Ask about this productRelated genes to: LGI2 antibody
- Gene:
- LGI2 NIH gene
- Name:
- leucine rich repeat LGI family member 2
- Previous symbol:
- -
- Synonyms:
- KIAA1916, FLJ10675
- Chromosome:
- 4p15.2
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-30
- Date modifiied:
- 2016-10-05
Related products to: LGI2 antibody
Related articles to: LGI2 antibody
- Genetic variants affecting brain development can lead to an increased risk of neurological disorders later in life. A protein-truncating variant in a gene for secreted neural protein LGI2 (Leucine-rich glioma-inactivated 2) is associated with remitting focal juvenile epilepsy and later behavioural disorders in Lagotto Romagnolo dogs. Yet, the developmental expression pattern of LGI2 in the brain and its association with neuronal network activities and behaviour have not been characterized. Here we show that Lgi2 gene expression is low in the neonatal mouse hippocampus but increases during juvenility (P14). Lgi2 is mainly expressed in GABAergic interneurons. Electrophysiological recordings using hippocampal slice cultures from LGI2 deficient mice revealed that Lgi2 ablation provokes ictal-like activity. We also found that adult LGI2-deficient mice have deficits in spatial reversal learning and impaired cognitive flexibility, thus paralleling Lagottos' behavioural ailments with ADHD-like symptoms. Therefore, our mouse model reveals functional defects in developing LGI2 deficient networks that associate with neurological disorders manifesting later in life. - Source: PubMed
Publication date: 2025/11/01
Savonlehto TiinaNevalainen ElisaKukko-Lukjanov Tiina-KaisaHytönen Marjo KSeppälä EijaSegerstråle MikaelPartanen JuhaLauri Sari ELohi HannesTaira Tomi - Growth traits are crucial for the economic viability in broiler production, as they significantly contribute to the cost of rearing. Maximizing body weight (BW) while minimizing feed intake is key to enhancing the efficiency of broiler breeding. Identifying the genetic architecture associated with BW trait is therefore a critical step in enhancing breeding strategies. - Source: PubMed
Publication date: 2025/05/20
Luo NaCai KeqiWei LiminCui HuanxianWen JieAn BingxingZhao Guiping - This study explored virulence genes, antibiotic resistance genes, and mobile genetic elements in 14 strains from milk and dairy products collected from different regions of Ethiopia. The strains were classified into two Multilocus Sequence Typing sequence types (ST2 and ST45) and further grouped into clonal complexes (CC2) and different cgMLST types. Twenty-nine virulence genes were identified across all 14 strains, with detected at higher levels in all strains except SAMN28661660. All strains also carried four antibiotic resistance genes (, , , ), contributing to their ability to withstand multiple antimicrobial agents. Notably, no plasmids or mobile genetic elements were detected. Stress resistance genes, including (), , and , were identified in all strains. However, genes encoding for disinfectant resistance were not identified from all strains. LGI-2 was found in all the strains and none of the studied strains harbored LGI-1 and LGI-3. Conserved CRISPR-Cas systems were found in some strains. KEGG pathway analysis revealed that and genes facilitate bacterial internalization through host actin polymerization. Overall, the study provided crucial insights into the genomic features of in the Ethiopian dairy chain. It is crucial to establish continuous monitoring of in dairy products, improve sanitation, enforce stricter antibiotic usage and food safety regulations, and raise public awareness of associated risks. - Source: PubMed
Publication date: 2025/04/16
Kinde Mebrie ZemeneKerisew BizuayehuEshetu TegegneGessese Abebe Tesfaye - Listeria monocytogenes is a foodborne pathogen that causes human listeriosis and may be transmitted to humans via the food chain, beginning at slaughter and extending through food production and consumption. In this study, we performed whole-genome sequencing (WGS) analysis to determine the genetic characteristics of L. monocytogenes from the carcasses and environments of cattle and pig slaughterhouses in Korea. In total, 50 L. monocytogenes isolates were collected from 46 cattle and 47 pig slaughterhouses nationwide from 2014 to 2022. They were classified into two lineages, 12 sublineages, 12 sequence types, 11 clonal complexes (CCs), and 15 core-genome multilocus sequence types. L. monocytogenes isolates were divided into two lineages: lineage I (serotypes 1/2b and 4b) and lineage II (serotypes 1/2a and 1/2c). The most frequent CCs were CC9 (46.0 %), followed by CC224 (16.0 %) and CC155 (14.0 %). Although all isolates exhibited highly conserved LIPI-1, 20.0 % and 2.0 % contained LIPI-3 or LIPI-4, respectively. Moreover, 96.0 % of the isolates had full-length inlA. Interestingly, 21 of the 23 CC9 isolates contained mutations in inlA resulting from premature stop codon (PMSC). The mdrL and Listeria genomic island-2 (LGI-2) were identified in all L. monocytogenes isolates, whereas LGI-3 was identified in 32.0 % of the isolates. The L. monocytogenes isolates contained various antimicrobial resistance genes, moreover, the plasmid-borne resistance genes tetM and mprF were also identified in 34.0 % and 100 % of the isolates, respectively. Twenty-four isolates (48.0 %) harbored one or two plasmids (pLM33, DOp1, pLGUG1, and pLM5578), and 29 isolates (58.0 %) harbored at least one insertion sequence, composite transposon, and integrative conjugative element. Four isolates showed two CRISPR-Cas types IB and II-A. In addition, phage sequences associated with the spacer constituting the CRISPR array were identified in 26 Listeria phages from 14 L. monocytogenes isolates. The genetic composition of L. monocytogenes was conserved in a collinearity relationship between each of the five L. monocytogenes isolates from the cattle and pig slaughterhouses. These findings suggest that L. monocytogenes isolated from cattle and pig slaughterhouses have the ability to cause human disease and exhibit virulent characteristics. - Source: PubMed
Publication date: 2025/03/09
Hong SerimMoon Jin-SanLee Young JuKim Ha-Young - Brain function relies on the generation of a large variety of morphologically and functionally diverse, but specific, neuronal synapses. Here we show that, in mice, the initial formation of synapses on cerebellar Purkinje cells involves a presynaptic protein-CBLN1, a member of the C1q protein family-that is secreted by all types of excitatory inputs. The molecular program then evolves only in one of the Purkinje cell inputs, the inferior olivary neurons, with the additional expression of the presynaptic secreted proteins C1QL1, CRTAC1 and LGI2. These molecules work in concert to specify the mature connectivity pattern on the Purkinje cell target. These results show that some inputs actively and gradually specify their synaptic molecular identity, while others rely on the 'original molecular code'. Thus, the molecular specification of excitatory synapses, crucial for proper circuit function, is acquired in a stepwise manner during mouse postnatal development and obeys input-specific rules. - Source: PubMed
Publication date: 2024/12/10
Paul Maëla ASigoillot Séverine MMarti LéaUrra Quiroz Francisco JDelagrange MarineCheung Hiu WMartinelli David COriol ElieHakim VincentMailly PhilippeSelimi Fekrije