Ask about this productRelated genes to: KRT36 antibody
- Gene:
- KRT36 NIH gene
- Name:
- keratin 36
- Previous symbol:
- KRTHA6
- Synonyms:
- -
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-11
- Date modifiied:
- 2016-03-09
Related products to: KRT36 antibody
Related articles to: KRT36 antibody
- Our previous study demonstrated that CCL26 secreted by cancer-associated fibroblasts (CAF) promoted the invasive phenotype of oral squamous cell carcinoma (OSCC), however, more comprehensive clinical expression patterns of CCL26 and its role in immunotherapy remains ambiguous. - Source: PubMed
Publication date: 2025/01/27
Liu LingyunGuan ShuoXue YizhuoHe YijiaDing LiangFu YongChen ShengWang ZhiyongWang Yi - Ubiquitination is the most common post-translational modification and is essential for various cellular regulatory processes. RNF187, which is known as RING domain AP1 coactivator-1, is a member of the RING finger family. RNF187 can promote the proliferation and migration of various tumor cells. However, whether it has a similar role in regulating spermatogonia is not clear. This study explored the role and molecular mechanism of RNF187 in a mouse spermatogonia cell line (GC-1). We found that RNF187 knockdown reduced the proliferation and migration of GC-1 cells and promoted their apoptosis. RNF187 overexpression significantly increased the proliferation and migration of GC-1 cells. In addition, we identified Keratin36/Keratin84 (KRT36/KRT84) as interactors with RNF187 by co-immunoprecipitation and mass spectrometry analyses. RNF187 promoted GC-1 cell growth by degrading KRT36/KRT84 via lysine 48-linked polyubiquitination. Subsequently, we found that KRT36 or KRT84 overexpression significantly attenuated proliferation and migration of RNF187-overexpressing GC-1 cells. In summary, our study explored the involvement of RNF187 in regulating the growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84. This may provide a promising new strategy for treating infertility caused by abnormal spermatogonia development. - Source: PubMed
Yu XianglingXu BingyaGao TingtingFu XuJiang BingZhou NianchaoGao WenxinWu TiantianShen CongHuang XiaoyanWu YiboZheng Bo - Cashmere goats are a heterogeneous hairy mammal. The fineness of cashmere can affect its economic value. Therefore, in this study, we used transcriptome sequencing techniques to analyze the gene expression profiles of the skin tissues of cashmere goats with different cashmere fineness. The selected candidate genes were functionally verified with the secondary hair follicle hair papillary cells of cashmere goats. - Source: PubMed
Publication date: 2022/07/21
Wu CuilingLi JianyingXu XinmingXu QiQin ChongkaiLiu GuifenWei ChenZhang GuopingTian KechuanFu Xuefeng - Human keratin 36 (K36) is a member of the hair keratin family and is a marker of hair cortex differentiation. The human gene is located on the long arm of chromosome 17 and belongs to the cluster of structurally unrelated acidic hair keratins. Recently, it has been reported that mRNA is specifically expressed in normal tongue epithelium and downregulated in squamous cell carcinomas of the mobile tongue. Furthermore, levels have been reported to be downregulated in clinically normal mobile tongue tissue that is adjacent to tumours, suggesting it could be a marker of pre-neoplastic changes. However, the exact role and the potential role of K36 in tongue tumour formation remains unclear. The aim of the present study was to investigate expression of K36 in a series of squamous cell carcinomas of the mobile tongue, normal mobile tongue and a small panel of other human tissues (normal tissue from the appendix, cervix, hair, lip, mamilla, nail, oesophagus, skin, thymus and vagina) and selected cancer tissue (cervical cancer, melanoma and basal cell carcinoma). Affinity purified polyclonal antibodies against K36 were generated and used for immunohistochemical analysis. The results revealed that in the normal tongue, K36 was detected specifically in the filiform papillae of the dorsal surface of the tongue. Additionally, none of the tongue cancer tissue samples were K36-positive. Immunostaining also revealed that K36 was expressed in nail beds, Hassal's corpuscles in the thymus and the hair cortex. However, K36 was not expressed in the squamous epithelia of the skin, cervix and oesophagus, and the squamous cells of cervical carcinomas, basal cell carcinoma or melanoma. The present data indicated that K36 may be inactivated in tumours of the tongue. However, whether this is part of the tumoural process or if it is an effect of the tumour itself remains to be elucidated. - Source: PubMed
Publication date: 2020/02/26
Brychtova VeronikaCoates Philip JHrabal VaclavBoldrup LindaFabian PavelVojtesek BorivojSgaramella NicolaNylander Karin - The purpose of this study was to investigate the genetic effects of six keratin () genes on the wool traits of 418 Chinese Merino (Xinjiang type) (CMXT) individuals. - Source: PubMed
Publication date: 2017/11/03
Sulayman AblatTursun MahiraSulaiman YimingHuang XixiaTian KechuanTian YuezhenXu XinmingFu XuefengMamat AmatTulafu Hanikezi