Ask about this productRelated genes to: LGI3 antibody
- Gene:
- LGI3 NIH gene
- Name:
- leucine rich repeat LGI family member 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-30
- Date modifiied:
- 2016-10-05
Related products to: LGI3 antibody
Related articles to: LGI3 antibody
- Listeria monocytogenes is a major foodborne pathogen found in outdoors, wild and domesticated animals, food-processing environments and food products. Genomic studies have mainly focused on strains from clinical or food-associated sources, but other reservoirs have been mostly underexplored. We performed in-depth phylogenetic and pangenome analyses of 371 L. monocytogenes strains isolated along the pig manure management chain, from living pigs to treated manure. Chromosome and plasmid-related virulence and resistance markers were thoroughly examined. Genomic islands along with mobile genetic elements were characterized. Anaerobic digestion and nitrification-denitrification treatments did not significantly impact the clonal diversity. We identified a novel Listeria Genomic Island 3 (LGI3) variant carrying a new internalin gene in 46 strains of Clonal Complex CC77. Chromosomal resistance to tetracycline was found in 7% of strains, linked to one Tn5801 and four distinct Tn916 acquisition events. In total, 100 plasmids were identified and characterized, including several multi-heavy metal resistance plasmids and one associated with multidrug antibiotic resistance. We characterized a large diversity of 932 prophages integrated across 10 chromosomal sites. This study provides innovative genomic insights into L. monocytogenes populations within the pig manure value chain and highlights potential routes of transmission between pig, farm environment and humans. - Source: PubMed
Publication date: 2026/06/24
Lagarde JeanRoussel SophieDenis MartineBoscher EvelynePiveteau PascalDouarre Pierre-Emmanuel - MYCN non-amplified (MYCN-NA) neuroblastoma (NB) demonstrates considerable heterogeneity in both biological and clinical aspects, and its molecular and biological characteristics remain inadequately defined. - Source: PubMed
Publication date: 2026/04/28
Liu ShanWang ZhihongShen JianzhenLi LizhiLin Yaobin - - Source: PubMed
Ravens UrsulaCoté AnthonyPeyronnet Rémi - We investigated the role of Lgi3-4 proteins in cardiac electrophysiology, with a specific focus on IKur, and their potential contribution to the pathophysiology of atrial fibrillation (AF). - Source: PubMed
Socuéllamos Paula GMacías Álvarode Benito-Bueno ÁngelaCruz Francisco MRedondo-Moya MaríaCoronado María JoséRamil ElviraRosado SilviaRios-Rosado Elsa CarolinaValencia-Avezuela MaríaAndrés-Delgado LauraBlázquez José AntonioForteza-Gil AlbertoGutiérrez-Rodríguez MartaJalife JoséValenzuela Carmen - Transcription factor binding to IGHM enhancer 3-rearranged renal cell carcinoma (TFE3-RCC) is characterized by its aggressive nature, limited treatment options, and poor prognosis. However, the downstream targets of TFE3 fusion protein responsible for its tumorigenesis and progression remain unclear. Here, we demonstrated that leucine-rich repeat LGI family member 3 (LGI3) is a direct target of TFE3 fusion protein. TFE3 fusion protein can bind to the promoter of LGI3 and then activate its transcription. Importantly, LGI3 contributes to the proliferation, migration, and invasion of TFE3-RCC. Mechanistically, LGI3 interacts with gem nuclear organelle-associated protein 6 (GEMIN6) and inhibits its degradation via decreasing its ubiquitination. GEMIN6 upregulation promotes the mRNA maturation of Aurora B kinase (AURKB), thereby promoting the progression of TFE3-RCC. Importantly, drugs targeting GEMIN6 or AURKB significantly suppressed the growth of TFE3-RCC cells and organoids. In human TFE3-RCC tissues, LGI3 is highly expressed and positively correlated with GEMIN6 and AURKB. Overall, we revealed a novel mechanism underlying the progression of TFE3-RCC and provided potential new therapeutic targets. - Source: PubMed
Publication date: 2025/08/23
Liu JunxiaoFeng HuayiXiong ZhuangCao ShouqingCai TianweiWei WenjieTao WenZhang XuMa XinLi Xiubin