Ask about this productRelated genes to: LILRA5 antibody
- Gene:
- LILRA5 NIH gene
- Name:
- leukocyte immunoglobulin like receptor A5
- Previous symbol:
- LILRB7
- Synonyms:
- ILT11, LIR9, CD85, CD85f
- Chromosome:
- 19q13.42
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-14
- Date modifiied:
- 2016-10-05
Related products to: LILRA5 antibody
Related articles to: LILRA5 antibody
- Risk of cardiorenal complications varies among patients with type 2 diabetes (T2D). T2D pathway-specific polygenic risk scores (psPRS) capture genetic susceptibility related to distinct intermediate biological processes associated with T2D and cardiorenal outcomes, predominantly in European populations. Their relevance in multi-ethnic Asian populations remains unclear. We explored associations between T2D-derived psPRS and cardiorenal outcomes and circulating proteins linked to cardiorenal complications. - Source: PubMed
Publication date: 2026/04/08
Gurung Resham LZheng HuiliTan Jia Le IvanLiu SylviaLiu Jian-JunAng KevenSubramaniam TavintharanSum Chee FangLim Su Chi - Earlier research observed the effects of plasma proteins on ischemic stroke (IS). This Mendelian randomization (MR), in vivo study additionally assesses the associations of localized populations of plasma proteins with IS to further confirm the causality and explore drug targets. - Source: PubMed
Publication date: 2026/03/17
Ren HaoxuDing YingyueWang RuonanLi JinjianYang ChenganWang XuZhao Dexi - This study aims to explore the correlation between Osteoporosis and stroke risk, and find potential common key genes and drugs for intervention through bioinformatics methods. - Source: PubMed
Publication date: 2025/12/11
Ren WeiminShu WenHuang ShuzhongQin YufeiHu JuanShi Zhanying - Inflammation is a key driver of Alzheimer's disease (AD) and may connect all known AD risk factors. Recently, AD resilience outcomes have been developed which have helped to uncover mechanisms that enable some individuals to withstand significant AD pathology or genetic risk, while retaining cognitive function. We conducted a series of transcriptome-wide association studies (TWAS) focusing on monocytes, key innate immune cells that respond to pathogens and invade the CNS. Monocyte expression data under various immune stimulation states (naive, LPS 2 h, LPS 24 h, IFN 24 h) and corresponding genotype data from 432 individuals (Fairfax et al. [1]) were analyzed. We developed cis-genetic expression models using both elastic-net, and MASH combined with LD-pruning; capturing polygenic structures and independent inflammatory eQTLs across conditions, respectively. These models were applied to GWAS summary statistics of three AD resilience phenotypes: cognitive and global AD-resilience, and Amish cognitive preservation. We identified 180 TWAS results surpassing a suggestive significance threshold of P < 0.20, including 92 unique genes. APP, a well-known AD gene, showed the strongest overall association, which may inform ongoing efforts targeting its action in the brain. Whole-blood RNA-seq data from a separate AD cohort confirmed differential expression between AD cases and controls in 35 putative targets, including: SURF1, ACKR3, LILRA5, FBXO2, ITPR1, and HRH4. We also demonstrate that the regulation of these genes is specific to monocytes. Finally, in-silico cell sorting (CIBERSORTx) revealed differential monocyte abundance by AD status, supporting monocyte-driven inflammation as a distinct, complementary pathway of myeloid cell involvement in AD. Together, these findings highlight monocytes as a critical and understudied cellular component for AD resilience mechanisms, with potential implications for novel immunotherapeutic strategies and precision medicine approaches in AD. - Source: PubMed
Publication date: 2025/11/18
Mustafa YousefMain Leighanne RMews MakaelaJanve Vaibhav AHohman Timothy JHaines Jonathan LSong Yeunjoo EGriswold Anthony JPericak-Vance Margaret AScott William KNaj Adam CBelow Jennifer EDumitrescu LoganBush William S - Activating immune receptors provides mechanisms for phagocytes to elicit important effector functions that promote the killing of microbes. Leukocyte immunoglobulin-like receptor A5 (LILRA5), an orphan immune receptor expressed by human phagocytes and co-localising with FcRγ, remains poorly characterised. To address this, we developed a highly specific anti-LILRA5 monoclonal antibody that has agonistic properties. We show LILRA5 expression on naïve monocytes and neutrophils, and that ligation of LILRA5 stimulates ROS production. While increased LILRA5 transcripts have been associated with sepsis, we also observed increased levels in patients with systemic infection but without sepsis complications. Ex vivo bacterial infection of whole blood did not alter surface LILRA5 expression, but LPS stimulation changed expression levels, indicating that surface LILRA5 expression is dynamic and likely regulated post-transcriptionally, changing responses to different stimuli or over time. Soluble (s)LILRA5 was enhanced in sera from sepsis patients and in supernatants of monocytes that were LPS-stimulated, indicating that shedding of LILRA5 from cell surfaces or that expression of sLILRA5 isoforms provides a mechanism to regulate surface LILRA5 expression levels. Finally, we show that altered surface LILRA5 expression influences LILRA5-induced ROS production capacity. Thus, LILRA5 is a dynamically regulated activating receptor expressed on phagocytes that stimulates ROS production. - Source: PubMed
Fu ZuyiRumpret MatevžKube-Golovin IrinaLyndin MykolaSolntceva VeraZhao YuxiKonieva AnastasiaLiu NaPress Adrian TFlohé Stefanie BBauer MichaelWennemuth GuntherSinger Bernhard BMcCarthy Alex J