Ask about this productRelated genes to: LGALS9 antibody
- Gene:
- LGALS9 NIH gene
- Name:
- galectin 9
- Previous symbol:
- -
- Synonyms:
- LGALS9A
- Chromosome:
- 17q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-06-25
- Date modifiied:
- 2016-05-13
Related products to: LGALS9 antibody
Related articles to: LGALS9 antibody
- Zinc (Zn)-based metals have been considered as promising materials for bone regeneration and repair. Neutrophils, as the initial responders in the acute inflammatory phase, play a critical role by generating specialized mediators that facilitate the natural resolution of inflammation. Nevertheless, the mechanisms governing neutrophil-driven inflammation following the implantation of Zn-based metals are not fully elucidated. This study investigated neutrophil-macrophage crosstalk around Zn-based implants using single-cell transcriptomic profiling. A high-resolution cellular atlas of the peri-implant bone marrow microenvironment was generated in a rat femoral model comparing Zn-based implants with the titanium (Ti) ones. The results revealed that Zn implants induced a distinct neutrophil (Neu) subset heterogeneity, including Cd177 Neu, Ifit1bl Neu, RatNP-3b Neu, and Prtn3 Neu, the latter demonstrating enhanced tissue repair ability through osteoclast differentiation pathways. Zn-based metallic implants reduced macrophage (Mac) reactivity and promoted Hp Mac dominance compared to Ti implants, which showed higher Apoe Mac proportions. Crosstalk analysis identified a significant interaction between the neutrophil subset Ifit1bl Neu and the macrophage subset Eno3 Mac under Zn implantation, mediated by the Lgals9-Ighm ligand-receptor axis. These findings suggested that degradation products of Zn-based implants modulated immune cell differentiation and interaction networks, thereby modulating biological response. - Source: PubMed
Publication date: 2026/07/14
Du MiYan QinyangZhu ChenLi AnChen JiahaoLiang HuibinZhou JiannanLi PingDai Jingtao - Ferroptosis is an iron-dependent programmed cell death, which plays a complex role in pancreatic ductal adenocarcinoma (PDAC), regulating both tumor development and immune interaction. However, the clinical significance and potential molecular mechanism of ferroptosis in PDAC have not been fully clarified, which limits its application in treatment. - Source: PubMed
Publication date: 2026/07/13
Liu WeiShen YifenRao LiQiao ZhenguoLing XinCheng LongShen Genhai - The multifaceted oncogenic role of teratocarcinoma-derived growth factor 1 (TDGF1) in colon cancer remains incompletely understood. Through integrative bioinformatic and functional analyses, we identified a novel competing endogenous RNA (ceRNA) axis wherein the long non-coding RNA OLMALINC directly sponges hsa-miR-3614-5p, leading to the derepression of TDGF1. This OLMALINC/miR-3614-5p/TDGF1 axis promoted colon cancer cell proliferation, migration, invasion, and anti-apoptosis in vitro, whereas TDGF1 knockdown significantly suppressed tumor growth in vivo. Mechanistically, TDGF1 co-activated oncogenic signaling via the Thr88-dependent Nodal/Smad2 cascade and the Glypican-1-mediated MAPK/AKT pathway. Beyond cell-autonomous effects, transcriptomic and single-cell analyses revealed that elevated TDGF1 correlates with an immunosuppressive microenvironment, characterized by reduced immune infiltration and altered LGALS9-CD44 malignant-T cell communication. Clinically, high TDGF1 expression in a tissue microarray cohort was significantly associated with advanced T stage, reduced expression of specific mismatch repair proteins (MLH1/PMS2), and poor overall survival. Collectively, this study delineates the OLMALINC/miR-3614-5p/TDGF1 regulatory circuit and establishes TDGF1 as a multifaceted driver of tumor progression, highlighting its potential as a prognostic biomarker and therapeutic target in colon cancer. - Source: PubMed
Publication date: 2026/06/23
Gao FengLi XiaoliLi JiaweiYang ShuoZhang BoyuSun YingZheng LihuaWang GuannanLiu LeiBao YongliYang Xiaoguang - Tumor-associated macrophages (TAMs) play a crucial role in colorectal cancer (CRC) metastasis, particularly in the establishment of the liver metastatic niche. TAMs facilitate metastasis by enabling epithelial-mesenchymal transition (EMT) and suppressing anti-tumor immunity. While their roles in primary tumors have been extensively investigated, their functions at metastatic sites remain poorly understood. In this study, we analyzed the single-cell RNA sequencing data from 46 CRC patients, encompassing 402,972 cells, to identify macrophage subsets associated with liver metastasis. A distinct population of APOC1 IFI30 TAMs was identified and found to be significantly enriched in metastatic liver lesions. Compared to primary tumors (PT), the number of APOC1 IFI30 TAMs significantly increased at liver metastatic sites after CRC cells metastasized to the liver. We employed spatial transcriptomics to validate the above conclusions. These TAMs exhibited significantly enhanced immunosuppressive capacity and cholesterol synthesis metabolism. Further investigation showed that TAMs within metastatic niches reprogram the mevalonate pathway to enhance cholesterol synthesis, characterized by upregulation of key genes such as HMGCR and ACAT1/2. These TAMs act on surrounding tumor cells by secreting cholesterol and cytokines such as TNFSF12, TGFB1, MIF and LGALS9, thereby enhancing tumor adhesion and proliferation and creating an immunosuppressive microenvironment to continuously support tumor growth. Our findings provided new insights into the complex interactions among TAMs, immune cells, and tumor cells within CRC metastatic microenvironment, highlighting potential therapeutic targets to disrupt TAMs-mediated immune evasion and metastatic progression. - Source: PubMed
Publication date: 2026/07/11
Cai ZheyouChen YibingCui LeiYao JineQiao JianghuaSun WeihongLiu HaishengYang LinhaoYang ZhuangLiu QuentinHou BenxinZou ZhengzhiLai Dongming - Pyroptosis is a significant contributor to the development of severe acute pancreatitis (SAP), and the presence of SAP together with a reduced platelet count often indicates a poor prognosis. In this study, we screened targets from platelets and explored the role of lectin galactoside-binding soluble 9 (LGALS9) in acinar cell pyroptosis and inflammation in SAP. - Source: PubMed
Publication date: 2026/07/03
Xiao WangXu XingdaYang TingkangZou XiangsenXu HaoZhang HanyaQian JianpingWu FengWang LipingZhou LeiGan ZheZhang GuoweiLi Chuanjiang