Ask about this productRelated genes to: INSRR antibody
- Gene:
- INSRR NIH gene
- Name:
- insulin receptor related receptor
- Previous symbol:
- -
- Synonyms:
- IRR
- Chromosome:
- 1q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-05-18
- Date modifiied:
- 2016-10-05
Related products to: INSRR antibody
Related articles to: INSRR antibody
- The regulatory mechanism of calcification mediated by osteoblasts is ambiguous. Previously, we had found a unique cell-surface A7 antigen recognized by an osteoblast-specific monoclonal antibody, which is specifically expressed in osteoblasts in bone tissues and is involved in the regulation of calcification. This study aimed to identify the molecular entity of the A7 antigen, which is a possible regulator of calcification, expressed on the surface of osteoblasts. - Source: PubMed
Publication date: 2026/07/10
Hiura HidenobuKyumoto-Nakamura YukariBadawy TamerUehara NorihisaLiu YingMatsumoto MasakiKoba EmikoOda MizuhoKukita SusumuZhang JingqiGu JiongyanKukita AkikoTakahashi IchiroYamaza TakayoshiKukita Toshio - Insulin resistance (IR) is a significant risk factor for various diseases, particularly during pregnancy. Dietary patterns have been reported to influence IR susceptibility. High-protein (HP) diet has gained popularity for its role in weight management. However, whether trimethylamine N-oxide (TMAO), which is produced in the liver from gut microbiota-derived metabolites of dietary protein, influences IR remains uncertain. In this study, we established a pregnant mouse model to examine the effect of an HP diet on IR, assess its impact on liver function, and investigate associated signaling pathways. The role of gut microbiota was also evaluated. We found that the HP diet induced liver injury in pregnant mice following significantly decreased body weight. The HP diet also elevated plasma TMAO levels and upregulated hepatic expression. Transcriptomic analysis revealed enrichment of insulin-related signaling pathways in the HP group, with notable downregulation of the gene. IR was induced through the IRS-1/PI3K/Akt signal pathway. Gut microbiota composition was disrupted in HP group, characterized by an increased Firmicutes/Bacteroidetes ratio and a higher abundance of the TMA-producing genus , indicating an elevated potential for TMA generation. Furthermore, several amino acid metabolism pathways closely linked to IR were also enriched in the HP group. In conclusion, our study demonstrates that HP diet induces liver injury and increases IR risk during pregnancy. Gut microbiota contributes to this process, in part through an enhanced capacity for TMA production. These findings highlight the need for greater attention to dietary patterns in pregnancy to mitigate metabolic risks. - Source: PubMed
Publication date: 2026/06/17
Chen XiaoqianMa KehaoShi YichenLi YuhuiJi YanliLiu Yehao - The orphan insulin receptor-related receptor (IRR), in contrast to its homologs from the insulin receptor family, is activated by a mildly alkaline extracellular medium. We have previously demonstrated that IRR activation is defined by two synergistic sites located in the dimeric extracellular domain. Here, we describe artificial mutations in the IRR transmembrane domain that promote receptor activation. First, using molecular modeling based on the NMR-derived structure, we proposed amino acid substitutions that could enhance non-covalent interactions between the transmembrane segments of the IRR dimer. These mutations were subsequently tested for effects on pH sensing by IRR. We showed that double-mutant A938E-A939R was highly phosphorylated at neutral pH and still sensitive to alkaline pH. Remarkably, the double substitution of V929E-G930R resulted in strong basal phosphorylation of the receptor over the pH titration range. Through site-directed mutagenesis, we demonstrated that the transmembrane domain plays a critical role in IRR activation, allowing for targeted control of functioning of the receptor, including its pH sensitivity. - Source: PubMed
Publication date: 2026/05/14
Serova Oxana VGavrilenkova Alina AKuznetsov Andrey SGoryashchenko Alexander SAgisheva Alexandra RBershatsky Yaroslav VLushpa Vladislav AZangieva Olga TKarbyshev Mikhail SGerasimov Andrei SOkhrimenko Ivan SEfremov Roman GDeyev Igor EBocharov Eduard V - In terrestrial animals, the somatotropic axis, comprising growth hormone (GH) and insulin-like growth factors (IGFs), is pivotal in regulating growth and development. Marine mollusks play a vital role in the aquaculture industry, and understanding the molecular mechanisms of mollusk growth is of great value to breeding fast-growing and high-yielding varieties. Unlike terrestrial animals, marine mollusks lack a model species for laboratory breeding, leaving many growth-related genes unvalidated. The dwarf surf clam , with its small size, short breeding cycle, and ease of cultivation in laboratory settings, serves as an ideal model for investigating growth regulation. This study is the first systematic identification of genes related to growth, with 195 differentially expressed genes (DEGs) being found between fast- and slow-growing individuals through transcriptome comparison. KEGG analysis revealed significant enrichment of the insulin-like signaling pathway, and the insulin-like peptide () was the most significantly upregulated. As the insulin signaling pathway is activated by ligand-receptor binding, we further characterized and functionally validated and its receptor, the insulin receptor-related receptor (). RNA interference (RNAi)-mediated knockdown of or resulted in growth retardation, confirming their positive roles in growth regulation. Notably, silencing of these two genes caused significant upregulation of downstream genes, suggesting a compensatory mechanism for maintaining cell homeostasis. Our findings advance the understanding of growth regulation in mollusks and provide candidate genes for scallop breeding aiming at growth improvement. - Source: PubMed
Publication date: 2026/03/30
Kong LinglingKong XiangfuMeng DetingZhang XiangchaoMeng JieBao ZhenminHu Xiaoli - Type B insulin resistance (TBIR) is a rare autoimmune disorder characterized by insulin resistance (IR) secondary to insulin receptor autoantibodies (InsR-aAb). A paucity of clinical InsR-aAb assays and incomplete mechanistic understanding complicate diagnosis. - Source: PubMed
Lee Jennifer EChillon Thilo SMinich Waldemar BAbel Brent SLightbourne MarissaSchomburg LutzBrown Rebecca J