain containing E3 ubiquitin ligases, and examined the changes in their expression and localization in ameloblasts. - Source: PubMed
Publication date: 2026/02/06
Sugimoto TakumiMatsuki-Fukushima MiwakoNitta MasakazuFunatsu TakahiroNonaka Naoko - The rapid increase in the incidence of Alzheimer's disease (AD) has raised concerns, given its profound effects on both society and the economy. Despite extensive research efforts in this area, there are no existing treatments that have the ability to change the progression of the disease. - Source: PubMed
Publication date: 2025/10/30
Wang XiaomingLiu YuanchengFu JuncaiLi YizhaoZhao MengyingTian Qing - Lip squamous cell carcinomas (SCC) often arise from actinic cheilitis. However, the factors driving oncogenic transformation and determinants of lip SCC differentiation are unclear. This study investigated the differences between lip SCC and premalignant actinic cheilitis and factors related to tumor differentiation. We included patients who received biopsies for actinic cheilitis that later progressed to lip SCC. Moreover, well-differentiated lip SCC and moderately-to-poorly differentiated lip SCC were selected for spatial transcriptomic analysis, using pan-cytokeratin and CD45 as morphology markers. In pan-cytokeratin-positive tumor areas, we detected 5 upregulated differentially expressed genes (KLK13, MGST1, LNX1, NDRGZ, and HMOX1) and 1 downregulated differentially expressed gene (HOXD11) in lip SCCs compared with those in premalignant lesions. Endosomal transport, lysosomal transport, macroautophagy, and wound-healing pathways were significantly upregulated in lip SCC compared with those in actinic cheilitis. Furthermore, proteolysis- and hypoxia-related differentially expressed genes were found in moderately-to-poorly differentiated lip SCC compared with those in well-differentiated lip SCC. General cancer-associated fibroblast markers (P = .021) were increased in actinic cheilitis preceding moderately-to-poorly differentiated lip SCCs compared with those in actinic cheilitis preceding well-differentiated lip SCCs, which was validated in immunohistochemical staining. This observation could expand our understanding of the changes in the microenvironment composition during lip SCC carcinogenesis and according to lip SCC differentiation. - Source: PubMed
Publication date: 2025/05/27
Choi Myoung EunYang Hee JooJung Joon MinLee Woo JinLee Mi WooWon Chong Hyun - One of the most common and prevalent cancers is laryngeal squamous cell carcinoma (LSCC), which poses a great threat to the life and health of the patient. Nonetheless, it has been demonstrated that ubiquitination is crucial for the development and course of LSCC. Therefore, it is particularly important to identify biomarkers for ubiquitination-related genes (UbRGs) in LSCC. - Source: PubMed
Publication date: 2025/05/12
Chen QiuWu ZhiminMa Yifei - Prostate cancer (PCa) is the most frequently diagnosed cancer in men and a leading cause of cancer-related death. While prostate-specific antigen is a widely used biomarker, its specificity is limited. This study investigated the prognostic significance of gene subsets associated with the ubiquitin-proteasome pathway in PCa. - Source: PubMed
Takashima YasuoYoshii KengoTanaka MasamiTashiro Kei