Ask about this productRelated genes to: LGI3 antibody
- Gene:
- LGI3 NIH gene
- Name:
- leucine rich repeat LGI family member 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-30
- Date modifiied:
- 2016-10-05
Related products to: LGI3 antibody
Related articles to: LGI3 antibody
- MYCN non-amplified (MYCN-NA) neuroblastoma (NB) demonstrates considerable heterogeneity in both biological and clinical aspects, and its molecular and biological characteristics remain inadequately defined. - Source: PubMed
Publication date: 2026/04/28
Liu ShanWang ZhihongShen JianzhenLi LizhiLin Yaobin - We investigated the role of Lgi3-4 proteins in cardiac electrophysiology, with a specific focus on IKur, and their potential contribution to the pathophysiology of atrial fibrillation (AF). - Source: PubMed
Publication date: 2026/03/19
Socuéllamos Paula GMacías Álvarode Benito-Bueno ÁngelaCruz Francisco MRedondo-Moya MaríaCoronado María JoséRamil ElviraRosado SilviaRios-Rosado Elsa CarolinaValencia-Avezuela MaríaAndrés-Delgado LauraBlázquez José AntonioForteza-Gil AlbertoGutiérrez-Rodríguez MartaJalife JoséValenzuela Carmen - Transcription factor binding to IGHM enhancer 3-rearranged renal cell carcinoma (TFE3-RCC) is characterized by its aggressive nature, limited treatment options, and poor prognosis. However, the downstream targets of TFE3 fusion protein responsible for its tumorigenesis and progression remain unclear. Here, we demonstrated that leucine-rich repeat LGI family member 3 (LGI3) is a direct target of TFE3 fusion protein. TFE3 fusion protein can bind to the promoter of LGI3 and then activate its transcription. Importantly, LGI3 contributes to the proliferation, migration, and invasion of TFE3-RCC. Mechanistically, LGI3 interacts with gem nuclear organelle-associated protein 6 (GEMIN6) and inhibits its degradation via decreasing its ubiquitination. GEMIN6 upregulation promotes the mRNA maturation of Aurora B kinase (AURKB), thereby promoting the progression of TFE3-RCC. Importantly, drugs targeting GEMIN6 or AURKB significantly suppressed the growth of TFE3-RCC cells and organoids. In human TFE3-RCC tissues, LGI3 is highly expressed and positively correlated with GEMIN6 and AURKB. Overall, we revealed a novel mechanism underlying the progression of TFE3-RCC and provided potential new therapeutic targets. - Source: PubMed
Publication date: 2025/08/23
Liu JunxiaoFeng HuayiXiong ZhuangCao ShouqingCai TianweiWei WenjieTao WenZhang XuMa XinLi Xiubin - The brain extracellular matrix (ECM) regulates myelin repair and regeneration following a demyelinating event by interacting with neuronal progenitors and immune cells. Therefore, generation and characterization of decellularized human brain tissue (DHBT) in regions with distinct neuroregenerative capacities are essential to determine factors modulating the cellular regenerative behavior. We have established an effective decellularization protocol for the human neural stem cell (NSC)-rich subventricular zone (SVZ) as well as, frontal cortex (FC) and white matter (WM), and defined region-specific matrisomes with comparative proteomics. Subsequently, as proof-of-concept, survival and differentiation of NSCs and monocytes within the DHBT were investigated. The proteomic analysis of the DHBT confirmed the retention of matrisome proteins such as COL4A1, FBB, NCAN, ANXA2. Unique to the SVZ were LGI3 and C1QB, while annexins, S100A and TGM2 were found in FC; S100B was exclusive to the WM. NSCs cultured within WM and FC acquired an astrocytic phenotype, but both astrocytic and oligodendrocytic phenotypes were promoted by the SVZ DHBT. Moreover, imaging mass cytometry analysis indicated an anti-inflammatory phenotype differentiation of monocytes seeded on SVZ and WM. Thus, the established model is suitable for investigation of ECM properties and assessment of cell-matrix interactions. - Source: PubMed
Publication date: 2025/06/05
Bueno Roemel JeusepFernández-Zapata CamilaSalla MarenCampo Garcia JulianaAlacam AylinKlein OliverBöttcher ChotimaRadbruch HelenaPaul FriedemannStarossom Sarah CSilva Rafaela VInfante-Duarte Carmen - This study explored virulence genes, antibiotic resistance genes, and mobile genetic elements in 14 strains from milk and dairy products collected from different regions of Ethiopia. The strains were classified into two Multilocus Sequence Typing sequence types (ST2 and ST45) and further grouped into clonal complexes (CC2) and different cgMLST types. Twenty-nine virulence genes were identified across all 14 strains, with detected at higher levels in all strains except SAMN28661660. All strains also carried four antibiotic resistance genes (, , , ), contributing to their ability to withstand multiple antimicrobial agents. Notably, no plasmids or mobile genetic elements were detected. Stress resistance genes, including (), , and , were identified in all strains. However, genes encoding for disinfectant resistance were not identified from all strains. LGI-2 was found in all the strains and none of the studied strains harbored LGI-1 and LGI-3. Conserved CRISPR-Cas systems were found in some strains. KEGG pathway analysis revealed that and genes facilitate bacterial internalization through host actin polymerization. Overall, the study provided crucial insights into the genomic features of in the Ethiopian dairy chain. It is crucial to establish continuous monitoring of in dairy products, improve sanitation, enforce stricter antibiotic usage and food safety regulations, and raise public awareness of associated risks. - Source: PubMed
Publication date: 2025/04/16
Kinde Mebrie ZemeneKerisew BizuayehuEshetu TegegneGessese Abebe Tesfaye