Ask about this productRelated genes to: KRT6A antibody
- Gene:
- KRT6A NIH gene
- Name:
- keratin 6A
- Previous symbol:
- KRT6C, KRT6D
- Synonyms:
- CK6C, K6C, CK6D, K6D
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1991-09-12
- Date modifiied:
- 2019-04-23
Related products to: KRT6A antibody
Related articles to: KRT6A antibody
- Gemcitabine remains a cornerstone chemotherapy for pancreatic cancer, yet intrinsic and acquired resistance severely limits its efficacy. This study aimed to identify key drivers of gemcitabine resistance and develop a targeted strategy to restore chemosensitivity. - Source: PubMed
Publication date: 2026/04/17
Zhang JunfengWang XianxingZeng SilueTang BoYang XinyiXie ShaowenSun HaihanWang RuXia RenpeiLi JingheWang HuaizhiShi ZhitianGu JianyouWei Dong - Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by excessive keratinocyte proliferation, oxidative stress, and dysregulated cytokine signaling. Although topical corticosteroids remain the first-line therapy, their long-term use is often limited by adverse effects, highlighting the need for safer non-steroidal therapeutic alternatives. This study investigated the therapeutic efficacy and underlying mechanisms of a topical astaxanthin (AST) formulation in an imiquimod (IMQ)-induced mouse model of psoriasiform dermatitis. Following IMQ induction, mice were randomly assigned to vehicle, clobetasol, or AST treatment groups (0.5-1.5%) for 14 days. Disease progression was evaluated through biochemical analysis of oxidative stress biomarkers, including NADPH oxidase (NOX), malondialdehyde (MDA), nitric oxide (NO), and superoxide dismutase (SOD), as well as ELISA-based quantification of inflammatory cytokines (TNF-α, IL-6, IL-17, and IL-23). Histopathological changes were assessed using hematoxylin and eosin staining, while molecular alterations were examined by RT-qPCR analysis of psoriasis-associated keratin genes (Krt16, Krt17, and Krt6a) and evaluation of JAK-STAT signaling activity. AST treatment significantly suppressed the IL-23/IL-17 inflammatory axis, reduced NOX activity and lipid peroxidation, restored endogenous antioxidant defenses, and inhibited JAK-STAT signaling. These biochemical and molecular effects were accompanied by marked downregulation of keratin gene expression and substantial histological improvement, including normalization of epidermal thickness, reduced parakeratosis, and decreased inflammatory infiltration. Notably, high-dose AST demonstrated therapeutic efficacy comparable to, and in some parameters exceeding, that of clobetasol. Collectively, these findings indicate that topical astaxanthin exerts coordinated antioxidant, anti-inflammatory, and anti-proliferative effects, supporting its potential as a promising multi-target non-steroidal therapeutic candidate for psoriasis management. - Source: PubMed
Publication date: 2026/04/03
Albahadly Waleed Khaled YounisAl-Saedi Haider Falih ShamikhAshoor Jamal AliRasool Mohammed IbrahimHasan Samer AliALtrufi Meeqaat H - Human papillomavirus (HPV)-associated endocervical adenocarcinoma is the second-most common cancer of the uterine cervix. HPV-associated endocervical adenocarcinoma can be classified into histologic Silva patterns of invasion, which are associated with clinical outcome. However, the mechanisms underlying these patterns of invasion are incompletely understood. We used whole transcriptome spatial transcriptomics to examine gene expression differences separately in the tumor epithelium and the surrounding stromal immune microenvironment (SIME). Seven cases were evaluated, focusing on cases with two distinct patterns of invasion within the same tumor, to control for inter-patient heterogeneity. The most strongly upregulated pathways in both higher-risk tumor epithelium and SIME were associated with extracellular matrix (ECM) remodeling. Transcriptomic-based inference of immune cell populations showed an increase in macrophage populations in higher-risk tumor areas, confirmed by immunohistochemistry. Finally, we derived a four-gene signature from genes upregulated in higher-risk tumor epithelium ( and ), which was associated with worse clinical outcome in an independent dataset (The Cancer Genome Atlas). Overall, this work demonstrates that ECM remodeling and macrophage presence are important in the progression to high-risk patterns of invasion in HPV-associated endocervical adenocarcinoma. In addition, we established a prognostic four-gene signature that is predictive of poor outcome. - Source: PubMed
Publication date: 2026/03/12
Axelrod Margaret LZhou RuiwenSun Lulu - Despite extensive multi-omics studies on squamous cell carcinomas (SCCs) across different organs, the shared transcriptional regulatory mechanisms that driving SCC remain unclear. This study systematically identified common and distinct transcriptomic alterations in SCCs, highlighting key genes and pathways with prognostic and therapeutic relevance. By integrating large-scale gene expression data from SCC tumors and adjacent normal tissues, we revealed dysregulated gene expression patterns (DGEPs) and quantified their similarity across SCCs through correlation and regression analyses. Gene co-expression network analysis identified SCC-associated modules and hub genes, whose biological and clinical significance was further explored through subtype analysis and prognostic modeling. Our findings show that SCCs from the head and neck, esophagus, and cervix share highly similar DGEPs and regulatory networks, whereas lung and skin SCCs exhibit more distinct molecular characteristics. Key processes such as epithelial-mesenchymal transition, extracellular matrix remodeling, and immune-related pathways were strongly linked to SCC prognosis. Moreover, a six-gene prognostic signature (,,,,, and ) demonstrated robust predictive power for clinical outcomes and therapy response. These findings provide insights into SCC progression and potential therapeutic targets. - Source: PubMed
Publication date: 2026/03/10
Wang DankeLi XuZhou JiaqiYuan HuangboGao PeipeiLi YucanZeng YixinSuo ChenChen Xingdong - Epithelial remodeling is a key pathologic feature of eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP). Among the various remodeling patterns, squamous metaplasia remains an underrecognized component in eCRSwNP. - Source: PubMed
Publication date: 2026/02/26
Xie ShaobingJiang SijieZhang JunyiXie ZhihaiJiang WeihongZhang Hua