Ask about this productRelated genes to: LASP1 antibody
- Gene:
- LASP1 NIH gene
- Name:
- LIM and SH3 protein 1
- Previous symbol:
- -
- Synonyms:
- MLN50, Lasp-1
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1997-05-22
- Date modifiied:
- 2016-10-05
Related products to: LASP1 antibody
Related articles to: LASP1 antibody
- The Jersey-yak, a hybrid offspring of Jersey cattle and yak, exhibits characteristics such as strong adaptability, rapid growth and development, and outstanding production performance. Therefore, Jersey-yaks were fed diets with different crude protein (CP) levels (0%, 15.16%, and 17.90% CP, respectively), and the regulatory mechanisms underlying their growth and development were elucidated. - Source: PubMed
Publication date: 2026/08/19
Yang GuowuMa BinLa YongfuMa XiaomingWu XiaoyunChu MinGuo XianWang LeiLiang Chunnian - A substantial amount of research has been dedicated to the mechanisms by which tumor cells evade immune system recognition and manipulate the immune microenvironment to facilitate immune escape. Recent studies have shown that viruses and tumors can protect themselves from immune cytotoxicity by remodeling the actin cytoskeleton. However, cytoskeleton-mediated immune resistance and the specific cytoskeleton-related proteins involved require further research. - Source: PubMed
Publication date: 2026/09/02
Zhang TemingSun YingyingChen ChaoZheng JingweiChang LiyunXiang YizhenZhang QiongyingLi HaoliangXie WangkaiXu QiaoyiMao ChenchenLu MingdongCai ZhenzhaiShen XianXue XiangyangHan Zheng - The current study investigated the correlation between Transient Receptor Potential (TRP)-related Genes (TRGs), prognosis, and drug sensitivity in Osteosarcoma (OS). - Source: PubMed
Publication date: 2026/07/07
Li XiangmingZhang MinghangXu ZiyiWang WeizhengLi Penghui - LIM and SH3 protein 1 (LASP1) is a widely expressed scaffold protein associated with actin-rich structures. In Lasp1-knockout mice, reproductive defects such as longer intervals between litters and reduced pup numbers were observed. Consistently, data from the Human Protein Atlas show strong LASP1 expression in spermatids, suggesting a reproductive role. Mammalian fertilization involves sequential processes of sperm activation, capacitation, and acrosome reaction, driven by bicarbonate-mediated PKA activation, CNP-regulated PKG stimulation, F-actin polymerization, Ca-signaling, and MAPK signaling pathways - culminating in membrane fusion and CD44 cluster formation for interaction with the egg. In this context, we observed differential isoform expression of PKG in human and mice. Our data provide the first evidence of LASP1 presence in the head, midpiece, and tail of human and mouse spermatozoa. During capacitation, LASP1 undergoes dynamic changes, co-localizes with F-actin and stabilizes the equatorial ring segment. In mice, loss of LASP1 did not affect sperm morphology, motility or chemotaxis, but led to changes in protein phosphorylation, incomplete capacitation, and reduced hyaluronan receptor surface expression, revealing a novel role of LASP1 in sperm fertilization. - Source: PubMed
Bender AliciaAndress KilianBoesl Michael RStaib ClaudiaWoehl-Wenigerkind AdrianeKneitz BurkhardBartolomaeus HendrikZernecke AlmaButt Elke - Functional validation of host factors in whole-animal models is a major bottleneck in virology; it hinders the translation of data from in vitro studies into a deeper understanding of the viral life cycle and pathogenesis. To address this challenge, we developed a systematic in vivo screening platform for influenza A virus. This platform comprises a library of 84 CRISPR-Cas9-generated gene-modified mouse lines targeting host factors prioritized from the literature and in vitro small interfering RNA (siRNA) screening studies. Using this resource, we identified 17 host factors whose genetic ablation conferred resistance to influenza A virus infection. Further studies of two of these factors, Arhgef28 and Lasp1, revealed distinct protective mechanisms against influenza A virus. We offer this mouse library to the research community as a powerful platform for studying virus-host interactions in a physiologically relevant context. - Source: PubMed
Publication date: 2026/06/16
Ueki HiroshiTomita YurikoDuong CalvinMitake HiromichiKiso MakiFurusawa YuriZhao Dongmingda Silva Lopes Tiago JoseWu LiFeng HuapengYamayoshi SeiyaFukuyama SatoshiYamashita MakotoOzawa ManabuIkawa MasahitoYoshida NobuakiWatanabe TokikoKawaoka Yoshihiro