Ask about this productRelated genes to: INHBB antibody
- Gene:
- INHBB NIH gene
- Name:
- inhibin subunit beta B
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q14.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2018-04-23
Related products to: INHBB antibody
Related articles to: INHBB antibody
- Osteoarthritis (OA) is a complex degenerative joint disease for which early diagnosis and clear molecular characterization remain limited. DNA methylation has been increasingly recognized as an important regulatory factor in OA pathogenesis. In this study, we proposed an integrative computational framework combining statistical analysis, machine learning, deep learning, and functional genomics to identify and validate OA-associated genes and methylation biomarkers for diagnostic and biological interpretation. Candidate CpG sites were obtained using two complementary strategies: differential methylation analysis and selection of loci located near transcription start sites of previously reported OA-related genes. Key features were further refined using support vector machine recursive feature elimination and random forest algorithms. Based on the selected loci, we developed a feature-fusion diagnostic model that combines Transformer and convolutional neural networks with adaptive weighting to capture both global dependency structures and local methylation patterns. A panel of 220 methylation sites demonstrated stable and reproducible diagnostic performance in an independent cohort. Functional annotation and pathway analysis highlighted several established OA-associated genes, including , , , and , and suggested as a potential novel effector gene, with additional support for and involvement. Overall, this study presents a robust methylation-based framework for identifying key OA-associated genes and provides new insights into the epigenetic mechanisms underlying OA. - Source: PubMed
Publication date: 2026/04/09
Zhao JianWu ChangwuKuang ZhejunWang HanShi Lijuan - Colorectal cancer (CRC) represents a prevalent global malignancy, with its progression intimately associated with biological processes such as oxidative stress and anoikis. This study aimed to evaluate a prognostic model derived from oxidative stress and anoikis-related genes (OARGs) in CRC and to elucidate the underlying mechanisms of the core gene, INHBB. - Source: PubMed
Publication date: 2026/04/16
Chen HuiyanWu YaoHuang ZongxuanLuo DiWang ZimingWu JunhongZhou TianyuanZhao Hu - (CT) infection is one of the most prevalent sexually transmitted infections (STIs) worldwide and has been consistently associated with adverse reproductive outcomes, including female infertility. However, the molecular mechanisms underlying this association remain incompletely understood. This study aimed to investigate whether genes previously associated with female infertility display altered expression patterns in response to CT infection by reanalyzing publicly available transcriptomic data derived from a human in vitro infection model. : An integrative in silico approach was employed. A curated list of 106 genes associated with female infertility was compiled from publicly available databases and integrated with transcriptomic data from the Gene Expression Omnibus (GEO) dataset GSE109428, which profiles primary human fallopian tube mesenchymal cells infected in vitro with CT serovar L2. Gene expression changes were evaluated at two time points (24 and 48 h post-infection) by comparing infected cells with uninfected control samples, followed by functional and phenotype enrichment analyses. : One female infertility-associated gene () was consistently dysregulated at both 24 and 48 h post-infection. In addition, fourteen genes (, , , , , , , , , , , , , and ) became significantly dysregulated exclusively at 48 h post-infection, indicating a time-dependent host transcriptional response to CT infection. Functional and phenotype enrichment analyses revealed associations with biological processes related to embryonic development and meiosis, as well as phenotypes linked to female infertility. These enriched terms were supported by a small subset of genes and were therefore interpreted cautiously. Overall, these findings suggest that CT infection modulates the expression of several infertility-associated genes and may influence biological pathways critical for female reproductive function. While exploratory, this study provides a molecular context that aligns with previously reported associations between CT infection and female infertility. - Source: PubMed
Publication date: 2026/03/01
Rodrigues RafaelaSousa CarlosVale Nuno - Spinal cord injury is a leading cause of neurogenic bladder and upper urinary tract deterioration, yet the molecular remodeling of epithelial-stromal signaling axes in this context remains incompletely defined. The activin-follistatin-inhibin axis, a branch of the transforming growth factor-β superfamily, has been implicated in tissue repair, inflammation, and fibrosis, but its behavior in the lower urinary tract after SCI is unknown. - Source: PubMed
Publication date: 2026/02/18
Shen YuchengYang ShengkaiZhou HaiZhu YongkunWang ZhongJiang Weimin - Focused ultrasound, low-intensity focused ultrasound, and microbubble-enhanced sonoporation are examples of ultrasound-based cancer therapies that have shown promise as biophysical modalities for enhancing drug penetration, immunogenic cell death, and targeted delivery of radiopharmaceuticals in solid tumors. The molecular factors controlling ultrasonic therapy receptivity, however, are still not well understood. Because of the significant variability of the tumor microenvironment (TME), colorectal cancer (CRC) necessitates biomarker-guided techniques to enhance ultrasound-based therapy regimens. - Source: PubMed
Publication date: 2026/02/25
Zhang XiaohuiCao XuguangSu XinyaoHu WeiHou ShuoshuoZhou XiaohuaYang HongbaoJi Hongjian