Ask about this productRelated genes to: INSR antibody
- Gene:
- INSR NIH gene
- Name:
- insulin receptor
- Previous symbol:
- -
- Synonyms:
- CD220
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2017-07-07
Related products to: INSR antibody
Related articles to: INSR antibody
- Type 1 diabetes mellitus (T1DM) results from autoimmune-mediated destruction of pancreatic β-cells, leading to absolute insulin deficiency. Current treatments rely on insulin replacement and do not prevent β-cell loss. 4-Methylumbelliferone (4-MU), an inhibitor of hyaluronan synthesis, has shown anti-inflammatory and cytoprotective effects, but its therapeutic potential and mechanisms in T1DM remain unclear. - Source: PubMed
Publication date: 2026/06/29
Yang ShuoZhu ShanshanYu XinwenZhang WenchengWang XinJin YuxinWang WeitingZhao GuohongGao Bin - High-starch diets are increasingly used in aquafeeds to reduce feed costs, but carnivorous fish such as largemouth bass () have limited capacity to utilize dietary starch and are prone to hepatic metabolic disorders. In the present study, we evaluated whether dietary N-carbamylglutamate (NCG) could alleviate high-starch-induced hepatic oxidative stress and liver injury in largemouth bass. Fish were fed a control diet containing 11.50% starch, a high-starch diet containing 18.00% starch, or a high-starch diet supplemented with 0.15%, 0.20%, or 0.25% NCG for 8 weeks. Compared with the high-starch group, dietary NCG supplementation significantly reduced serum glucose and triglyceride levels, decreased hepatic glycogen and malondialdehyde contents, and increased hepatic superoxide dismutase and glutathione peroxidase activities. NCG also reduced serum alanine aminotransferase and aspartate aminotransferase activities and alleviated hepatic histopathological damage. At the transcriptional level, NCG upregulated genes related to insulin signaling, glycolysis, lipid catabolism, and antioxidant regulation, including , , , , , , , and , while downregulating the expression of , , , and multiple inflammation- and apoptosis-related genes. These changes were accompanied by increased serum nitric oxide levels and improved survival and growth performance under high-starch feeding conditions. Collectively, these results indicate that dietary NCG supplementation attenuates high-starch-induced hepatic oxidative stress and redox-associated liver injury in largemouth bass, which may be associated with the transcriptional modulation of genes related to the AMPK/Nrf2/Keap1 and mTOR/NF-κB signaling pathways. - Source: PubMed
Publication date: 2026/05/27
Cheng TaoChen JiandongLiu MengfeiTan BeipingChi Shuyan - Glucose and paracrine regulation of α-cells, particularly with respect to sex differences, is still poorly understood. Here, we imaged islets from GluCre:GCaMP6f mice in pancreatic slices, additionally loaded with a red Ca²⁺ indicator, to precisely interrogate Ca²⁺ dynamics in α-cells and the adjacent β- and δ-cells. During a glucose ramp (1.8-10.8 mM), α-cell Ca²⁺ oscillations were heterogeneous, antiphasic to β-cells, and inversely correlated with δ-cells. Selective inhibition of insulin receptor (InsR) and somatostatin receptor subtypes-2 and 3 (SSTR2/3) shifted the majority of α-cells to hyperactivity, delayed the decline of α-cell activity and onset of β-cell Ca²⁺ oscillations during the ramp. While female α-cells exhibited greater sensitivity to SSTR2/3 inhibition, male α-cells were more responsive to InsR blockade. Under complete SSTR2/3 and InsR antagonism, α-cells exhibited elevated Ca²⁺ oscillations but remained glucose-dependent. We conclude that intra-islet coordination fine-tunes α-cell glucose responses, with sex-specific paracrine signaling potentially shaping glucagon profiles in metabolic disease. - Source: PubMed
Publication date: 2026/06/23
Huang Ya-ChiSlak Rupnik MarjanRutter Guy A - High-latitude populations represent valuable case studies to investigate the genetic bases of human biological adaptations to cold climates. Nevertheless, by relying on traditional natural selection models, a limited fraction of them was identified. To overcome this issue, we integrate diverse inferential methods in the attempt to pinpoint combinations of genes presenting both selection signatures and functional relationships supporting their synergic role in regulating a biological trait, as expected under polygenic adaptation. We analyze Yakut genomes from Northeastern Siberia and Russian ones, pointing to adaptive evolution at genes contributing to functions modulated during cold exposure, such as thyroid hormone/insulin signalling (THRB, RCAN2, INSR, NFKB1), brown adipose tissue differentiation (ERBB4) and glycerolipid metabolism (GPAT3). Concerted changes at these loci may support enhanced heat production and responsiveness to insulin, having been partly influenced also by Neanderthal introgression, and provide suggestive insights into the complex adaptations that enabled Eurasians' ancestors to colonize cold environments. - Source: PubMed
Publication date: 2026/06/23
Ferraretti GiuliaAlberti MartaCicolini RositaPognant Viù SabrinaSarno StefaniaSazzini Marco - To explore the potential benefits and risks of glucose-lowering drugs on cardiovascular-kidney-metabolic (CKM) syndrome outcomes using drug-target Mendelian randomization (MR). - Source: PubMed
Publication date: 2026/05/11
Lu JianSun ShuaigangShang XinruJiang ShiminDeng ZekaiWang ShunweiWei ChenpingHu JiaqiLi Wenge