Ask about this productRelated genes to: INSRR antibody
- Gene:
- INSRR NIH gene
- Name:
- insulin receptor related receptor
- Previous symbol:
- -
- Synonyms:
- IRR
- Chromosome:
- 1q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-05-18
- Date modifiied:
- 2016-10-05
Related products to: INSRR antibody
Related articles to: INSRR antibody
- The orphan insulin receptor-related receptor (IRR), in contrast to its homologs from the insulin receptor family, is activated by a mildly alkaline extracellular medium. We have previously demonstrated that IRR activation is defined by two synergistic sites located in the dimeric extracellular domain. Here, we describe artificial mutations in the IRR transmembrane domain that promote receptor activation. First, using molecular modeling based on the NMR-derived structure, we proposed amino acid substitutions that could enhance non-covalent interactions between the transmembrane segments of the IRR dimer. These mutations were subsequently tested for effects on pH sensing by IRR. We showed that double-mutant A938E-A939R was highly phosphorylated at neutral pH and still sensitive to alkaline pH. Remarkably, the double substitution of V929E-G930R resulted in strong basal phosphorylation of the receptor over the pH titration range. Through site-directed mutagenesis, we demonstrated that the transmembrane domain plays a critical role in IRR activation, allowing for targeted control of functioning of the receptor, including its pH sensitivity. - Source: PubMed
Publication date: 2026/05/14
Serova Oxana VGavrilenkova Alina AKuznetsov Andrey SGoryashchenko Alexander SAgisheva Alexandra RBershatsky Yaroslav VLushpa Vladislav AZangieva Olga TKarbyshev Mikhail SGerasimov Andrei SOkhrimenko Ivan SEfremov Roman GDeyev Igor EBocharov Eduard V - In terrestrial animals, the somatotropic axis, comprising growth hormone (GH) and insulin-like growth factors (IGFs), is pivotal in regulating growth and development. Marine mollusks play a vital role in the aquaculture industry, and understanding the molecular mechanisms of mollusk growth is of great value to breeding fast-growing and high-yielding varieties. Unlike terrestrial animals, marine mollusks lack a model species for laboratory breeding, leaving many growth-related genes unvalidated. The dwarf surf clam , with its small size, short breeding cycle, and ease of cultivation in laboratory settings, serves as an ideal model for investigating growth regulation. This study is the first systematic identification of genes related to growth, with 195 differentially expressed genes (DEGs) being found between fast- and slow-growing individuals through transcriptome comparison. KEGG analysis revealed significant enrichment of the insulin-like signaling pathway, and the insulin-like peptide () was the most significantly upregulated. As the insulin signaling pathway is activated by ligand-receptor binding, we further characterized and functionally validated and its receptor, the insulin receptor-related receptor (). RNA interference (RNAi)-mediated knockdown of or resulted in growth retardation, confirming their positive roles in growth regulation. Notably, silencing of these two genes caused significant upregulation of downstream genes, suggesting a compensatory mechanism for maintaining cell homeostasis. Our findings advance the understanding of growth regulation in mollusks and provide candidate genes for scallop breeding aiming at growth improvement. - Source: PubMed
Publication date: 2026/03/30
Kong LinglingKong XiangfuMeng DetingZhang XiangchaoMeng JieBao ZhenminHu Xiaoli - Type B insulin resistance (TBIR) is a rare autoimmune disorder characterized by insulin resistance (IR) secondary to insulin receptor autoantibodies (InsR-aAb). A paucity of clinical InsR-aAb assays and incomplete mechanistic understanding complicate diagnosis. - Source: PubMed
Lee Jennifer EChillon Thilo SMinich Waldemar BAbel Brent SLightbourne MarissaSchomburg LutzBrown Rebecca J - Insulin resistance (IR) is a risk factor for various diseases. Diet plays a crucial role in the development of IR. The high-protein diet (HPD) is gaining popularity for its weight control benefit. However, some types of protein can be metabolized by gut microbiota into trimethylamine (TMA), subsequently oxidized into trimethylamine N-oxide (TMAO) in the liver. However, the underlying mechanism of HPD-induced IR remains unclear. In this study, we firstly investigated whether the HPD can induce IR. Next, we examined liver function and the signaling pathways involved in IR. At last, we detected changes in the composition and function of gut microbiota, particularly concerning TMA production. Our results demonstrated that the HPD induces IR and liver injury, 41% higher TMA concentration than in the control group. Transcriptome results confirmed that insulin-related pathways were enriched in the HPD group, especially the gene, which regulates insulin action through its receptor, was downregulated. Disrupted gut microbiota, dominated by 65.0% of Firmicutes, which have high potential in TMA production. Moreover, several amino acid metabolism pathways closely linked to IR were enriched in the HPD group. These findings highlight the need for careful dietary management, as the HPD can induce IR and liver injury, with gut microbiota playing a key role in TMA production. - Source: PubMed
Publication date: 2025/06/07
Li YuhuiShao TiantianCao YatingZhang JigangWang AnqiShi YichenLiu Yehao - Easy to obtain and in close proximity to the affected areas, fecal samples offer significant potential for the advancement of non-invasive diagnostic methods for inflammatory bowel disease (IBD). A cross-sectional antibody array-based proteomic screen of 1000 fecal protein biomarkers was conducted using stool from treatment naïve control, Crohn's disease (CD), and ulcerative colitis (UC) subjects (control = 24, CD = 39, UC = 10). 71 proteins were significantly elevated in IBD stool (p < 0.05; FC > 2), pointing to cytokine signaling, inflammatory response and extra-cellular matrix functional pathways. Several proteins outperformed fecal calprotectin in distinguishing IBD from control stool, including Haptoglobin, IL-1 R9, GDF-15, PGRPS, Serpin A4, INSRR, SSEA-1, Fibrinogen, IGFBP-1, and TGF-β RI/ALK-5. Upon ELISA validation, PGRPS (AUC = 0.96), Haptoglobin (AUC = 0.91), Serpin A4 (AUC = 0.73), emerged as the most discriminatory biomarkers. Taken together with previous cross-sectional and longitudinal studies, the present findings authenticate stool PGRPS, Haptoglobin, Serpin A4 and fibrinogen as potential stool biomarkers of UC and CD, worthy of further prospective studies to identify more reliable and accurate non-invasive biomarkers for IBD. - Source: PubMed
Publication date: 2025/04/17
Pereira RyanSoomro SanamVanarsa KamalaCastillo JessicaMaruvada VinaikaKugathasan SubraMohan Chandra